Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Bjune, G., Høiby, E. A., Grønnesby, J. K., Arnesen, O., Fredriksen, J. H., Halstensen, A., Holten, E., Lindbak, A. K., Nøkleby, H., & Rosenqvist, E. Lancet, 338(8775):1093–1096, November, 1991. abstract bibtex For more than 15 years, Norway has had the highest incidence of meningococcal disease in northern Europe, with 80% of cases being due to serogroup B meningococci. The case-fatality has remained high, at about 10%. In this study, an outer membrane vaccine, which had previously been shown to induce an increase in bactericidal antibodies to the parent strain, was assessed in a large-scale, randomised, double-blind trial. From October, 1988, 171,800 students in secondary schools volunteered to take part in a double-blind, placebo-controlled, efficacy trial with school as the randomisation unit. Hospitals and clinics that routinely receive patients with infectious disease were asked to report urgently all cases of suspected meningitis and/or septicaemia in 13-21-year-old students in Norway. These cases were registered and further investigated according to a detailed protocol. 89 out of the 221 cases investigated by June 3, 1991, were shown to be severe systemic disease due to group B meningococci. 36 cases in 35 schools took part in the trial (11 schools with vaccinated students and 24 with students given placebo). The calculated rate of protection was thus 57.2% (p = 0.012, one-sided test). The findings suggest that, although the vaccine conferred protection against group B meningococcal disease, the effect was insufficient to justify a public vaccination programme.
@article{bjune_effect_1991,
title = {Effect of outer membrane vesicle vaccine against group {B} meningococcal disease in {Norway}},
volume = {338},
issn = {0140-6736},
abstract = {For more than 15 years, Norway has had the highest incidence of meningococcal disease in northern Europe, with 80\% of cases being due to serogroup B meningococci. The case-fatality has remained high, at about 10\%. In this study, an outer membrane vaccine, which had previously been shown to induce an increase in bactericidal antibodies to the parent strain, was assessed in a large-scale, randomised, double-blind trial. From October, 1988, 171,800 students in secondary schools volunteered to take part in a double-blind, placebo-controlled, efficacy trial with school as the randomisation unit. Hospitals and clinics that routinely receive patients with infectious disease were asked to report urgently all cases of suspected meningitis and/or septicaemia in 13-21-year-old students in Norway. These cases were registered and further investigated according to a detailed protocol. 89 out of the 221 cases investigated by June 3, 1991, were shown to be severe systemic disease due to group B meningococci. 36 cases in 35 schools took part in the trial (11 schools with vaccinated students and 24 with students given placebo). The calculated rate of protection was thus 57.2\% (p = 0.012, one-sided test). The findings suggest that, although the vaccine conferred protection against group B meningococcal disease, the effect was insufficient to justify a public vaccination programme.},
language = {eng},
number = {8775},
journal = {Lancet},
author = {Bjune, G. and Høiby, E. A. and Grønnesby, J. K. and Arnesen, O. and Fredriksen, J. H. and Halstensen, A. and Holten, E. and Lindbak, A. K. and Nøkleby, H. and Rosenqvist, E.},
month = nov,
year = {1991},
pmid = {1682541},
pages = {1093--1096},
}
Downloads: 0
{"_id":"9aoFMBDwEy3dNuQax","bibbaseid":"bjune-hiby-grnnesby-arnesen-fredriksen-halstensen-holten-lindbak-etal-effectofoutermembranevesiclevaccineagainstgroupbmeningococcaldiseaseinnorway-1991","author_short":["Bjune, G.","Høiby, E. A.","Grønnesby, J. K.","Arnesen, O.","Fredriksen, J. H.","Halstensen, A.","Holten, E.","Lindbak, A. K.","Nøkleby, H.","Rosenqvist, E."],"bibdata":{"bibtype":"article","type":"article","title":"Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway","volume":"338","issn":"0140-6736","abstract":"For more than 15 years, Norway has had the highest incidence of meningococcal disease in northern Europe, with 80% of cases being due to serogroup B meningococci. The case-fatality has remained high, at about 10%. In this study, an outer membrane vaccine, which had previously been shown to induce an increase in bactericidal antibodies to the parent strain, was assessed in a large-scale, randomised, double-blind trial. From October, 1988, 171,800 students in secondary schools volunteered to take part in a double-blind, placebo-controlled, efficacy trial with school as the randomisation unit. Hospitals and clinics that routinely receive patients with infectious disease were asked to report urgently all cases of suspected meningitis and/or septicaemia in 13-21-year-old students in Norway. These cases were registered and further investigated according to a detailed protocol. 