Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex. Blanton, M G, Lo Turco, J J, & Kriegstein, A R Proc Natl Acad Sci U S A, 87(20):8027–8030, October, 1990. abstract bibtex Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.
@ARTICLE{Blanton1990-pg,
title = "Endogenous neurotransmitter activates {N-methyl-D-aspartate}
receptors on differentiating neurons in embryonic cortex",
author = "Blanton, M G and Lo Turco, J J and Kriegstein, A R",
abstract = "Before synapses form in embryonic turtle cerebral cortex, an
endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA)
channels on neurons in the cortical plate. Throughout cortical
development, these channels exhibit voltage-dependent Mg2+
blockade and are antagonized by D-2-amino-5-phosphonovaleric
acid, a selective NMDA receptor antagonist. The activation in
situ of these nonsynaptic NMDA channels demonstrates a potential
physiological substrate for control of early neuronal
differentiation.",
journal = "Proc Natl Acad Sci U S A",
volume = 87,
number = 20,
pages = "8027--8030",
month = oct,
year = 1990,
language = "en"
}
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