GeneWise and Genomewise

GeneWise and Genomewise. Birney, E., Clamp, M., & Durbin, R. Genome Research, 14(5):988–995, May, 2004.

We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.

@article{birney_genewise_2004,
	title = {{GeneWise} and {Genomewise}},
	volume = {14},
	issn = {1088-9051},
	url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479130/},
	doi = {10.1101/gr.1865504},
	abstract = {We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.},
	number = {5},
	urldate = {2022-04-06},
	journal = {Genome Research},
	author = {Birney, Ewan and Clamp, Michele and Durbin, Richard},
	month = may,
	year = {2004},
	pmid = {15123596},
	pmcid = {PMC479130},
	pages = {988--995},
	file = {Texte intégral:C\:\\Users\\qcarrade\\Zotero\\storage\\JGBNM93F\\Birney et al. - 2004 - GeneWise and Genomewise.pdf:application/pdf},
}

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