@article{Borodinsky2004,
	title = {Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.},
	volume = {429},
	issn = {1476-4687},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15175743},
	doi = {10.1038/nature02518},
	abstract = {Neurotransmitters are essential for interneuronal signalling, and the specification of appropriate transmitters in differentiating neurons has been related to intrinsic neuronal identity and to extrinsic signalling proteins. Here we show that altering the distinct patterns of Ca2+ spike activity spontaneously generated by different classes of embryonic spinal neurons in vivo changes the transmitter that neurons express without affecting the expression of markers of cell identity. Regulation seems to be homeostatic: suppression of activity leads to an increased number of neurons expressing excitatory transmitters and a decreased number of neurons expressing inhibitory transmitters; the reverse occurs when activity is enhanced. The imposition of specific spike frequencies in vitro does not affect labels of cell identity but again specifies the expression of transmitters that are inappropriate for the markers they express, during an early critical period. The results identify a new role of patterned activity in development of the central nervous system.},
	number = {6991},
	journal = {Nature},
	author = {Borodinsky, Laura N and Root, Cory M and Cronin, Julia a and Sann, Sharon B and Gu, Xiaonan and Spitzer, Nicholas C},
	month = jun,
	year = {2004},
	pmid = {15175743},
	keywords = {Action Potentials, Action Potentials: physiology, Animals, Calcium, Calcium Signaling, Calcium: metabolism, Cell Differentiation, Cells, Cultured, Gene Expression Regulation, Homeostasis, Humans, Inwardly Rectifying, Inwardly Rectifying: genetics, Inwardly Rectifying: metabolis, Neurons, Neurons: cytology, Neurons: metabolism, Neurons: physiology, Neurons: secretion, Neurotransmitter Agents, Neurotransmitter Agents: metabolism, Neurotransmitter Agents: secretion, Organ Specificity, Phenotype, Potassium Channels, Rats, Sodium Channels, Sodium Channels: genetics, Sodium Channels: metabolism, Spinal Cord, Spinal Cord: cytology, Spinal Cord: embryology, Spinal Cord: metabolism, Xenopus laevis},
	pages = {523--30},
}

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Here we show that altering the distinct patterns of Ca2+ spike activity spontaneously generated by different classes of embryonic spinal neurons in vivo changes the transmitter that neurons express without affecting the expression of markers of cell identity. Regulation seems to be homeostatic: suppression of activity leads to an increased number of neurons expressing excitatory transmitters and a decreased number of neurons expressing inhibitory transmitters; the reverse occurs when activity is enhanced. The imposition of specific spike frequencies in vitro does not affect labels of cell identity but again specifies the expression of transmitters that are inappropriate for the markers they express, during an early critical period. 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