Simultaneous analysis of historical, emerging and novel brominated flame retardants in food and feed using a common extraction and purification method

Simultaneous analysis of historical, emerging and novel brominated flame retardants in food and feed using a common extraction and purification method. Bichon, E., Guiffard, I., Vénisseau, A., Lesquin, E., Vaccher, V., Marchand, P., & Le Bizec, B. 205:31–40.

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Brominated Flame Retardants (BFRs) are still widely used for industrial purposes. These contaminants may enter the food chain where they mainly occur in food of animal origin. The aim of our work was to provide a unique method able to quantify the widest range of BFRs in feed and food items. After freezedrying and grinding, a pressurized liquid extraction was carried out. The extract was puriﬁed on acidiﬁed silica, Florisil® and carbon columns, the four separated fractions were analyzed by gas and liquid chromatography coupled to high resolution and tandem mass spectrometry. Isotopic dilution was preferentially used when commercial labelled compounds were available. Analytical sensitivity was in accordance with the expectations of Recommendation 2014/118/EU for PBDEs, HBCDDs, TBBPA, TBBPAbME, EHTBB, BEHTEBP and TBBPA-bME. Additional BFRs were included in this analytical method with the same level of performances (LOQs below 0.01 ng gÀ1 ww). These are PBBs, pTBX, TBCT, PBBz, PBT, PBEB, HBBz, BTBPE, OBIND and T23BPIC. However, some of the BFRs listed in Recommendation 2014/118/ EU are not yet covered by our analytical method, i.e. TBBPA-bOHEE, TBBPA-bAE, TBBPA-bGE, TBBPAbDiBPrE, TBBPS, TBBPS-bME, TDBPP, EBTEBPI, HBCYD and DBNPG. The uncertainty measurement was fully calculated for 21 of the 31 analytes monitored in the method. Reproducibility uncertainty was below 23% in isotopic dilution. Certiﬁed reference materials are now required to better characterize the trueness of this method, which was applied in the French National Control Plans.

@article{bichon_simultaneous_2018,
	title = {Simultaneous analysis of historical, emerging and novel brominated flame retardants in food and feed using a common extraction and purification method},
	volume = {205},
	issn = {00456535},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0045653518307185},
	doi = {10.1016/j.chemosphere.2018.04.070},
	abstract = {Brominated Flame Retardants ({BFRs}) are still widely used for industrial purposes. These contaminants may enter the food chain where they mainly occur in food of animal origin. The aim of our work was to provide a unique method able to quantify the widest range of {BFRs} in feed and food items. After freezedrying and grinding, a pressurized liquid extraction was carried out. The extract was puriﬁed on acidiﬁed silica, Florisil® and carbon columns, the four separated fractions were analyzed by gas and liquid chromatography coupled to high resolution and tandem mass spectrometry. Isotopic dilution was preferentially used when commercial labelled compounds were available. Analytical sensitivity was in accordance with the expectations of Recommendation 2014/118/{EU} for {PBDEs}, {HBCDDs}, {TBBPA}, {TBBPAbME}, {EHTBB}, {BEHTEBP} and {TBBPA}-{bME}. Additional {BFRs} were included in this analytical method with the same level of performances ({LOQs} below 0.01 ng {gÀ}1 ww). These are {PBBs}, {pTBX}, {TBCT}, {PBBz}, {PBT}, {PBEB}, {HBBz}, {BTBPE}, {OBIND} and T23BPIC. However, some of the {BFRs} listed in Recommendation 2014/118/ {EU} are not yet covered by our analytical method, i.e. {TBBPA}-{bOHEE}, {TBBPA}-{bAE}, {TBBPA}-{bGE}, {TBBPAbDiBPrE}, {TBBPS}, {TBBPS}-{bME}, {TDBPP}, {EBTEBPI}, {HBCYD} and {DBNPG}. The uncertainty measurement was fully calculated for 21 of the 31 analytes monitored in the method. Reproducibility uncertainty was below 23\% in isotopic dilution. Certiﬁed reference materials are now required to better characterize the trueness of this method, which was applied in the French National Control Plans.},
	pages = {31--40},
	journaltitle = {Chemosphere},
	author = {Bichon, Emmanuelle and Guiffard, Ingrid and Vénisseau, Anaïs and Lesquin, Elodie and Vaccher, Vincent and Marchand, Philippe and Le Bizec, Bruno},
	urldate = {2019-03-29},
	date = {2018-08},
	langid = {english},
	file = {Bichon et al. - 2018 - Simultaneous analysis of historical, emerging and .pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\SBZ3WJE5\\Bichon et al. - 2018 - Simultaneous analysis of historical, emerging and .pdf:application/pdf}
}

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