@article{RN173,
   author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Aetiology of cognitive impairment in children with frontal lobe epilepsy},
   journal = {Acta Neurol Scand},
   volume = {131},
   number = {1},
   pages = {17-29},
   note = {Braakman, H M H
Vaessen, M J
Jansen, J F A
Debeij-van Hall, M H J A
de Louw, A
Hofman, P A M
Vles, J S H
Aldenkamp, A P
Backes, W H
eng
Research Support, Non-U.S. Gov't
Denmark
2014/09/12 06:00
Acta Neurol Scand. 2015 Jan;131(1):17-29. doi: 10.1111/ane.12283. Epub 2014 Sep 10.},
   abstract = {OBJECTIVES: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its aetiology is unknown. MRI scans often reveal no structural brain abnormalities that could explain the cognitive impairment. This does not exclude more subtle morphological abnormalities that can only be detected by automated morphometric techniques. AIMS: With these techniques, we investigate the relationship between cortical brain morphology and cognitive functioning in a cohort of children with FLE and healthy controls. MATERIALS AND METHODS: Thirty-four children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural brain MRI. Patients were grouped as cognitively impaired or unimpaired. Intracranial volume, white matter volume, lobular cortical volume, cortical thickness and volumes of cortex structures were compared between patients and controls, and potential correlations with cognitive status were determined. RESULTS: The group of cognitively impaired children with FLE had significantly smaller left temporal cortex volumes, specifically middle temporal grey matter volume and entorhinal cortex thickness. In addition, cognitively impaired children with FLE had smaller volumes of structures in the left and right frontal cortex, right temporal cortex and the left subcortical area. CONCLUSION: Cognitively impaired children with FLE have smaller volumes of various cortex structures within the frontal lobes and in extra-frontal regions, most notably temporal cortex volumes. These findings might well explain the broad scale of cognitive domains affected in children with FLE complicated by cognitive impairment and highlight that FLE impacts on areas beyond the frontal lobe.},
   keywords = {Adolescent
Brain/*pathology
Child
Cognition Disorders/*etiology/*pathology
Epilepsy, Frontal Lobe/*complications/*pathology
Female
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Mri
all epilepsy/seizures
all paediatric
neuropsychological assessment
volumetric MRI},
   ISSN = {1600-0404 (Electronic)
0001-6314 (Linking)},
   DOI = {10.1111/ane.12283},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25208759
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12283},
   year = {2015},
   type = {Journal Article}
}

{"_id":"sinDt6upmwPiFt6xt","bibbaseid":"braakman-vaessen-jansen-debeijvanhall-delouw-hofman-vles-aldenkamp-etal-aetiologyofcognitiveimpairmentinchildrenwithfrontallobeepilepsy-2015","downloads":0,"creationDate":"2017-09-02T18:10:13.481Z","title":"Aetiology of cognitive impairment in children with frontal lobe epilepsy","author_short":["Braakman, H. M.","Vaessen, M. J.","Jansen, J. F.","Debeij-van Hall, M. H.","de Louw, A.","Hofman, P. A.","Vles, J. S.","Aldenkamp, A. P.","Backes, W. H."],"year":2015,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Braakman"],"firstnames":["H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Vaessen"],"firstnames":["M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Debeij-van","Hall"],"firstnames":["M.","H."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Vles"],"firstnames":["J.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Aetiology of cognitive impairment in children with frontal lobe epilepsy","journal":"Acta Neurol Scand","volume":"131","number":"1","pages":"17-29","note":"Braakman, H M H Vaessen, M J Jansen, J F A Debeij-van Hall, M H J A de Louw, A Hofman, P A M Vles, J S H Aldenkamp, A P Backes, W H eng Research Support, Non-U.S. Gov't Denmark 2014/09/12 06:00 Acta Neurol Scand. 