Rule-based modelling and simulation of drug-administration policies. Bortolussi, L., Krüger, T., Lehr, T., & Wolf, V. In Proceedings of the Symposium on Modeling and Simulation in Medicine, pages 53-60, 2015. ![Rule-based modelling and simulation of drug-administration policies [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex We consider rule-based models extended with timedependent reaction rates, a suitable formalism to describe the effect of drug administration on biochemical systems. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space of such models. Furthermore, we investigate a model of drug administration in the context of a plaque-formation process of Alzheimer’s disease, a polymerization process best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying reaction network. Furthermore, time-dependent rates are needed to model the effect of drugs. We apply the simulation algorithm to study the efficacy of different drug administration policies.
@inproceedings{
title = {Rule-based modelling and simulation of drug-administration policies},
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abstract = {We consider rule-based models extended with timedependent reaction rates, a suitable formalism to describe the effect of drug administration on biochemical systems. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space of such models. Furthermore, we investigate a model of drug administration in the context of a plaque-formation process of Alzheimer’s disease, a polymerization process best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying reaction network. Furthermore, time-dependent rates are needed to model the effect of drugs. We apply the simulation algorithm to study the efficacy of different drug administration policies.},
bibtype = {inproceedings},
author = {Bortolussi, Luca and Krüger, Thilo and Lehr, Thorsten and Wolf, Verena},
booktitle = {Proceedings of the Symposium on Modeling and Simulation in Medicine}
}
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