Preregistration: Impact of Mindfulness-based Real-time fMRI Neurofeedback on Self-Referential Processing in Depressed Adolescents: A Dosing Study. Bloom, P. A., Pagliaccio, D., Bajwa, Z., Wool, E., Zhang, J., Bauer, C. C. C., Spence, J., Kyler, M., Greene, K., Treves, I. N., Morfini, F., Durham, K., Kirshenbaum, J. S., Kim, N., Ford, N., Galfalvy, H., Simpson, B. H., Whitfield-Gabrieli, S., & Randy P. Auerbach, P. January, 2025. ![Preregistration: Impact of Mindfulness-based Real-time fMRI Neurofeedback on Self-Referential Processing in Depressed Adolescents: A Dosing Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Major depressive disorder is a leading cause of disability among adolescents. Perseverative negative self-referential thoughts are a promising treatment target. Mindfulness-based real-time fMRI neurofeedback (mbNF), which guides mindfulness practice with feedback to train the downregulation of the default mode network (DMN), is an intervention targeting such negative self-referential thoughts. This study builds on a registered NIMH-supported trial testing the optimal dosing of mbNF on downregulating DMN activation among depressed adolescents. Adolescents (N=90), ages 13-18-years-old, with major depressive disorder will be randomized to receive either a 15- or 30-minute mbNF session. Before and after mbNF, participants will complete a self-referential encoding fMRI task, wherein they categorize whether trait adjectives describe themselves or a friend. It is hypothesized that a 30-minute versus 15-minute mbNF dose will relate to: (1) larger decreases in behavioral negative self-referential biases and (2) larger decreases in DMN activation during self-referential processing.
@misc{bloom_preregistration_2025,
title = {Preregistration: {Impact} of {Mindfulness}-based {Real}-time {fMRI} {Neurofeedback} on {Self}-{Referential} {Processing} in {Depressed} {Adolescents}: {A} {Dosing} {Study}},
copyright = {All rights reserved},
shorttitle = {Preregistration},
url = {https://osf.io/dshcm_v1},
doi = {10.31234/osf.io/dshcm},
abstract = {Major depressive disorder is a leading cause of disability among adolescents. Perseverative negative self-referential thoughts are a promising treatment target. Mindfulness-based real-time fMRI neurofeedback (mbNF), which guides mindfulness practice with feedback to train the downregulation of the default mode network (DMN), is an intervention targeting such negative self-referential thoughts. This study builds on a registered NIMH-supported trial testing the optimal dosing of mbNF on downregulating DMN activation among depressed adolescents. Adolescents (N=90), ages 13-18-years-old, with major depressive disorder will be randomized to receive either a 15- or 30-minute mbNF session. Before and after mbNF, participants will complete a self-referential encoding fMRI task, wherein they categorize whether trait adjectives describe themselves or a friend. It is hypothesized that a 30-minute versus 15-minute mbNF dose will relate to: (1) larger decreases in behavioral negative self-referential biases and (2) larger decreases in DMN activation during self-referential processing.},
language = {en-us},
urldate = {2025-02-20},
publisher = {OSF},
author = {Bloom, Paul Alexander and Pagliaccio, David and Bajwa, Zia and Wool, Emma and Zhang, Jiahe and Bauer, Clemens C. C. and Spence, Jamaal and Kyler, Mia and Greene, Keara and Treves, Isaac N. and Morfini, Francesca and Durham, Katherine and Kirshenbaum, Jaclyn Schwartz and Kim, Nayoung and Ford, Nicholas and Galfalvy, Hanga and Simpson, Blair H. and Whitfield-Gabrieli, Susan and Randy P. Auerbach, PhD},
month = jan,
year = {2025},
keywords = {neurofeedback, fmri, mindfulness, rumination, dmn, self-referential processing, sret},
file = {OSF Preprint:/Users/mexico/Zotero/storage/Y8C7YB36/Bloom et al. - 2025 - Preregistration Impact of Mindfulness-based Prere.pdf:application/pdf},
}
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