Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease. Boldt, A., Wetzel, U., Lauschke, J., Weigl, J., Gummert, J., Hindricks, G., Kottkamp, H., & Dhein, S. Heart, 90(4):400–405, April, 2004. bibtex @Article{RSM:Bol2004,
author = "A. Boldt and U. Wetzel and J. Lauschke and J. Weigl
and J. Gummert and G. Hindricks and H. Kottkamp and S.
Dhein",
title = "Fibrosis in left atrial tissue of patients with atrial
fibrillation with and without underlying mitral valve
disease.",
journal = "Heart",
year = "2004",
month = apr,
volume = "90",
number = "4",
pages = "400--405",
robnote = "afib OBJECTIVE: To examine the hypothesis that major
extracellular matrix (ECM) proteins are expressed
differently in the left atrial tissue of patients in
sinus rhythm (SR), lone atrial fibrillation (AF), and
AF with underlying mitral valve disease (MVD). DESIGN:
Case-control study. PATIENTS: 118 patients with lone
AF, MVD+AF, and SR. MAIN OUTCOME MEASURES: Collagen I,
collagen III, and fibronectin protein expression
measured by quantitative western blotting techniques
and immunohistochemical methods. RESULTS: Protein
concentrations increased in patients with AF (all
forms) compared with those in SR (all forms): collagen
I (1.15 (0.11) v 0.45 (0.28), respectively; p = 0.002),
collagen III (0.74 (0.05) v 0.46 (0.11); p = 0.002, and
fibronectin (0.88 (0.06) v 0.62 (0.13); p = 0.08).
Especially, collagen I was similarly enhanced in both
lone AF (1.49 (0.15) and MVD+AF (1.53 (0.16) compared
with SR (0.56 (0.28); both p = 0.01). Collagen III was
not significantly increased in lone AF but was
significantly increased in AF combined with MVD (0.84
(0.07) both compared with SR (0.46 (0.11); p = 0.01).
The concentration of fibronectin was not significantly
increased in lone AF and MVD+AF (both compared with
SR). Furthermore, there was a similar degree of
enhanced collagen expression in paroxysmal AF and
chronic AF. CONCLUSIONS: AF is associated with
fibrosis. Forms of AF differ from each other in
collagen III expression. However, there was no
systematic difference in ECM expression between
paroxysmal AF and chronic AF. Enhanced concentrations
of ECM proteins may have a role in structural
remodelling and the pathogenesis of AF as a result of
separation of the cells by fibrotic depositions.",
bibdate = "Sun Jun 1 18:41:50 2008",
}
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{"_id":"WjQqjsDEdHsiPZwue","bibbaseid":"boldt-wetzel-lauschke-weigl-gummert-hindricks-kottkamp-dhein-fibrosisinleftatrialtissueofpatientswithatrialfibrillationwithandwithoutunderlyingmitralvalvedisease-2004","downloads":0,"creationDate":"2016-07-01T21:38:30.512Z","title":"Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease.","author_short":["Boldt, A.","Wetzel, U.","Lauschke, J.","Weigl, J.","Gummert, J.","Hindricks, G.","Kottkamp, H.","Dhein, S."],"year":2004,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["A."],"propositions":[],"lastnames":["Boldt"],"suffixes":[]},{"firstnames":["U."],"propositions":[],"lastnames":["Wetzel"],"suffixes":[]},{"firstnames":["J."],"propositions":[],"lastnames":["Lauschke"],"suffixes":[]},{"firstnames":["J."],"propositions":[],"lastnames":["Weigl"],"suffixes":[]},{"firstnames":["J."],"propositions":[],"lastnames":["Gummert"],"suffixes":[]},{"firstnames":["G."],"propositions":[],"lastnames":["Hindricks"],"suffixes":[]},{"firstnames":["H."],"propositions":[],"lastnames":["Kottkamp"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Dhein"],"suffixes":[]}],"title":"Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease.","journal":"Heart","year":"2004","month":"April","volume":"90","number":"4","pages":"400–405","robnote":"afib OBJECTIVE: To examine the hypothesis that major extracellular matrix (ECM) proteins are expressed differently in the left atrial tissue of patients in sinus rhythm (SR), lone atrial fibrillation (AF), and AF with underlying mitral valve disease (MVD). DESIGN: Case-control study. PATIENTS: 118 patients with lone AF, MVD+AF, and SR. MAIN OUTCOME MEASURES: Collagen I, collagen III, and fibronectin protein expression measured by quantitative western blotting techniques and immunohistochemical