Prognostic value of nt-probnp, and echocardiographic indices of diastolic function, in hospitalized patients with acute heart failure and preserved left ventricular ejection fraction. Blanco, R.; Ambrosio, G.; Belziti, C.; Lucas, L.; Arias, A.; D'Antonio, A.; Oberti, P.; Carluccio, E.; and Pizarro, R. International Journal of Cardiology, Elsevier.
Prognostic value of nt-probnp, and echocardiographic indices of diastolic function, in hospitalized patients with acute heart failure and preserved left ventricular ejection fraction [link]Website  abstract   bibtex   
Abstract Background Several parameters have proven useful in assessing prognosis in outpatients with heart failure with preserved ejection fraction (HFpEF). In contrast, prognostic determinants in HFpEF hospitalized for an acute event are poorly investìgated. Aim To determine the predictive value of NT-proBNP, and diastolic function (assessed by E/e'), in patients with HFpEF hospitalized for acute heart failure. Methods and results We evaluated 205 consecutive HFpEF patients admitted for acute heart failure (median age: 76[53,81], 36% male, median EF: 61 [54,77]). We assessed clinical, echocardiographic, and NT-proBNP values, on admission and at discharge. Primary end-point was the composite of all-cause death and/or HF rehospitalization. After a mean follow up of 28±10 months, 82 patients met the primary end-point; there were 30 deaths (14.6%), and 72 patients (35%) were rehospitalized for HF. By multivariable analysis, predictors of the composite end-point were: discharge E/e´ ≥14 (HR: 4.63 CI 95%: 2.71-18.2, p Conclusions In HFpEF patients hospitalized with acute heart failure, assessment of E/e´ ratio and NT-proBNP at discharge provides prognostic information on top of other variables, and allows to easily identify a population at higher risk of subsequent death or rehospitalization for heart failure, during a medium-term follow up.
@article{
 title = {Prognostic value of nt-probnp, and echocardiographic indices of diastolic function, in hospitalized patients with acute heart failure and preserved left ventricular ejection fraction},
 type = {article},
 identifiers = {[object Object]},
 keywords = {Acute heart failure,Diastolic function,Heart failure with preserved ejection fraction,Natriuretic peptides,Prognosis},
 volume = {0},
 websites = {https://www.internationaljournalofcardiology.com/article/S0167-5273(20)31955-0/fulltext#},
 publisher = {Elsevier},
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 abstract = {Abstract Background Several parameters have proven useful in assessing prognosis in outpatients with heart failure with preserved ejection fraction (HFpEF). In contrast, prognostic determinants in HFpEF hospitalized for an acute event are poorly investìgated. Aim To determine the predictive value of NT-proBNP, and diastolic function (assessed by E/e'), in patients with HFpEF hospitalized for acute heart failure. Methods and results We evaluated 205 consecutive HFpEF patients admitted for acute heart failure (median age: 76[53,81], 36% male, median EF: 61 [54,77]). We assessed clinical, echocardiographic, and NT-proBNP values, on admission and at discharge. Primary end-point was the composite of all-cause death and/or HF rehospitalization. After a mean follow up of 28±10 months, 82 patients met the primary end-point; there were 30 deaths (14.6%), and 72 patients (35%) were rehospitalized for HF. By multivariable analysis, predictors of the composite end-point were: discharge E/e´ ≥14 (HR: 4.63 CI 95%: 2.71-18.2, p Conclusions In HFpEF patients hospitalized with acute heart failure, assessment of E/e´ ratio and NT-proBNP at discharge provides prognostic information on top of other variables, and allows to easily identify a population at higher risk of subsequent death or rehospitalization for heart failure, during a medium-term follow up.},
 bibtype = {article},
 author = {Blanco, Rocio and Ambrosio, Giuseppe and Belziti, Cesar and Lucas, Luciano and Arias, Anibal and D'Antonio, Antonella and Oberti, Pablo and Carluccio, Erberto and Pizarro, Rodolfo},
 journal = {International Journal of Cardiology},
 number = {0}
}
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