89 out of the 221 cases investigated by June 3, 1991, were shown to be severe systemic disease due to group B meningococci. 36 cases in 35 schools took part in the trial (11 schools with vaccinated students and 24 with students given placebo). The calculated rate of protection was thus 57.2% (p = 0.012, one-sided test). The findings suggest that, although the vaccine conferred protection against group B meningococcal disease, the effect was insufficient to justify a public vaccination programme.","language":"eng","number":"8775","journal":"Lancet","author":[{"propositions":[],"lastnames":["Bjune"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Høiby"],"firstnames":["E.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Grønnesby"],"firstnames":["J.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Arnesen"],"firstnames":["O."],"suffixes":[]},{"propositions":[],"lastnames":["Fredriksen"],"firstnames":["J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Halstensen"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Holten"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Lindbak"],"firstnames":["A.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Nøkleby"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Rosenqvist"],"firstnames":["E."],"suffixes":[]}],"month":"November","year":"1991","pmid":"1682541","pages":"1093–1096","bibtex":"@article{bjune_effect_1991,\n\ttitle = {Effect of outer membrane vesicle vaccine against group {B} meningococcal disease in {Norway}},\n\tvolume = {338},\n\tissn = {0140-6736},\n\tabstract = {For more than 15 years, Norway has had the highest incidence of meningococcal disease in northern Europe, with 80\\% of cases being due to serogroup B meningococci. The case-fatality has remained high, at about 10\\%. In this study, an outer membrane vaccine, which had previously been shown to induce an increase in bactericidal antibodies to the parent strain, was assessed in a large-scale, randomised, double-blind trial. From October, 1988, 171,800 students in secondary schools volunteered to take part in a double-blind, placebo-controlled, efficacy trial with school as the randomisation unit. Hospitals and clinics that routinely receive patients with infectious disease were asked to report urgently all cases of suspected meningitis and/or septicaemia in 13-21-year-old students in Norway. These cases were registered and further investigated according to a detailed protocol. 89 out of the 221 cases investigated by June 3, 1991, were shown to be severe systemic disease due to group B meningococci. 36 cases in 35 schools took part in the trial (11 schools with vaccinated students and 24 with students given placebo). The calculated rate of protection was thus 57.2\\% (p = 0.012, one-sided test). The findings suggest that, although the vaccine conferred protection against group B meningococcal disease, the effect was insufficient to justify a public vaccination programme.},\n\tlanguage = {eng},\n\tnumber = {8775},\n\tjournal = {Lancet},\n\tauthor = {Bjune, G. and Høiby, E. A. and Grønnesby, J. K. and Arnesen, O. and Fredriksen, J. H. and Halstensen, A. and Holten, E. and Lindbak, A. K. and Nøkleby, H. and Rosenqvist, E.},\n\tmonth = nov,\n\tyear = {1991},\n\tpmid = {1682541},\n\tpages = {1093--1096},\n}\n\n","author_short":["Bjune, G.","Høiby, E. A.","Grønnesby, J. K.","Arnesen, O.","Fredriksen, J. H.","Halstensen, A.","Holten, E.","Lindbak, A. K.","Nøkleby, H.","Rosenqvist, E."],"key":"bjune_effect_1991","id":"bjune_effect_1991","bibbaseid":"bjune-hiby-grnnesby-arnesen-fredriksen-halstensen-holten-lindbak-etal-effectofoutermembranevesiclevaccineagainstgroupbmeningococcaldiseaseinnorway-1991","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":[],"search_terms":["effect","outer","membrane","vesicle","vaccine","against","group","meningococcal","disease","norway","bjune","høiby","grønnesby","arnesen","fredriksen","halstensen","holten","lindbak","nøkleby","rosenqvist"],"title":"Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway","year":1991}