methods. RESULTS: Protein concentrations increased in patients with AF (all forms) compared with those in SR (all forms): collagen I (1.15 (0.11) v 0.45 (0.28), respectively; p = 0.002), collagen III (0.74 (0.05) v 0.46 (0.11); p = 0.002, and fibronectin (0.88 (0.06) v 0.62 (0.13); p = 0.08). Especially, collagen I was similarly enhanced in both lone AF (1.49 (0.15) and MVD+AF (1.53 (0.16) compared with SR (0.56 (0.28); both p = 0.01). Collagen III was not significantly increased in lone AF but was significantly increased in AF combined with MVD (0.84 (0.07) both compared with SR (0.46 (0.11); p = 0.01). The concentration of fibronectin was not significantly increased in lone AF and MVD+AF (both compared with SR). Furthermore, there was a similar degree of enhanced collagen expression in paroxysmal AF and chronic AF. CONCLUSIONS: AF is associated with fibrosis. Forms of AF differ from each other in collagen III expression. However, there was no systematic difference in ECM expression between paroxysmal AF and chronic AF. Enhanced concentrations of ECM proteins may have a role in structural remodelling and the pathogenesis of AF as a result of separation of the cells by fibrotic depositions.","bibdate":"Sun Jun 1 18:41:50 2008","bibtex":"@Article{RSM:Bol2004,\n author = \"A. Boldt and U. Wetzel and J. Lauschke and J. Weigl\n and J. Gummert and G. Hindricks and H. Kottkamp and S.\n Dhein\",\n title = \"Fibrosis in left atrial tissue of patients with atrial\n fibrillation with and without underlying mitral valve\n disease.\",\n journal = \"Heart\",\n year = \"2004\",\n month = apr,\n volume = \"90\",\n number = \"4\",\n pages = \"400--405\",\n robnote = \"afib OBJECTIVE: To examine the hypothesis that major\n extracellular matrix (ECM) proteins are expressed\n differently in the left atrial tissue of patients in\n sinus rhythm (SR), lone atrial fibrillation (AF), and\n AF with underlying mitral valve disease (MVD). DESIGN:\n Case-control study. PATIENTS: 118 patients with lone\n AF, MVD+AF, and SR. MAIN OUTCOME MEASURES: Collagen I,\n collagen III, and fibronectin protein expression\n measured by quantitative western blotting techniques\n and immunohistochemical methods. RESULTS: Protein\n concentrations increased in patients with AF (all\n forms) compared with those in SR (all forms): collagen\n I (1.15 (0.11) v 0.45 (0.28), respectively; p = 0.002),\n collagen III (0.74 (0.05) v 0.46 (0.11); p = 0.002, and\n fibronectin (0.88 (0.06) v 0.62 (0.13); p = 0.08).\n Especially, collagen I was similarly enhanced in both\n lone AF (1.49 (0.15) and MVD+AF (1.53 (0.16) compared\n with SR (0.56 (0.28); both p = 0.01). Collagen III was\n not significantly increased in lone AF but was\n significantly increased in AF combined with MVD (0.84\n (0.07) both compared with SR (0.46 (0.11); p = 0.01).\n The concentration of fibronectin was not significantly\n increased in lone AF and MVD+AF (both compared with\n SR). Furthermore, there was a similar degree of\n enhanced collagen expression in paroxysmal AF and\n chronic AF. CONCLUSIONS: AF is associated with\n fibrosis. Forms of AF differ from each other in\n collagen III expression. However, there was no\n systematic difference in ECM expression between\n paroxysmal AF and chronic AF. Enhanced concentrations\n of ECM proteins may have a role in structural\n remodelling and the pathogenesis of AF as a result of\n separation of the cells by fibrotic depositions.\",\n bibdate = \"Sun Jun 1 18:41:50 2008\",\n}\n\n\n","author_short":["Boldt, A.","Wetzel, U.","Lauschke, J.","Weigl, J.","Gummert, J.","Hindricks, G.","Kottkamp, H.","Dhein, S."],"key":"RSM:Bol2004","id":"RSM:Bol2004","bibbaseid":"boldt-wetzel-lauschke-weigl-gummert-hindricks-kottkamp-dhein-fibrosisinleftatrialtissueofpatientswithatrialfibrillationwithandwithoutunderlyingmitralvalvedisease-2004","role":"author","urls":{},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["fibrosis","left","atrial","tissue","patients","atrial","fibrillation","without","underlying","mitral","valve","disease","boldt","wetzel","lauschke","weigl","gummert","hindricks","kottkamp","dhein"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}