Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. Blumcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C. G., Pfäfflin, M., Elger, C., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, J. C., Aronica, E., Chassoux, F., Hamer, H., Stefan, H., Rössler, K., Thom, M., Walker, M. C., Sisodiya, S. M., Duncan, J. S., McEvoy, A. W., Pieper, T., Holthausen, H., Kudernatsch, M., Meencke, H. J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D. H., Urbach, H., Steinhoff, B. J., Bast, T., Tassi, L., Lo Russo, G., Özkara, C., Oz, B., Krsek, P., Vogelgesang, S., Runge, U., Lerche, H., Weber, Y., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., Schijns, O., Guerrini, R., Barba, C., Jacques, T. S., Cross, J. H., Feucht, M., Mühlebner, A., Grunwald, T., Trinka, E., Winkler, P. A., Gil-Nagel, A., Toledano Delgado, R., Mayer, T., Lutz, M., Zountsas, B., Garganis, K., Rosenow, F., Hermsen, A., von Oertzen, T. J., Diepgen, T. L., Avanzini, G., & EEBB Consortium The New England Journal of Medicine, 377(17):1648–1656, 2017. doi abstract bibtex BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).
@article{blumcke_histopathological_2017,
title = {Histopathological {Findings} in {Brain} {Tissue} {Obtained} during {Epilepsy} {Surgery}},
volume = {377},
issn = {1533-4406},
doi = {10.1056/NEJMoa1703784},
abstract = {BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.
METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41\%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59\%).
RESULTS: The onset of seizures occurred before 18 years of age in 75.9\% of patients overall, and 72.5\% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9\% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4\% of the patients (88.7\% of cases were in adults), tumors (mainly ganglioglioma) in 23.6\%, and malformations of cortical development in 19.8\% (focal cortical dysplasia was the most common type, 52.7\% of cases of which were in children). No histopathological diagnosis could be established for 7.7\% of the patients.
CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).},
language = {eng},
number = {17},
journal = {The New England Journal of Medicine},
author = {Blumcke, Ingmar and Spreafico, Roberto and Haaker, Gerrit and Coras, Roland and Kobow, Katja and Bien, Christian G. and Pfäfflin, Margarete and Elger, Christian and Widman, Guido and Schramm, Johannes and Becker, Albert and Braun, Kees P. and Leijten, Frans and Baayen, Johannes C. and Aronica, Eleonora and Chassoux, Francine and Hamer, Hajo and Stefan, Hermann and Rössler, Karl and Thom, Maria and Walker, Matthew C. and Sisodiya, Sanjay M. and Duncan, John S. and McEvoy, Andrew W. and Pieper, Tom and Holthausen, Hans and Kudernatsch, Manfred and Meencke, H. Joachim and Kahane, Philippe and Schulze-Bonhage, Andreas and Zentner, Josef and Heiland, Dieter H. and Urbach, Horst and Steinhoff, Bernhard J. and Bast, Thomas and Tassi, Laura and Lo Russo, Giorgio and Özkara, Cigdem and Oz, Buge and Krsek, Pavel and Vogelgesang, Silke and Runge, Uwe and Lerche, Holger and Weber, Yvonne and Honavar, Mrinalini and Pimentel, José and Arzimanoglou, Alexis and Ulate-Campos, Adriana and Noachtar, Soheyl and Hartl, Elisabeth and Schijns, Olaf and Guerrini, Renzo and Barba, Carmen and Jacques, Thomas S. and Cross, J. Helen and Feucht, Martha and Mühlebner, Angelika and Grunwald, Thomas and Trinka, Eugen and Winkler, Peter A. and Gil-Nagel, Antonio and Toledano Delgado, Rafael and Mayer, Thomas and Lutz, Martin and Zountsas, Basilios and Garganis, Kyriakos and Rosenow, Felix and Hermsen, Anke and von Oertzen, Tim J. and Diepgen, Thomas L. and Avanzini, Giuliano and {EEBB Consortium}},
year = {2017},
pmid = {29069555},
keywords = {Adult, Age Factors, Age of Onset, Brain, Brain Neoplasms, Child, Databases as Topic, Epilepsy, Europe, Female, Hippocampus, Humans, Male, Malformations of Cortical Development, Temporal Lobe},
pages = {1648--1656},
}
Downloads: 0