2015 Jan;131(1):17-29. doi: 10.1111/ane.12283. Epub 2014 Sep 10.","abstract":"OBJECTIVES: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its aetiology is unknown. MRI scans often reveal no structural brain abnormalities that could explain the cognitive impairment. This does not exclude more subtle morphological abnormalities that can only be detected by automated morphometric techniques. AIMS: With these techniques, we investigate the relationship between cortical brain morphology and cognitive functioning in a cohort of children with FLE and healthy controls. MATERIALS AND METHODS: Thirty-four children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural brain MRI. Patients were grouped as cognitively impaired or unimpaired. Intracranial volume, white matter volume, lobular cortical volume, cortical thickness and volumes of cortex structures were compared between patients and controls, and potential correlations with cognitive status were determined. RESULTS: The group of cognitively impaired children with FLE had significantly smaller left temporal cortex volumes, specifically middle temporal grey matter volume and entorhinal cortex thickness. In addition, cognitively impaired children with FLE had smaller volumes of structures in the left and right frontal cortex, right temporal cortex and the left subcortical area. CONCLUSION: Cognitively impaired children with FLE have smaller volumes of various cortex structures within the frontal lobes and in extra-frontal regions, most notably temporal cortex volumes. These findings might well explain the broad scale of cognitive domains affected in children with FLE complicated by cognitive impairment and highlight that FLE impacts on areas beyond the frontal lobe.","keywords":"Adolescent Brain/*pathology Child Cognition Disorders/*etiology/*pathology Epilepsy, Frontal Lobe/*complications/*pathology Female Humans Magnetic Resonance Imaging Male Neuropsychological Tests Mri all epilepsy/seizures all paediatric neuropsychological assessment volumetric MRI","issn":"1600-0404 (Electronic) 0001-6314 (Linking)","doi":"10.1111/ane.12283","url":"http://www.ncbi.nlm.nih.gov/pubmed/25208759 https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12283","year":"2015","bibtex":"@article{RN173,\n author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Aetiology of cognitive impairment in children with frontal lobe epilepsy},\n journal = {Acta Neurol Scand},\n volume = {131},\n number = {1},\n pages = {17-29},\n note = {Braakman, H M H\nVaessen, M J\nJansen, J F A\nDebeij-van Hall, M H J A\nde Louw, A\nHofman, P A M\nVles, J S H\nAldenkamp, A P\nBackes, W H\neng\nResearch Support, Non-U.S. Gov't\nDenmark\n2014/09/12 06:00\nActa Neurol Scand. 2015 Jan;131(1):17-29. doi: 10.1111/ane.12283. Epub 2014 Sep 10.},\n abstract = {OBJECTIVES: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its aetiology is unknown. MRI scans often reveal no structural brain abnormalities that could explain the cognitive impairment. This does not exclude more subtle morphological abnormalities that can only be detected by automated morphometric techniques. AIMS: With these techniques, we investigate the relationship between cortical brain morphology and cognitive functioning in a cohort of children with FLE and healthy controls. MATERIALS AND METHODS: Thirty-four children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural brain MRI. Patients were grouped as cognitively impaired or unimpaired. Intracranial volume, white matter volume, lobular cortical volume, cortical thickness and volumes of cortex structures were compared between patients and controls, and potential correlations with cognitive status were determined. RESULTS: The group of cognitively impaired children with FLE had significantly smaller left temporal cortex volumes, specifically middle temporal grey matter volume and entorhinal cortex thickness. In addition, cognitively impaired children with FLE had smaller volumes of structures in the left and right frontal cortex, right temporal cortex and the left subcortical area. CONCLUSION: Cognitively impaired children with FLE have smaller volumes of various cortex structures within the frontal lobes and in extra-frontal regions, most notably temporal cortex volumes. These findings might well explain the broad scale of cognitive domains affected in children with FLE complicated by cognitive impairment and highlight that FLE impacts on areas beyond the frontal lobe.},\n keywords = {Adolescent\nBrain/*pathology\nChild\nCognition Disorders/*etiology/*pathology\nEpilepsy, Frontal Lobe/*complications/*pathology\nFemale\nHumans\nMagnetic Resonance Imaging\nMale\nNeuropsychological Tests\nMri\nall epilepsy/seizures\nall paediatric\nneuropsychological assessment\nvolumetric MRI},\n ISSN = {1600-0404 (Electronic)\n0001-6314 (Linking)},\n DOI = {10.1111/ane.12283},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/25208759\nhttps://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12283},\n year = {2015},\n type = {Journal Article}\n}\n\n","author_short":["Braakman, H. M.","Vaessen, M. J.","Jansen, J. F.","Debeij-van Hall, M. H.","de Louw, A.","Hofman, P. A.","Vles, J. S.","Aldenkamp, A. P.","Backes, W. 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