Effects of rising carbon dioxide levels on human health via breathing toxicity-A critical issue that remains unapprehended. Bierwirth, P. N. 2015.
Effects of rising carbon dioxide levels on human health via breathing toxicity-A critical issue that remains unapprehended [pdf]Paper  abstract   bibtex   
As atmospheric levels of carbon dioxide continue to escalate as a driver of climate change, the issue of CO2 toxicity is not recognised as a global risk by the science community. The toxicity of CO2 for breathing has been well defined for high concentrations but it remains effectively unknown what level will compromise human health when individuals are exposed for their whole life. There is evidence from the few studies of long-term low-level exposure that permanent exposure, to CO2 levels predicted by the end of the century, will have significant effects on humans. Other studies of slightly higher CO2 levels may offer clues to effects, not yet observed, that may occur when humans experience lifelong exposure. Although humans and animals are able to deal with elevated levels of CO2 in the short-term due to various compensation mechanisms in the body, the persistent effects of these mechanisms may have severe consequences in a perpetual environment of elevated CO2. These include threats to life such as kidney failure, bone atrophy and loss of brain function. Existing research also indicates that as ambient CO2 increases in the near-future, there will be an associated increase in cancers, neurological disorders and many other conditions. Research is urgently required to clearly identify the severity and proximity of this risk, associated with the primary human function of breathing, being a potential major aspect of climate change.

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