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H.","Feucht, M.","Mühlebner, A.","Grunwald, T.","Trinka, E.","Winkler, P. A.","Gil-Nagel, A.","Toledano Delgado, R.","Mayer, T.","Lutz, M.","Zountsas, B.","Garganis, K.","Rosenow, F.","Hermsen, A.","von Oertzen, T. J.","Diepgen, T. L.","Avanzini, G.","EEBB Consortium"],"bibdata":{"bibtype":"article","type":"article","title":"Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery","volume":"377","issn":"1533-4406","doi":"10.1056/NEJMoa1703784","abstract":"BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).","language":"eng","number":"17","journal":"The New England Journal of Medicine","author":[{"propositions":[],"lastnames":["Blumcke"],"firstnames":["Ingmar"],"suffixes":[]},{"propositions":[],"lastnames":["Spreafico"],"firstnames":["Roberto"],"suffixes":[]},{"propositions":[],"lastnames":["Haaker"],"firstnames":["Gerrit"],"suffixes":[]},{"propositions":[],"lastnames":["Coras"],"firstnames":["Roland"],"suffixes":[]},{"propositions":[],"lastnames":["Kobow"],"firstnames":["Katja"],"suffixes":[]},{"propositions":[],"lastnames":["Bien"],"firstnames":["Christian","G."],"suffixes":[]},{"propositions":[],"lastnames":["Pfäfflin"],"firstnames":["Margarete"],"suffixes":[]},{"propositions":[],"lastnames":["Elger"],"firstnames":["Christian"],"suffixes":[]},{"propositions":[],"lastnames":["Widman"],"firstnames":["Guido"],"suffixes":[]},{"propositions":[],"lastnames":["Schramm"],"firstnames":["Johannes"],"suffixes":[]},{"propositions":[],"lastnames":["Becker"],"firstnames":["Albert"],"suffixes":[]},{"propositions":[],"lastnames":["Braun"],"firstnames":["Kees","P."],"suffixes":[]},{"propositions":[],"lastnames":["Leijten"],"firstnames":["Frans"],"suffixes":[]},{"propositions":[],"lastnames":["Baayen"],"firstnames":["Johannes","C."],"suffixes":[]},{"propositions":[],"lastnames":["Aronica"],"firstnames":["Eleonora"],"suffixes":[]},{"propositions":[],"lastnames":["Chassoux"],"firstnames":["Francine"],"suffixes":[]},{"propositions":[],"lastnames":["Hamer"],"firstnames":["Hajo"],"suffixes":[]},{"propositions":[],"lastnames":["Stefan"],"firstnames":["Hermann"],"suffixes":[]},{"propositions":[],"lastnames":["Rössler"],"firstnames":["Karl"],"suffixes":[]},{"propositions":[],"lastnames":["Thom"],"firstnames":["Maria"],"suffixes":[]},{"propositions":[],"lastnames":["Walker"],"firstnames":["Matthew","C."],"suffixes":[]},{"propositions":[],"lastnames":["Sisodiya"],"firstnames":["Sanjay","M."],"suffixes":[]},{"propositions":[],"lastnames":["Duncan"],"firstnames":["John","S."],"suffixes":[]},{"propositions":[],"lastnames":["McEvoy"],"firstnames":["Andrew","W."],"suffixes":[]},{"propositions":[],"lastnames":["Pieper"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Holthausen"],"firstnames":["Hans"],"suffixes":[]},{"propositions":[],"lastnames":["Kudernatsch"],"firstnames":["Manfred"],"suffixes":[]},{"propositions":[],"lastnames":["Meencke"],"firstnames":["H.","Joachim"],"suffixes":[]},{"propositions":[],"lastnames":["Kahane"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Schulze-Bonhage"],"firstnames":["Andreas"],"suffixes":[]},{"propositions":[],"lastnames":["Zentner"],"firstnames":["Josef"],"suffixes":[]},{"propositions":[],"lastnames":["Heiland"],"firstnames":["Dieter","H."],"suffixes":[]},{"propositions":[],"lastnames":["Urbach"],"firstnames":["Horst"],"suffixes":[]},{"propositions":[],"lastnames":["Steinhoff"],"firstnames":["Bernhard","J."],"suffixes":[]},{"propositions":[],"lastnames":["Bast"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Tassi"],"firstnames":["Laura"],"suffixes":[]},{"propositions":[],"lastnames":["Lo","Russo"],"firstnames":["Giorgio"],"suffixes":[]},{"propositions":[],"lastnames":["Özkara"],"firstnames":["Cigdem"],"suffixes":[]},{"propositions":[],"lastnames":["Oz"],"firstnames":["Buge"],"suffixes":[]},{"propositions":[],"lastnames":["Krsek"],"firstnames":["Pavel"],"suffixes":[]},{"propositions":[],"lastnames":["Vogelgesang"],"firstnames":["Silke"],"suffixes":[]},{"propositions":[],"lastnames":["Runge"],"firstnames":["Uwe"],"suffixes":[]},{"propositions":[],"lastnames":["Lerche"],"firstnames":["Holger"],"suffixes":[]},{"propositions":[],"lastnames":["Weber"],"firstnames":["Yvonne"],"suffixes":[]},{"propositions":[],"lastnames":["Honavar"],"firstnames":["Mrinalini"],"suffixes":[]},{"propositions":[],"lastnames":["Pimentel"],"firstnames":["José"],"suffixes":[]},{"propositions":[],"lastnames":["Arzimanoglou"],"firstnames":["Alexis"],"suffixes":[]},{"propositions":[],"lastnames":["Ulate-Campos"],"firstnames":["Adriana"],"suffixes":[]},{"propositions":[],"lastnames":["Noachtar"],"firstnames":["Soheyl"],"suffixes":[]},{"propositions":[],"lastnames":["Hartl"],"firstnames":["Elisabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Schijns"],"firstnames":["Olaf"],"suffixes":[]},{"propositions":[],"lastnames":["Guerrini"],"firstnames":["Renzo"],"suffixes":[]},{"propositions":[],"lastnames":["Barba"],"firstnames":["Carmen"],"suffixes":[]},{"propositions":[],"lastnames":["Jacques"],"firstnames":["Thomas","S."],"suffixes":[]},{"propositions":[],"lastnames":["Cross"],"firstnames":["J.","Helen"],"suffixes":[]},{"propositions":[],"lastnames":["Feucht"],"firstnames":["Martha"],"suffixes":[]},{"propositions":[],"lastnames":["Mühlebner"],"firstnames":["Angelika"],"suffixes":[]},{"propositions":[],"lastnames":["Grunwald"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Trinka"],"firstnames":["Eugen"],"suffixes":[]},{"propositions":[],"lastnames":["Winkler"],"firstnames":["Peter","A."],"suffixes":[]},{"propositions":[],"lastnames":["Gil-Nagel"],"firstnames":["Antonio"],"suffixes":[]},{"propositions":[],"lastnames":["Toledano","Delgado"],"firstnames":["Rafael"],"suffixes":[]},{"propositions":[],"lastnames":["Mayer"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Lutz"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Zountsas"],"firstnames":["Basilios"],"suffixes":[]},{"propositions":[],"lastnames":["Garganis"],"firstnames":["Kyriakos"],"suffixes":[]},{"propositions":[],"lastnames":["Rosenow"],"firstnames":["Felix"],"suffixes":[]},{"propositions":[],"lastnames":["Hermsen"],"firstnames":["Anke"],"suffixes":[]},{"propositions":["von"],"lastnames":["Oertzen"],"firstnames":["Tim","J."],"suffixes":[]},{"propositions":[],"lastnames":["Diepgen"],"firstnames":["Thomas","L."],"suffixes":[]},{"propositions":[],"lastnames":["Avanzini"],"firstnames":["Giuliano"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["EEBB Consortium"],"suffixes":[]}],"year":"2017","pmid":"29069555","keywords":"Adult, Age Factors, Age of Onset, Brain, Brain Neoplasms, Child, Databases as Topic, Epilepsy, Europe, Female, Hippocampus, Humans, Male, Malformations of Cortical Development, Temporal Lobe","pages":"1648–1656","bibtex":"@article{blumcke_histopathological_2017,\n\ttitle = {Histopathological {Findings} in {Brain} {Tissue} {Obtained} during {Epilepsy} {Surgery}},\n\tvolume = {377},\n\tissn = {1533-4406},\n\tdoi = {10.1056/NEJMoa1703784},\n\tabstract = {BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.\nMETHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41\\%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59\\%).\nRESULTS: The onset of seizures occurred before 18 years of age in 75.9\\% of patients overall, and 72.5\\% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9\\% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4\\% of the patients (88.7\\% of cases were in adults), tumors (mainly ganglioglioma) in 23.6\\%, and malformations of cortical development in 19.8\\% (focal cortical dysplasia was the most common type, 52.7\\% of cases of which were in children). No histopathological diagnosis could be established for 7.7\\% of the patients.\nCONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).