@article{boldescu_broad-spectrum_2017,
	title = {Broad-spectrum agents for flaviviral infections: {Dengue}, {Zika} and beyond},
	volume = {16},
	issn = {14741784},
	url = {http://dx.doi.org/10.1038/nrd.2017.33},
	doi = {10.1038/nrd.2017.33},
	abstract = {Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets.},
	number = {8},
	journal = {Nature Reviews Drug Discovery},
	author = {Boldescu, Veaceslav and Behnam, Mira A. M. and Vasilakis, Nikos and Klein, Christian D.},
	year = {2017},
	pmid = {28473729},
	note = {Publisher: Nature Publishing Group},
	pages = {565--586},
}

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