An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2. Biffi, G., Tannahill, D., & Balasubramanian, S. Journal of the American Chemical Society, 134(29):11974–6, July, 2012. ![An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Telomeric repeat-containing RNA (TERRA) is important for telomere regulation, but the structural basis for how TERRA localizes to chromosome ends is unknown. Here we report on studies exploring whether the TERRA G-quadruplex structure is critical for binding to telomeres. We demonstrate that the telomeric protein TRF2 binds TERRA via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. We also show that TRF2 simultaneously binds TERRA and telomeric duplex or G-quadruplex DNA. These observations suggest that the TERRA G-quadruplex is a key feature of telomere organization.
@article{Biffi2012,
title = {An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing {RNA} to the telomeric protein {TRF2}.},
volume = {134},
issn = {1520-5126},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22780456},
doi = {10.1021/ja305734x},
abstract = {Telomeric repeat-containing RNA (TERRA) is important for telomere regulation, but the structural basis for how TERRA localizes to chromosome ends is unknown. Here we report on studies exploring whether the TERRA G-quadruplex structure is critical for binding to telomeres. We demonstrate that the telomeric protein TRF2 binds TERRA via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. We also show that TRF2 simultaneously binds TERRA and telomeric duplex or G-quadruplex DNA. These observations suggest that the TERRA G-quadruplex is a key feature of telomere organization.},
number = {29},
journal = {Journal of the American Chemical Society},
author = {Biffi, Giulia and Tannahill, David and Balasubramanian, Shankar},
month = jul,
year = {2012},
pmid = {22780456},
keywords = {\#nosource},
pages = {11974--6},
}
Downloads: 0
{"_id":"a3QYbMZdfThA6Zh7y","bibbaseid":"biffi-tannahill-balasubramanian-anintramoleculargquadruplexstructureisrequiredforbindingoftelomericrepeatcontainingrnatothetelomericproteintrf2-2012","author_short":["Biffi, G.","Tannahill, D.","Balasubramanian, S."],"bibdata":{"bibtype":"article","type":"article","title":"An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.","volume":"134","issn":"1520-5126","url":"http://www.ncbi.nlm.nih.gov/pubmed/22780456","doi":"10.1021/ja305734x","abstract":"Telomeric repeat-containing RNA (TERRA) is important for telomere regulation, but the structural basis for how TERRA localizes to chromosome ends is unknown. Here we report on studies exploring whether the TERRA G-quadruplex structure is critical for binding to telomeres. We demonstrate that the telomeric protein TRF2 binds TERRA via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. We also show that TRF2 simultaneously binds TERRA and telomeric duplex or G-quadruplex DNA. These observations suggest that the TERRA G-quadruplex is a key feature of telomere organization.","number":"29","journal":"Journal of the American Chemical Society","author":[{"propositions":[],"lastnames":["Biffi"],"firstnames":["Giulia"],"suffixes":[]},{"propositions":[],"lastnames":["Tannahill"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Balasubramanian"],"firstnames":["Shankar"],"suffixes":[]}],"month":"July","year":"2012","pmid":"22780456","keywords":"#nosource","pages":"11974–6","bibtex":"@article{Biffi2012,\n\ttitle = {An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing {RNA} to the telomeric protein {TRF2}.},\n\tvolume = {134},\n\tissn = {1520-5126},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/22780456},\n\tdoi = {10.1021/ja305734x},\n\tabstract = {Telomeric repeat-containing RNA (TERRA) is important for telomere regulation, but the structural basis for how TERRA localizes to chromosome ends is unknown. Here we report on studies exploring whether the TERRA G-quadruplex structure is critical for binding to telomeres. We demonstrate that the telomeric protein TRF2 binds TERRA via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. We also show that TRF2 simultaneously binds TERRA and telomeric duplex or G-quadruplex DNA. These observations suggest that the TERRA G-quadruplex is a key feature of telomere organization.},\n\tnumber = {29},\n\tjournal = {Journal of the American Chemical Society},\n\tauthor = {Biffi, Giulia and Tannahill, David and Balasubramanian, Shankar},\n\tmonth = jul,\n\tyear = {2012},\n\tpmid = {22780456},\n\tkeywords = {\\#nosource},\n\tpages = {11974--6},\n}\n\n","author_short":["Biffi, G.","Tannahill, D.","Balasubramanian, S."],"key":"Biffi2012","id":"Biffi2012","bibbaseid":"biffi-tannahill-balasubramanian-anintramoleculargquadruplexstructureisrequiredforbindingoftelomericrepeatcontainingrnatothetelomericproteintrf2-2012","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/22780456"},"keyword":["#nosource"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource"],"search_terms":["intramolecular","quadruplex","structure","required","binding","telomeric","repeat","containing","rna","telomeric","protein","trf2","biffi","tannahill","balasubramanian"],"title":"An intramolecular g-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.","year":2012}