Neuropeptide Y and bombesin in the cardiovascular system of fish. Bjenning, C. A. Ph.D. Thesis, Goteborgs Universitet (Sweden), Sweden, 1992.
Neuropeptide Y and bombesin in the cardiovascular system of fish [link]Paper  abstract   bibtex   
Background. Fish first evolved during the Ordovician period, more than 450 millions of years before mammals, and their control systems may represent the foundation for the design of control systems in all vertebrates. Thus, through studies of the fish nervous system, we may achieve valuable knowledge about basal neuropeptide functions in all the vertebrates. Aim. The studies focus on the nature and the distribution of neuropeptide Y (NPY) and bombesin (BM) in the cardiovascular system of fish, on the effects of NPY and BM on isolated parts from the elasmobranch cardiovascular system and on the mechanisms behind their actions. Methods. Immunohistochemistry, radioimmunoassay, HPLC and sequence analysis were used to study distribution, density, chemical properties and sequence of peptides. The functions of the peptides in the cardiovascular system were studied in a small vessel myograph, in organ baths and by perfusion of vascular beds. Results and conclusions. Peptides with a high structural similarity to porcine NPY are present in elasmobranch, holostean and teleost fish. The distribution of NPY varies between different species and tissues, for example: NPY-like immunoreactivity are present in the elasmobranch but not in the teleost cardiovascular system. Fish NPY-receptors recognize and respond to NPY-related peptides from other vertebrate species. NPY has a direct vasoconstrictor effect in the common dogfish (Scyliorhinus canicula) afferent gill artery, while NPY potentiates the effect of noradrenaline to constrict the longnose skate (Raja rhina) coronary artery. Bombesin-like peptides are present in more than one form in elasmobranch fish, and their distribution may be related to cardiovascular effects of bombesin. Bombesin has a direct vasodilator effect in the vascularly perfused spiny dogfish (Squalus acanthias) stomach, while the vasoconstrictor effect of bombesin in the longnose skate coronary artery is partly of indirect nature.
@phdthesis{bjenning_neuropeptide_1992,
	address = {Sweden},
	type = {Ph.{D}. {Thesis}},
	title = {Neuropeptide {Y} and bombesin in the cardiovascular system of fish},
	copyright = {Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.},
	url = {http://search.proquest.com.ezproxy.library.ubc.ca/pqdtglobal/docview/304007248/abstract/7DA72442FFF14BFDPQ/1},
	abstract = {Background. Fish first evolved during the Ordovician period, more than 450 millions of years before mammals, and their control systems may represent the foundation for the design of control systems in all vertebrates. Thus, through studies of the fish nervous system, we may achieve valuable knowledge about basal neuropeptide functions in all the vertebrates.
Aim. The studies focus on the nature and the distribution of neuropeptide Y (NPY) and bombesin (BM) in the cardiovascular system of fish, on the effects of NPY and BM on isolated parts from the elasmobranch cardiovascular system and on the mechanisms behind their actions.
Methods. Immunohistochemistry, radioimmunoassay, HPLC and sequence analysis were used to study distribution, density, chemical properties and sequence of peptides. The functions of the peptides in the cardiovascular system were studied in a small vessel myograph, in organ baths and by perfusion of vascular beds.
Results and conclusions. Peptides with a high structural similarity to porcine NPY are present in elasmobranch, holostean and teleost fish. The distribution of NPY varies between different species and tissues, for example: NPY-like immunoreactivity are present in the elasmobranch but not in the teleost cardiovascular system. Fish NPY-receptors recognize and respond to NPY-related peptides from other vertebrate species. NPY has a direct vasoconstrictor effect in the common dogfish (Scyliorhinus canicula) afferent gill artery, while NPY potentiates the effect of noradrenaline to constrict the longnose skate (Raja rhina) coronary artery.
Bombesin-like peptides are present in more than one form in elasmobranch fish, and their distribution may be related to cardiovascular effects of bombesin. Bombesin has a direct vasodilator effect in the vascularly perfused spiny dogfish (Squalus acanthias) stomach, while the vasoconstrictor effect of bombesin in the longnose skate coronary artery is partly of indirect nature.},
	language = {English},
	urldate = {2016-06-08},
	school = {Goteborgs Universitet (Sweden)},
	author = {Bjenning, Christina Anna},
	year = {1992},
	keywords = {Raja rhina, Scyliorhinus canicula},
}
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