},\n\tlanguage = {eng},\n\tnumber = {17},\n\tjournal = {The New England Journal of Medicine},\n\tauthor = {Blumcke, Ingmar and Spreafico, Roberto and Haaker, Gerrit and Coras, Roland and Kobow, Katja and Bien, Christian G. and Pfäfflin, Margarete and Elger, Christian and Widman, Guido and Schramm, Johannes and Becker, Albert and Braun, Kees P. and Leijten, Frans and Baayen, Johannes C. and Aronica, Eleonora and Chassoux, Francine and Hamer, Hajo and Stefan, Hermann and Rössler, Karl and Thom, Maria and Walker, Matthew C. and Sisodiya, Sanjay M. and Duncan, John S. and McEvoy, Andrew W. and Pieper, Tom and Holthausen, Hans and Kudernatsch, Manfred and Meencke, H. Joachim and Kahane, Philippe and Schulze-Bonhage, Andreas and Zentner, Josef and Heiland, Dieter H. and Urbach, Horst and Steinhoff, Bernhard J. and Bast, Thomas and Tassi, Laura and Lo Russo, Giorgio and Özkara, Cigdem and Oz, Buge and Krsek, Pavel and Vogelgesang, Silke and Runge, Uwe and Lerche, Holger and Weber, Yvonne and Honavar, Mrinalini and Pimentel, José and Arzimanoglou, Alexis and Ulate-Campos, Adriana and Noachtar, Soheyl and Hartl, Elisabeth and Schijns, Olaf and Guerrini, Renzo and Barba, Carmen and Jacques, Thomas S. and Cross, J. Helen and Feucht, Martha and Mühlebner, Angelika and Grunwald, Thomas and Trinka, Eugen and Winkler, Peter A. and Gil-Nagel, Antonio and Toledano Delgado, Rafael and Mayer, Thomas and Lutz, Martin and Zountsas, Basilios and Garganis, Kyriakos and Rosenow, Felix and Hermsen, Anke and von Oertzen, Tim J. and Diepgen, Thomas L. and Avanzini, Giuliano and {EEBB Consortium}},\n\tyear = {2017},\n\tpmid = {29069555},\n\tkeywords = {Adult, Age Factors, Age of Onset, Brain, Brain Neoplasms, Child, Databases as Topic, Epilepsy, Europe, Female, Hippocampus, Humans, Male, Malformations of Cortical Development, Temporal Lobe},\n\tpages = {1648--1656},\n}\n\n\n\n","author_short":["Blumcke, I.","Spreafico, R.","Haaker, G.","Coras, R.","Kobow, K.","Bien, C. G.","Pfäfflin, M.","Elger, C.","Widman, G.","Schramm, J.","Becker, A.","Braun, K. P.","Leijten, F.","Baayen, J. C.","Aronica, E.","Chassoux, F.","Hamer, H.","Stefan, H.","Rössler, K.","Thom, M.","Walker, M. C.","Sisodiya, S. M.","Duncan, J. S.","McEvoy, A. W.","Pieper, T.","Holthausen, H.","Kudernatsch, M.","Meencke, H. J.","Kahane, P.","Schulze-Bonhage, A.","Zentner, J.","Heiland, D. H.","Urbach, H.","Steinhoff, B. J.","Bast, T.","Tassi, L.","Lo Russo, G.","Özkara, C.","Oz, B.","Krsek, P.","Vogelgesang, S.","Runge, U.","Lerche, H.","Weber, Y.","Honavar, M.","Pimentel, J.","Arzimanoglou, A.","Ulate-Campos, A.","Noachtar, S.","Hartl, E.","Schijns, O.","Guerrini, R.","Barba, C.","Jacques, T. S.","Cross, J. H.","Feucht, M.","Mühlebner, A.","Grunwald, T.","Trinka, E.","Winkler, P. A.","Gil-Nagel, A.","Toledano Delgado, R.","Mayer, T.","Lutz, M.","Zountsas, B.","Garganis, K.","Rosenow, F.","Hermsen, A.","von Oertzen, T. J.","Diepgen, T. L.","Avanzini, G.","EEBB Consortium"],"key":"blumcke_histopathological_2017","id":"blumcke_histopathological_2017","bibbaseid":"blumcke-spreafico-haaker-coras-kobow-bien-pffflin-elger-etal-histopathologicalfindingsinbraintissueobtainedduringepilepsysurgery-2017","role":"author","urls":{},"keyword":["Adult","Age Factors","Age of Onset","Brain","Brain Neoplasms","Child","Databases as Topic","Epilepsy","Europe","Female","Hippocampus","Humans","Male","Malformations of Cortical Development","Temporal Lobe"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/lconcha","dataSources":["vCGHbq7YMoL4xbgTv"],"keywords":["adult","age factors","age of onset","brain","brain neoplasms","child","databases as topic","epilepsy","europe","female","hippocampus","humans","male","malformations of cortical development","temporal lobe"],"search_terms":["histopathological","findings","brain","tissue","obtained","during","epilepsy","surgery","blumcke","spreafico","haaker","coras","kobow","bien","pfäfflin","elger","widman","schramm","becker","braun","leijten","baayen","aronica","chassoux","hamer","stefan","rössler","thom","walker","sisodiya","duncan","mcevoy","pieper","holthausen","kudernatsch","meencke","kahane","schulze-bonhage","zentner","heiland","urbach","steinhoff","bast","tassi","lo russo","özkara","oz","krsek","vogelgesang","runge","lerche","weber","honavar","pimentel","arzimanoglou","ulate-campos","noachtar","hartl","schijns","guerrini","barba","jacques","cross","feucht","mühlebner","grunwald","trinka","winkler","gil-nagel","toledano delgado","mayer","lutz","zountsas","garganis","rosenow","hermsen","von oertzen","diepgen","avanzini","eebb consortium"],"title":"Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery","year":2017}