@article{Boussaty2020,
  abstract = {This is the first genome-wide association study with the Hybrid Mouse Diversity Panel (HDMP) to define the genetic landscape of the variation in the suprathreshold wave 1 amplitude of the auditory brainstem response (ABR) both pre- and post-noise exposure. This measure is correlated with the density of the auditory neurons (AN) and/or the compliment of synaptic ribbons within the inner hair cells of the mouse cochlea. We analyzed suprathreshold ABR for 635 mice from 102 HMDP strains pre- and post-noise exposure (108 dB 10 kHz octave band noise exposure for 2 h) using auditory brainstem response (ABR) wave 1 suprathreshold amplitudes as part of a large survey (Myint et al., Hear Res 332:113–120, 2016). Genome-wide significance levels for pre- and post-exposure wave 1 amplitude across the HMDP were performed using FaST-LMM. Synaptic ribbon counts (Ctbp2 and mGluR2) were analyzed for the extreme strains within the HMDP. ABR wave 1 amplitude varied across all strains of the HMDP with differences ranging between 2.42 and 3.82-fold pre-exposure and between 2.43 and 7.5-fold post-exposure with several tone burst stimuli (4 kHz, 8 kHz, 12 kHz, 16 kHz, 24 kHz, and 32 kHz). Immunolabeling of paired synaptic ribbons and glutamate receptors of strains with the highest and lowest wave 1 values pre- and post-exposure revealed significant differences in functional synaptic ribbon counts. Genome-wide association analysis identified genome-wide significant threshold associations on chromosome 3 (24 kHz; JAX00105429; p < 1.12E-06) and chromosome 16 (16 kHz; JAX00424604; p < 9.02E-07) prior to noise exposure and significant associations on chromosomes 2 (32 kHz; JAX00497967; p < 3.68E-08) and 13 (8 kHz; JAX00049416; 1.07E-06) after noise exposure. In order to prioritize candidate genes, we generated cis-eQTLs from microarray profiling of RNA isolated from whole cochleae in 64 of the tested strains.},
  author = {Boussaty, Ely Cheikh and Gillard, Danielle and Lavinsky, Joel and Salehi, Pezhman and Wang, Juemei and Mendon{\c{c}}a, Aline and Allayee, Hooman and Manor, Uri and Friedman, Rick Adam},
  doi = {10.1007/s10162-020-00762-3},
  issn = {1438-7573},
  journal = {Journal of the Association for Research in Otolaryngology},
  number = {4},
  pages = {323--336},
  title = {{The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response}},
  url = {https://doi.org/10.1007/s10162-020-00762-3},
  volume = {21},
  year = {2020}
}

{"_id":"LEYDLbLFGjubZGCkc","bibbaseid":"boussaty-gillard-lavinsky-salehi-wang-mendona-allayee-manor-etal-thegeneticsofvariationofthewave1amplitudeofthemouseauditorybrainstemresponse-2020","author_short":["Boussaty, E. C.","Gillard, D.","Lavinsky, J.","Salehi, P.","Wang, J.","Mendonça, A.","Allayee, H.","Manor, U.","Friedman, R. A."],"bibdata":{"bibtype":"article","type":"article","abstract":"This is the first genome-wide association study with the Hybrid Mouse Diversity Panel (HDMP) to define the genetic landscape of the variation in the suprathreshold wave 1 amplitude of the auditory brainstem response (ABR) both pre- and post-noise exposure. This measure is correlated with the density of the auditory neurons (AN) and/or the compliment of synaptic ribbons within the inner hair cells of the mouse cochlea. We analyzed suprathreshold ABR for 635 mice from 102 HMDP strains pre- and post-noise exposure (108 dB 10 kHz octave band noise exposure for 2 h) using auditory brainstem response (ABR) wave 1 suprathreshold amplitudes as part of a large survey (Myint et al., Hear Res 332:113–120, 2016). Genome-wide significance levels for pre- and post-exposure wave 1 amplitude across the HMDP were performed using FaST-LMM. Synaptic ribbon counts (Ctbp2 and mGluR2) were analyzed for the extreme strains within the HMDP. ABR wave 1 amplitude varied across all strains of the HMDP with differences ranging between 2.42 and 3.82-fold pre-exposure and between 2.43 and 7.5-fold post-exposure with several tone burst stimuli (4 kHz, 8 kHz, 12 kHz, 16 kHz, 24 kHz, and 32 kHz). Immunolabeling of paired synaptic ribbons and glutamate receptors of strains with the highest and lowest wave 1 values pre- and post-exposure revealed significant differences in functional synaptic ribbon counts. Genome-wide association analysis identified genome-wide significant threshold associations on chromosome 3 (24 kHz; JAX00105429; p < 1.12E-06) and chromosome 16 (16 kHz; JAX00424604; p < 9.02E-07) prior to noise exposure and significant associations on chromosomes 2 (32 kHz; JAX00497967; p < 3.68E-08) and 13 (8 kHz; JAX00049416; 1.07E-06) after noise exposure. In order to prioritize candidate genes, we generated cis-eQTLs from microarray profiling of RNA isolated from whole cochleae in 64 of the tested strains.","author":[{"propositions":[],"lastnames":["Boussaty"],"firstnames":["Ely","Cheikh"],"suffixes":[]},{"propositions":[],"lastnames":["Gillard"],"firstnames":["Danielle"],"suffixes":[]},{"propositions":[],"lastnames":["Lavinsky"],"firstnames":["Joel"],"suffixes":[]},{"propositions":[],"lastnames":["Salehi"],"firstnames":["Pezhman"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Juemei"],"suffixes":[]},{"propositions":[],"lastnames":["Mendonça"],"firstnames":["Aline"],"suffixes":[]},{"propositions":[],"lastnames":["Allayee"],"firstnames":["Hooman"],"suffixes":[]},{"propositions":[],"lastnames":["Manor"],"firstnames":["Uri"],"suffixes":[]},{"propositions":[],"lastnames":["Friedman"],"firstnames":["Rick","Adam"],"suffixes":[]}],"doi":"10.1007/s10162-020-00762-3","issn":"1438-7573","journal":"Journal of the Association for Research in Otolaryngology","number":"4","pages":"323–336","title":"The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response","url":"https://doi.org/10.1007/s10162-020-00762-3","volume":"21","year":"2020","bibtex":"@article{Boussaty2020,\r\n abstract = {This is the first genome-wide association study with the Hybrid Mouse Diversity Panel (HDMP) to define the genetic landscape of the variation in the suprathreshold wave 1 amplitude of the auditory brainstem response (ABR) both pre- and post-noise exposure. This measure is correlated with the density of the auditory neurons (AN) and/or the compliment of synaptic ribbons within the inner hair cells of the mouse cochlea. We analyzed suprathreshold ABR for 635 mice from 102 HMDP strains pre- and post-noise exposure (108 dB 10 kHz octave band noise exposure for 2 h) using auditory brainstem response (ABR) wave 1 suprathreshold amplitudes as part of a large survey (Myint et al., Hear Res 332:113–120, 2016). Genome-wide significance levels for pre- and post-exposure wave 1 amplitude across the HMDP were performed using FaST-LMM. Synaptic ribbon counts (Ctbp2 and mGluR2) were analyzed for the extreme strains within the HMDP. ABR wave 1 amplitude varied across all strains of the HMDP with differences ranging between 2.42 and 3.82-fold pre-exposure and between 2.43 and 7.5-fold post-exposure with several tone burst stimuli (4 kHz, 8 kHz, 12 kHz, 16 kHz, 24 kHz, and 32 kHz). Immunolabeling of paired synaptic ribbons and glutamate receptors of strains with the highest and lowest wave 1 values pre- and post-exposure revealed significant differences in functional synaptic ribbon counts. Genome-wide association analysis identified genome-wide significant threshold associations on chromosome 3 (24 kHz; JAX00105429; p < 1.12E-06) and chromosome 16 (16 kHz; JAX00424604; p < 9.02E-07) prior to noise exposure and significant associations on chromosomes 2 (32 kHz; JAX00497967; p < 3.68E-08) and 13 (8 kHz; JAX00049416; 1.07E-06) after noise exposure. In order to prioritize candidate genes, we generated cis-eQTLs from microarray profiling of RNA isolated from whole cochleae in 64 of the tested strains.},\r\n author = {Boussaty, Ely Cheikh and Gillard, Danielle and Lavinsky, Joel and Salehi, Pezhman and Wang, Juemei and Mendon{\\c{c}}a, Aline and Allayee, Hooman and Manor, Uri and Friedman, Rick Adam},\r\n doi = {10.1007/s10162-020-00762-3},\r\n issn = {1438-7573},\r\n journal = {Journal of the Association for Research in Otolaryngology},\r\n number = {4},\r\n pages = {323--336},\r\n title = {{The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response}},\r\n url = {https://doi.org/10.1007/s10162-020-00762-3},\r\n volume = {21},\r\n year = {2020}\r\n}\r\n\r\n","author_short":["Boussaty, E. C.","Gillard, D.","Lavinsky, J.","Salehi, P.","Wang, J.","Mendonça, A.","Allayee, H.","Manor, U.","Friedman, R. A."],"key":"Boussaty2020","id":"Boussaty2020","bibbaseid":"boussaty-gillard-lavinsky-salehi-wang-mendona-allayee-manor-etal-thegeneticsofvariationofthewave1amplitudeofthemouseauditorybrainstemresponse-2020","role":"author","urls":{"Paper":"https://doi.org/10.1007/s10162-020-00762-3"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://github.com/salkmanorlab/manor_publications/raw/main/manorlab_pubs.bib","dataSources":["edXsq84pNeYoA6wo6","dr3nCm3wyZkR7nFZf"],"keywords":[],"search_terms":["genetics","variation","wave","amplitude","mouse","auditory","brainstem","response","boussaty","gillard","lavinsky","salehi","wang","mendonça","allayee","manor","friedman"],"title":"The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response","year":2020}