Cellular basis for response diversity in the olfactory periphery. Bobkov, Y., Park, I., Ukhanov, K., Príncipe, J. C., & Ache, B. W. PLoS One, 7(4):e34843+, April, 2012. doi abstract bibtex An emerging idea in olfaction is that temporal coding of odor specificity can be intrinsic to the primary olfactory receptor neurons (ORNs). As a first step towards understanding whether lobster ORNs are capable of generating odor-specific temporal activity and what mechanisms underlie any such heterogeneity in discharge pattern, we characterized different patterns of activity in lobster ORNs individually and ensemble using patch-clamp recording and calcium imaging. We demonstrate that lobster ORNs show tonic excitation, tonic inhibition, phaso-tonic excitation, and bursting, and that these patterns are faithfully reflected in the calcium signal. We then demonstrate that the various dynamic patterns of response are inherent in the cells, and that this inherent heterogeneity is largely determined by heterogeneity in the underlying intrinsic conductances.
@ARTICLE{Bobkov2012a,
author = {Yuriy Bobkov and Il Park and Kirill Ukhanov and Jos\'e C. Pr\'incipe
and Barry W. Ache},
title = {Cellular basis for response diversity in the olfactory periphery},
journal = {PLoS One},
year = {2012},
volume = {7},
pages = {e34843+},
number = {4},
month = apr,
abstract = {An emerging idea in olfaction is that temporal coding of odor specificity
can be intrinsic to the primary olfactory receptor neurons ({ORNs}).
As a first step towards understanding whether lobster {ORNs} are
capable of generating odor-specific temporal activity and what mechanisms
underlie any such heterogeneity in discharge pattern, we characterized
different patterns of activity in lobster {ORNs} individually and
ensemble using patch-clamp recording and calcium imaging. We demonstrate
that lobster {ORNs} show tonic excitation, tonic inhibition, phaso-tonic
excitation, and bursting, and that these patterns are faithfully
reflected in the calcium signal. We then demonstrate that the various
dynamic patterns of response are inherent in the cells, and that
this inherent heterogeneity is largely determined by heterogeneity
in the underlying intrinsic conductances.},
day = {13},
doi = {10.1371/journal.pone.0034843}
}
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