Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex. Blanton, M G, Lo Turco, J J, & Kriegstein, A R Proc Natl Acad Sci U S A, 87(20):8027–8030, October, 1990.
abstract   bibtex   
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.
@ARTICLE{Blanton1990-pg,
  title    = "Endogenous neurotransmitter activates {N-methyl-D-aspartate}
              receptors on differentiating neurons in embryonic cortex",
  author   = "Blanton, M G and Lo Turco, J J and Kriegstein, A R",
  abstract = "Before synapses form in embryonic turtle cerebral cortex, an
              endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA)
              channels on neurons in the cortical plate. Throughout cortical
              development, these channels exhibit voltage-dependent Mg2+
              blockade and are antagonized by D-2-amino-5-phosphonovaleric
              acid, a selective NMDA receptor antagonist. The activation in
              situ of these nonsynaptic NMDA channels demonstrates a potential
              physiological substrate for control of early neuronal
              differentiation.",
  journal  = "Proc Natl Acad Sci U S A",
  volume   =  87,
  number   =  20,
  pages    = "8027--8030",
  month    =  oct,
  year     =  1990,
  language = "en"
}

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