HDX-Viewer: interactive 3D visualization of hydrogen–deuterium exchange data. Bouyssié, D., Lesne, J., Locard-Paulet, M., Albigot, R., Burlet-Schiltz, O., & Marcoux, J. Bioinformatics, 35(24):5331–5333, December, 2019.
Paper doi abstract bibtex Abstract Summary With the advent of fully automated sample preparation robots for Hydrogen–Deuterium eXchange coupled to Mass Spectrometry (HDX-MS), this method has become paramount for ligand binding or epitope mapping screening, both in academic research and biopharmaceutical industries. However, bridging the gap between commercial HDX-MS software (for raw data interpretation) and molecular viewers (to map experiment results onto a 3D structure for biological interpretation) remains laborious and requires simple but sometimes limiting coding skills. We solved this bottleneck by developing HDX-Viewer, an open-source web-based application that facilitates and quickens HDX-MS data analysis. This user-friendly application automatically incorporates HDX-MS data from a custom template or commercial HDX-MS software in PDB files, and uploads them to an online 3D molecular viewer, thereby facilitating their visualization and biological interpretation. Availability and implementation The HDX-Viewer web application is released under the CeCILL (http://www.cecill.info) and GNU LGPL licenses and can be found at https://masstools.ipbs.fr/hdx-viewer. The source code is available at https://github.com/david-bouyssie/hdx-viewer.
@article{bouyssie_hdx-viewer_2019,
title = {{HDX}-{Viewer}: interactive {3D} visualization of hydrogen–deuterium exchange data},
volume = {35},
issn = {1367-4803, 1460-2059},
shorttitle = {{HDX}-{Viewer}},
url = {https://academic.oup.com/bioinformatics/article/35/24/5331/5530164},
doi = {10.1093/bioinformatics/btz550},
abstract = {Abstract
Summary
With the advent of fully automated sample preparation robots for Hydrogen–Deuterium eXchange coupled to Mass Spectrometry (HDX-MS), this method has become paramount for ligand binding or epitope mapping screening, both in academic research and biopharmaceutical industries. However, bridging the gap between commercial HDX-MS software (for raw data interpretation) and molecular viewers (to map experiment results onto a 3D structure for biological interpretation) remains laborious and requires simple but sometimes limiting coding skills. We solved this bottleneck by developing HDX-Viewer, an open-source web-based application that facilitates and quickens HDX-MS data analysis. This user-friendly application automatically incorporates HDX-MS data from a custom template or commercial HDX-MS software in PDB files, and uploads them to an online 3D molecular viewer, thereby facilitating their visualization and biological interpretation.
Availability and implementation
The HDX-Viewer web application is released under the CeCILL (http://www.cecill.info) and GNU LGPL licenses and can be found at https://masstools.ipbs.fr/hdx-viewer. The source code is available at https://github.com/david-bouyssie/hdx-viewer.},
language = {en},
number = {24},
urldate = {2022-06-08},
journal = {Bioinformatics},
author = {Bouyssié, David and Lesne, Jean and Locard-Paulet, Marie and Albigot, Renaud and Burlet-Schiltz, Odile and Marcoux, Julien},
editor = {Elofsson, Arne},
month = dec,
year = {2019},
pages = {5331--5333},
}
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