@article{Bohrer2021,
abstract = {Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.},
author = {Bohrer, Andrea C and Castro, Ehydel and Hu, Zhidong and Queiroz, Artur T L and Tocheny, Claire E and Assmann, Maike and Sakai, Shunsuke and Nelson, Christine and Baker, Paul J and Ma, Hui and Wang, Lin and Zilu, Wen and {Du Bruyn}, Elsa and Riou, Catherine and Kauffman, Keith D and Program, Tuberculosis Imaging and Moore, Ian N and {Del Nonno}, Franca and Petrone, Linda and Goletti, Delia and Martineau, Adrian R and Lowe, David M and Cronan, Mark R and Wilkinson, Robert J and Barry, Clifton E and Via, Laura E and Barber, Daniel L and Klion, Amy D and Andrade, Bruno B and Song, Yanzheng and Wong, Ka-Wing and Mayer-Barber, Katrin D},
doi = {10.1084/JEM.20210469},
issn = {0022-1007},
journal = {Journal of Experimental Medicine},
keywords = {OA,eosinophils,flow cytometry,fund{\_}ack,granulocytes,granuloma,host (organism),infections,lung,macaca mulatta,mice,original,primates,tuberculosis},
mendeley-tags = {OA,fund{\_}ack,original},
month = {oct},
number = {10},
pages = {e20210469},
pmid = {34347010},
publisher = {The Rockefeller University Press},
title = {{Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice}},
url = {https://rupress.org/jem/article/218/10/e20210469/212535/Eosinophils-are-part-of-the-granulocyte-response},
volume = {218},
year = {2021}
}

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Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. 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