Scaffold hopping. Böhm, H., Flohr, A., & Stahl, M. Drug Discov.~Today Technol., 1(3):217--224, Dec, 2004. doi abstract bibtex The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core structures, and yet binding to the same receptor. Computational approaches for scaffold hopping highlight the challenges of the field that are still unsolved.:
@article{Bohm:2004rv,
Abstract = {The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core structures, and yet binding to the same receptor. Computational approaches for scaffold hopping highlight the challenges of the field that are still unsolved.:},
Author = {B\"{o}hm, Hans-Joachim and Flohr, Alexander and Stahl, Martin},
Date-Added = {2014-09-27 02:28:25 +0000},
Date-Modified = {2014-09-27 02:32:16 +0000},
Doi = {10.1016/j.ddtec.2004.10.009},
Journal = {Drug Discov.~Today Technol.},
Journal-Full = {Drug discovery today. Technologies},
Month = {Dec},
Number = {3},
Pages = {217--224},
Pmid = {24981488},
Pst = {ppublish},
Title = {Scaffold hopping},
Volume = {1},
Year = {2004},
Bdsk-Url-1 = {http://dx.doi.org/10.1016/j.ddtec.2004.10.009}}
Downloads: 0
{"_id":"oSDg4R5KAyK6N5jc3","bibbaseid":"bhm-flohr-stahl-scaffoldhopping-2004","downloads":0,"creationDate":"2016-02-18T13:03:28.356Z","title":"Scaffold hopping","author_short":["Böhm, H.","Flohr, A.","Stahl, M."],"year":2004,"bibtype":"article","biburl":"https://dl.dropboxusercontent.com/u/26998770/main.bib","bibdata":{"bibtype":"article","type":"article","abstract":"The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core structures, and yet binding to the same receptor. Computational approaches for scaffold hopping highlight the challenges of the field that are still unsolved.:","author":[{"propositions":[],"lastnames":["Böhm"],"firstnames":["Hans-Joachim"],"suffixes":[]},{"propositions":[],"lastnames":["Flohr"],"firstnames":["Alexander"],"suffixes":[]},{"propositions":[],"lastnames":["Stahl"],"firstnames":["Martin"],"suffixes":[]}],"date-added":"2014-09-27 02:28:25 +0000","date-modified":"2014-09-27 02:32:16 +0000","doi":"10.1016/j.ddtec.2004.10.009","journal":"Drug Discov.~Today Technol.","journal-full":"Drug discovery today. Technologies","month":"Dec","number":"3","pages":"217--224","pmid":"24981488","pst":"ppublish","title":"Scaffold hopping","volume":"1","year":"2004","bdsk-url-1":"http://dx.doi.org/10.1016/j.ddtec.2004.10.009","bibtex":"@article{Bohm:2004rv,\n\tAbstract = {The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core structures, and yet binding to the same receptor. Computational approaches for scaffold hopping highlight the challenges of the field that are still unsolved.:},\n\tAuthor = {B\\\"{o}hm, Hans-Joachim and Flohr, Alexander and Stahl, Martin},\n\tDate-Added = {2014-09-27 02:28:25 +0000},\n\tDate-Modified = {2014-09-27 02:32:16 +0000},\n\tDoi = {10.1016/j.ddtec.2004.10.009},\n\tJournal = {Drug Discov.~Today Technol.},\n\tJournal-Full = {Drug discovery today. Technologies},\n\tMonth = {Dec},\n\tNumber = {3},\n\tPages = {217--224},\n\tPmid = {24981488},\n\tPst = {ppublish},\n\tTitle = {Scaffold hopping},\n\tVolume = {1},\n\tYear = {2004},\n\tBdsk-Url-1 = {http://dx.doi.org/10.1016/j.ddtec.2004.10.009}}\n\n","author_short":["Böhm, H.","Flohr, A.","Stahl, M."],"key":"Bohm:2004rv","id":"Bohm:2004rv","bibbaseid":"bhm-flohr-stahl-scaffoldhopping-2004","role":"author","urls":{},"downloads":0},"search_terms":["scaffold","hopping","böhm","flohr","stahl"],"keywords":[],"authorIDs":[],"dataSources":["c5japf9eAQRaeMS4h"]}