@article{Bick-2012-ID10,
  title     = {Evolutionary diversity of the mitochondrial calcium uniporter.},
  abstract  = {Calcium uptake into mitochondria occurs via a recently identified ion
               channel called the uniporter. Here, we characterize the phylogenomic
               distribution of the uniporter's membrane-spanning pore subunit ({MCU}) and
               regulatory partner ({MICU}1). Homologs of both components tend to co-occur
               in all major branches of eukaryotic life, but both have been lost along
               certain protozoan and fungal lineages. Several bacterial genomes also
               contain putative {MCU} homologs that may represent prokaryotic calcium
               channels. The analyses indicate that the uniporter may have been an early
               feature of mitochondria.},
  author    = {Bick, Alexander G and Calvo, Sarah E and Mootha, Vamsi K},
  volume    = {336},
  number    = {6083},
  pages     = {886},
  year      = {2012},
  month     = {5},
  url       = {http://www.pubmed.org/22605770},
  pmcid     = {3518847},
  pmid      = {22605770},
  doi       = {10.1126/science.1214977},
  keywords  = {Animals, Humans, Mitochondria, Bacteria, Bacterial Proteins, Calcium
               Channels, Calcium-Binding Proteins, Cation Transport Proteins, Eukaryota,
               Evolution, Molecular, Genome, Mitochondrial Membrane Transport Proteins,
               Phylogeny, Protein Structure, Tertiary, Proteome},
  file      = {FULLTEXT:pdfs/000/000/000000010.pdf:PDF}
}

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