@article{borgatta_infections_2017,
	title = {Infections in intensive care unit adult patients harboring multidrug-resistant {Pseudomonas} aeruginosa: implications for prevention and therapy},
	volume = {36},
	issn = {14354373},
	doi = {10.1007/s10096-016-2894-3},
	abstract = {The purpose of this paper was to report the burden and characteristics of infection by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in clinical samples from intensive care unit (ICU) adults, and to identify predictors. This was a retrospective observational study at four medical-surgical ICUs. The case cohort comprised adults with documented isolation of an MDR-PA strain from a clinical specimen during ICU stay. Multivariate analysis was performed to identify predictors for MDR-PA infection. During the study period, 5667 patients were admitted to the ICU and P. aeruginosa was isolated in 504 (8.8\%). MDR-PA was identified in 142 clinical samples from 104 patients (20.6\%); 62 (43.6\%) of these samples appeared to be true infections. One hundred and eighteen (83.1\%) isolates were susceptible only to amikacin and colistin, and 13 (9.2\%) were susceptible only to colistin. Overall, the MIC50 to meropenem was 16 μg/mL and the MIC90 was {\textgreater}32 μg/mL, with 60.4\% of respiratory samples being MIC {\textgreater}32 μg/mL to meropenem. Independent predictors for MDR-PA infection were fever/hypothermia [odds ratio (OR) 9.09], recent antipseudomonal cephalosporin therapy (OR 6.31), vasopressors at infection onset (OR 4.40), and PIRO (predisposition, infection, response, and organ dysfunction) score {\textgreater}2 (OR 2.06). This study provides novel information that may be of use for the clinical management of patients harboring MDR-PA and for the control of the spread of this organism.},
	number = {7},
	journal = {European Journal of Clinical Microbiology and Infectious Diseases},
	author = {Borgatta, B. and Lagunes, L. and Imbiscuso, A. T. and Larrosa, M. N. and Lujàn, M. and Rello, J.},
	month = jul,
	year = {2017},
	pmid = {28093651},
	note = {Publisher: Springer Verlag},
	pages = {1097--1104},
}

{"_id":"szDCoDoN6NwGPGPRe","bibbaseid":"borgatta-lagunes-imbiscuso-larrosa-lujn-rello-infectionsinintensivecareunitadultpatientsharboringmultidrugresistantpseudomonasaeruginosaimplicationsforpreventionandtherapy-2017","author_short":["Borgatta, B.","Lagunes, L.","Imbiscuso, A. T.","Larrosa, M. N.","Lujàn, M.","Rello, J."],"bibdata":{"bibtype":"article","type":"article","title":"Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy","volume":"36","issn":"14354373","doi":"10.1007/s10096-016-2894-3","abstract":"The purpose of this paper was to report the burden and characteristics of infection by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in clinical samples from intensive care unit (ICU) adults, and to identify predictors. This was a retrospective observational study at four medical-surgical ICUs. The case cohort comprised adults with documented isolation of an MDR-PA strain from a clinical specimen during ICU stay. Multivariate analysis was performed to identify predictors for MDR-PA infection. During the study period, 5667 patients were admitted to the ICU and P. aeruginosa was isolated in 504 (8.8%). MDR-PA was identified in 142 clinical samples from 104 patients (20.6%); 62 (43.6%) of these samples appeared to be true infections. One hundred and eighteen (83.1%) isolates were susceptible only to amikacin and colistin, and 13 (9.2%) were susceptible only to colistin. Overall, the MIC50 to meropenem was 16 μg/mL and the MIC90 was \\textgreater32 μg/mL, with 60.4% of respiratory samples being MIC \\textgreater32 μg/mL to meropenem. Independent predictors for MDR-PA infection were fever/hypothermia [odds ratio (OR) 9.09], recent antipseudomonal cephalosporin therapy (OR 6.31), vasopressors at infection onset (OR 4.40), and PIRO (predisposition, infection, response, and organ dysfunction) score \\textgreater2 (OR 2.06). This study provides novel information that may be of use for the clinical management of patients harboring MDR-PA and for the control of the spread of this organism.","number":"7","journal":"European Journal of Clinical Microbiology and Infectious Diseases","author":[{"propositions":[],"lastnames":["Borgatta"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Lagunes"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Imbiscuso"],"firstnames":["A.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Larrosa"],"firstnames":["M.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Lujàn"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Rello"],"firstnames":["J."],"suffixes":[]}],"month":"July","year":"2017","pmid":"28093651","note":"Publisher: Springer Verlag","pages":"1097–1104","bibtex":"@article{borgatta_infections_2017,\n\ttitle = {Infections in intensive care unit adult patients harboring multidrug-resistant {Pseudomonas} aeruginosa: implications for prevention and therapy},\n\tvolume = {36},\n\tissn = {14354373},\n\tdoi = {10.1007/s10096-016-2894-3},\n\tabstract = {The purpose of this paper was to report the burden and characteristics of infection by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in clinical samples from intensive care unit (ICU) adults, and to identify predictors. This was a retrospective observational study at four medical-surgical ICUs. The case cohort comprised adults with documented isolation of an MDR-PA strain from a clinical specimen during ICU stay. Multivariate analysis was performed to identify predictors for MDR-PA infection. During the study period, 5667 patients were admitted to the ICU and P. aeruginosa was isolated in 504 (8.8\\%). MDR-PA was identified in 142 clinical samples from 104 patients (20.6\\%); 62 (43.6\\%) of these samples appeared to be true infections. One hundred and eighteen (83.1\\%) isolates were susceptible only to amikacin and colistin, and 13 (9.2\\%) were susceptible only to colistin. Overall, the MIC50 to meropenem was 16 μg/mL and the MIC90 was {\\textgreater}32 μg/mL, with 60.4\\% of respiratory samples being MIC {\\textgreater}32 μg/mL to meropenem. Independent predictors for MDR-PA infection were fever/hypothermia [odds ratio (OR) 9.09], recent antipseudomonal cephalosporin therapy (OR 6.31), vasopressors at infection onset (OR 4.40), and PIRO (predisposition, infection, response, and organ dysfunction) score {\\textgreater}2 (OR 2.06). This study provides novel information that may be of use for the clinical management of patients harboring MDR-PA and for the control of the spread of this organism.},\n\tnumber = {7},\n\tjournal = {European Journal of Clinical Microbiology and Infectious Diseases},\n\tauthor = {Borgatta, B. and Lagunes, L. and Imbiscuso, A. T. and Larrosa, M. N. and Lujàn, M. and Rello, J.},\n\tmonth = jul,\n\tyear = {2017},\n\tpmid = {28093651},\n\tnote = {Publisher: Springer Verlag},\n\tpages = {1097--1104},\n}\n\n\n\n","author_short":["Borgatta, B.","Lagunes, L.","Imbiscuso, A. T.","Larrosa, M. N.","Lujàn, M.","Rello, J."],"key":"borgatta_infections_2017-1","id":"borgatta_infections_2017-1","bibbaseid":"borgatta-lagunes-imbiscuso-larrosa-lujn-rello-infectionsinintensivecareunitadultpatientsharboringmultidrugresistantpseudomonasaeruginosaimplicationsforpreventionandtherapy-2017","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/FRGBergamini","dataSources":["o2mL7kG99iAQPpNRJ"],"keywords":[],"search_terms":["infections","intensive","care","unit","adult","patients","harboring","multidrug","resistant","pseudomonas","aeruginosa","implications","prevention","therapy","borgatta","lagunes","imbiscuso","larrosa","lujàn","rello"],"title":"Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy","year":2017}