@ARTICLE{Blanton1992-as,
  title    = "Norepinephrine activates potassium conductance in neurons of the
              turtle cerebral cortex",
  author   = "Blanton, K J and Kriegstein, A R",
  abstract = "Whole-cell voltage and current clamp recordings were obtained
              from cortical neurons of the pond turtle, Pseudemys scripta
              elegans. Norepinephrine (NE) induced an outward current in 50\%
              of pyramidal neurons. This current had a reversal potential of
              -88.3 +/- 3.2 mV, consistent with a K+ conductance increase, and
              had a mean amplitude of 18.3 +/- 7.2 pA at -40 mV. The ionic
              dependence and pharmacological analyses are both consistent with
              alpha 2 adrenergic receptor stimulation. Inhibition of
              Na(+)-dependent action potentials with TTX did not diminish the
              NE-induced K+ conductance, indicating that NE acts directly on
              the postsynaptic neuron. In addition to effects on postsynaptic
              conductance, NE dramatically decreased the amplitude of
              spontaneous inhibitory postsynaptic currents (IPSCs) in 55\% of
              pyramidal neurons. The decrease in spontaneous IPSCs was observed
              both in those neurons which exhibited an increase in K+
              conductance in response to NE administration (81\%) and in those
              which did not (33\%). Thus, NE modulates neuronal excitability
              both directly by activating a postsynaptic K+ conductance and
              indirectly by decreasing spontaneous IPSCs.",
  journal  = "Brain Res",
  volume   =  570,
  number   = "1-2",
  pages    = "42--48",
  month    =  jan,
  year     =  1992,
  address  = "Netherlands",
  language = "en"
}

{"_id":"8b6FM6MRC8Jp94NH3","bibbaseid":"blanton-kriegstein-norepinephrineactivatespotassiumconductanceinneuronsoftheturtlecerebralcortex-1992","author_short":["Blanton, K J","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex","author":[{"propositions":[],"lastnames":["Blanton"],"firstnames":["K","J"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"Whole-cell voltage and current clamp recordings were obtained from cortical neurons of the pond turtle, Pseudemys scripta elegans. Norepinephrine (NE) induced an outward current in 50% of pyramidal neurons. This current had a reversal potential of -88.3 +/- 3.2 mV, consistent with a K+ conductance increase, and had a mean amplitude of 18.3 +/- 7.2 pA at -40 mV. The ionic dependence and pharmacological analyses are both consistent with alpha 2 adrenergic receptor stimulation. Inhibition of Na(+)-dependent action potentials with TTX did not diminish the NE-induced K+ conductance, indicating that NE acts directly on the postsynaptic neuron. In addition to effects on postsynaptic conductance, NE dramatically decreased the amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) in 55% of pyramidal neurons. The decrease in spontaneous IPSCs was observed both in those neurons which exhibited an increase in K+ conductance in response to NE administration (81%) and in those which did not (33%). Thus, NE modulates neuronal excitability both directly by activating a postsynaptic K+ conductance and indirectly by decreasing spontaneous IPSCs.","journal":"Brain Res","volume":"570","number":"1-2","pages":"42–48","month":"January","year":"1992","address":"Netherlands","language":"en","bibtex":"@ARTICLE{Blanton1992-as,\n title = \"Norepinephrine activates potassium conductance in neurons of the\n turtle cerebral cortex\",\n author = \"Blanton, K J and Kriegstein, A R\",\n abstract = \"Whole-cell voltage and current clamp recordings were obtained\n from cortical neurons of the pond turtle, Pseudemys scripta\n elegans. Norepinephrine (NE) induced an outward current in 50\\%\n of pyramidal neurons. This current had a reversal potential of\n -88.3 +/- 3.2 mV, consistent with a K+ conductance increase, and\n had a mean amplitude of 18.3 +/- 7.2 pA at -40 mV. The ionic\n dependence and pharmacological analyses are both consistent with\n alpha 2 adrenergic receptor stimulation. Inhibition of\n Na(+)-dependent action potentials with TTX did not diminish the\n NE-induced K+ conductance, indicating that NE acts directly on\n the postsynaptic neuron. In addition to effects on postsynaptic\n conductance, NE dramatically decreased the amplitude of\n spontaneous inhibitory postsynaptic currents (IPSCs) in 55\\% of\n pyramidal neurons. The decrease in spontaneous IPSCs was observed\n both in those neurons which exhibited an increase in K+\n conductance in response to NE administration (81\\%) and in those\n which did not (33\\%). Thus, NE modulates neuronal excitability\n both directly by activating a postsynaptic K+ conductance and\n indirectly by decreasing spontaneous IPSCs.\",\n journal = \"Brain Res\",\n volume = 570,\n number = \"1-2\",\n pages = \"42--48\",\n month = jan,\n year = 1992,\n address = \"Netherlands\",\n language = \"en\"\n}\n\n","author_short":["Blanton, K J","Kriegstein, A R"],"key":"Blanton1992-as","id":"Blanton1992-as","bibbaseid":"blanton-kriegstein-norepinephrineactivatespotassiumconductanceinneuronsoftheturtlecerebralcortex-1992","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["norepinephrine","activates","potassium","conductance","neurons","turtle","cerebral","cortex","blanton","kriegstein"],"title":"Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex","year":1992}