Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury. Biesbroek, J. M., Leemans, A., den Bakker, H., Duering, M., Gesierich, B., Koek, H. L., van den Berg, E., Postma, A., & Biessels, G. J. Dement Geriatr Cogn Disord, 44(5-6):268–282, 2017. doi abstract bibtex BACKGROUND: White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS: We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. RESULTS: On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4% (p = 0.014), 7.8% (p \textless 0.001), and 1.2% (p = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4% (p = 0.012), 3.8% (p = 0.007), and 2.1% (p = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. CONCLUSION: In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.
@article{biesbroek_microstructure_2017,
title = {Microstructure of {Strategic} {White} {Matter} {Tracts} and {Cognition} in {Memory} {Clinic} {Patients} with {Vascular} {Brain} {Injury}},
volume = {44},
issn = {1421-9824 (Electronic) 1420-8008 (Linking)},
doi = {10.1159/000485376},
abstract = {BACKGROUND: White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS: We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. RESULTS: On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4\% (p = 0.014), 7.8\% (p {\textless} 0.001), and 1.2\% (p = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4\% (p = 0.012), 3.8\% (p = 0.007), and 2.1\% (p = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. CONCLUSION: In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.},
number = {5-6},
journal = {Dement Geriatr Cogn Disord},
author = {Biesbroek, J. M. and Leemans, A. and den Bakker, H. and Duering, M. and Gesierich, B. and Koek, H. L. and van den Berg, E. and Postma, A. and Biessels, G. J.},
year = {2017},
pmcid = {PMC5972515},
pmid = {29353280},
keywords = {Cognition, Small vessel disease, Aged, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Aged, 80 and over, Magnetic Resonance Imaging, *Diffusion tensor imaging, *Small vessel disease, White Matter/*diagnostic imaging, Cohort Studies, Executive Function, Neuropsychological Tests, Atrophy, Diffusion tensor imaging, *Alzheimer disease, *Cognition, *Strategic white matter tract, *Vascular dementia, Anisotropy, Cerebral Infarction/diagnostic imaging, Cerebrovascular Disorders/*diagnostic imaging/*psychology, Cognition Disorders/diagnostic imaging/psychology, Memory Disorders/*diagnostic imaging/*psychology, Psychomotor Performance, White Matter, Cerebral Infarction, Cognition Disorders, Cerebrovascular Disorders, Vascular dementia, Alzheimer disease, Memory Disorders, Strategic white matter tract},
pages = {268--282},
}
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METHODS: We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. RESULTS: On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4% (p = 0.014), 7.8% (p \\textless 0.001), and 1.2% (p = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4% (p = 0.012), 3.8% (p = 0.007), and 2.1% (p = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. CONCLUSION: In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.","number":"5-6","journal":"Dement Geriatr Cogn Disord","author":[{"propositions":[],"lastnames":["Biesbroek"],"firstnames":["J.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Leemans"],"firstnames":["A."],"suffixes":[]},{"propositions":["den"],"lastnames":["Bakker"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Duering"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Gesierich"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Koek"],"firstnames":["H.","L."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Berg"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Biessels"],"firstnames":["G.","J."],"suffixes":[]}],"year":"2017","pmcid":"PMC5972515","pmid":"29353280","keywords":"Cognition, Small vessel disease, Aged, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Aged, 80 and over, Magnetic Resonance Imaging, *Diffusion tensor imaging, *Small vessel disease, White Matter/*diagnostic imaging, Cohort Studies, Executive Function, Neuropsychological Tests, Atrophy, Diffusion tensor imaging, *Alzheimer disease, *Cognition, *Strategic white matter tract, *Vascular dementia, Anisotropy, Cerebral Infarction/diagnostic imaging, Cerebrovascular Disorders/*diagnostic imaging/*psychology, Cognition Disorders/diagnostic imaging/psychology, Memory Disorders/*diagnostic imaging/*psychology, Psychomotor Performance, White Matter, Cerebral Infarction, Cognition Disorders, Cerebrovascular Disorders, Vascular dementia, Alzheimer disease, Memory Disorders, Strategic white matter tract","pages":"268–282","bibtex":"@article{biesbroek_microstructure_2017,\n\ttitle = {Microstructure of {Strategic} {White} {Matter} {Tracts} and {Cognition} in {Memory} {Clinic} {Patients} with {Vascular} {Brain} {Injury}},\n\tvolume = {44},\n\tissn = {1421-9824 (Electronic) 1420-8008 (Linking)},\n\tdoi = {10.1159/000485376},\n\tabstract = {BACKGROUND: White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS: We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis. RESULTS: On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4\\% (p = 0.014), 7.8\\% (p {\\textless} 0.001), and 1.2\\% (p = 0.119) variance in executive functioning, speed, and memory, respectively. The Bayesian analyses of regional DTI measures identified strategic tracts for executive functioning (right superior longitudinal fasciculus), speed (left corticospinal tract), and memory (left uncinate fasciculus). MD within these tracts explained an additional 3.4\\% (p = 0.012), 3.8\\% (p = 0.007), and 2.1\\% (p = 0.041) variance in executive functioning, speed, and memory, respectively, on top of all conventional MRI and global DTI markers combined. CONCLUSION: In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.},\n\tnumber = {5-6},\n\tjournal = {Dement Geriatr Cogn Disord},\n\tauthor = {Biesbroek, J. M. and Leemans, A. and den Bakker, H. and Duering, M. and Gesierich, B. and Koek, H. L. and van den Berg, E. and Postma, A. and Biessels, G. 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