@article{RN160,
   author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy},
   journal = {Epilepsia},
   volume = {54},
   number = {3},
   pages = {446-54},
   note = {Braakman, Hilde M H
Vaessen, Maarten J
Jansen, Jacobus F A
Debeij-van Hall, Mariette H J A
de Louw, Anton
Hofman, Paul A M
Vles, Johan S H
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2012/12/21 06:00
Epilepsia. 2013 Mar;54(3):446-54. doi: 10.1111/epi.12044. Epub 2012 Dec 17.},
   abstract = {PURPOSE: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its etiology is unknown. With functional magnetic resonance imaging (fMRI), we have explored the relationship between brain activation, functional connectivity, and cognitive functioning in a cohort of pediatric patients with FLE and healthy controls. METHODS: Thirty-two children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural and functional brain MRI. We investigated to which extent brain regions activated in response to a working memory task and assessed functional connectivity between distant brain regions. Data of patients were compared to controls, and patients were grouped as cognitively impaired or unimpaired. KEY FINDINGS: Children with FLE showed a global decrease in functional brain connectivity compared to healthy controls, whereas brain activation patterns in children with FLE remained relatively intact. Children with FLE complicated by cognitive impairment typically showed a decrease in frontal lobe connectivity. This decreased frontal lobe connectivity comprised both connections within the frontal lobe as well as connections from the frontal lobe to the parietal lobe, temporal lobe, cerebellum, and basal ganglia. SIGNIFICANCE: Decreased functional frontal lobe connectivity is associated with cognitive impairment in pediatric FLE. The importance of impairment of functional integrity within the frontal lobe network, as well as its connections to distant areas, provides new insights in the etiology of the broad-range cognitive impairments in children with FLE.},
   keywords = {Adolescent
Child
Cognition Disorders/*epidemiology/*physiopathology/psychology
Cohort Studies
Epilepsy, Frontal Lobe/*epidemiology/*physiopathology/psychology
Female
Frontal Lobe/*physiology
Humans
Male
Nerve Net/*physiology
Neural Pathways/physiology
Photic Stimulation/methods
Psychomotor Performance/physiology
Registries},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/epi.12044},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23253092
https://onlinelibrary.wiley.com/doi/full/10.1111/epi.12044},
   year = {2013},
   type = {Journal Article}
}

{"_id":"qNapwW9Tr8qBvtuCC","bibbaseid":"braakman-vaessen-jansen-debeijvanhall-delouw-hofman-vles-aldenkamp-etal-frontallobeconnectivityandcognitiveimpairmentinpediatricfrontallobeepilepsy-2013","downloads":0,"creationDate":"2017-09-02T18:10:13.515Z","title":"Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy","author_short":["Braakman, H. M.","Vaessen, M. J.","Jansen, J. F.","Debeij-van Hall, M. H.","de Louw, A.","Hofman, P. A.","Vles, J. S.","Aldenkamp, A. P.","Backes, W. H."],"year":2013,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Braakman"],"firstnames":["H.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Vaessen"],"firstnames":["M.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Debeij-van","Hall"],"firstnames":["M.","H."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Vles"],"firstnames":["J.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy","journal":"Epilepsia","volume":"54","number":"3","pages":"446-54","note":"Braakman, Hilde M H Vaessen, Maarten J Jansen, Jacobus F A Debeij-van Hall, Mariette H J A de Louw, Anton Hofman, Paul A M Vles, Johan S H Aldenkamp, Albert P Backes, Walter H eng Research Support, Non-U.S. Gov't 2012/12/21 06:00 Epilepsia. 2013 Mar;54(3):446-54. doi: 10.1111/epi.12044. Epub 2012 Dec 17.","abstract":"PURPOSE: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its etiology is unknown. With functional magnetic resonance imaging (fMRI), we have explored the relationship between brain activation, functional connectivity, and cognitive functioning in a cohort of pediatric patients with FLE and healthy controls. METHODS: Thirty-two children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural and functional brain MRI. We investigated to which extent brain regions activated in response to a working memory task and assessed functional connectivity between distant brain regions. Data of patients were compared to controls, and patients were grouped as cognitively impaired or unimpaired. KEY FINDINGS: Children with FLE showed a global decrease in functional brain connectivity compared to healthy controls, whereas brain activation patterns in children with FLE remained relatively intact. Children with FLE complicated by cognitive impairment typically showed a decrease in frontal lobe connectivity. This decreased frontal lobe connectivity comprised both connections within the frontal lobe as well as connections from the frontal lobe to the parietal lobe, temporal lobe, cerebellum, and basal ganglia. SIGNIFICANCE: Decreased functional frontal lobe connectivity is associated with cognitive impairment in pediatric FLE. The importance of impairment of functional integrity within the frontal lobe network, as well as its connections to distant areas, provides new insights in the etiology of the broad-range cognitive impairments in children with FLE.","keywords":"Adolescent Child Cognition Disorders/*epidemiology/*physiopathology/psychology Cohort Studies Epilepsy, Frontal Lobe/*epidemiology/*physiopathology/psychology Female Frontal Lobe/*physiology Humans Male Nerve Net/*physiology Neural Pathways/physiology Photic Stimulation/methods Psychomotor Performance/physiology Registries","issn":"1528-1167 (Electronic) 0013-9580 (Linking)","doi":"10.1111/epi.12044","url":"http://www.ncbi.nlm.nih.gov/pubmed/23253092 https://onlinelibrary.wiley.com/doi/full/10.1111/epi.12044","year":"2013","bibtex":"@article{RN160,\n author = {Braakman, H. M. and Vaessen, M. J. and Jansen, J. F. and Debeij-van Hall, M. H. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy},\n journal = {Epilepsia},\n volume = {54},\n number = {3},\n pages = {446-54},\n note = {Braakman, Hilde M H\nVaessen, Maarten J\nJansen, Jacobus F A\nDebeij-van Hall, Mariette H J A\nde Louw, Anton\nHofman, Paul A M\nVles, Johan S H\nAldenkamp, Albert P\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\n2012/12/21 06:00\nEpilepsia. 2013 Mar;54(3):446-54. doi: 10.1111/epi.12044. Epub 2012 Dec 17.},\n abstract = {PURPOSE: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its etiology is unknown. With functional magnetic resonance imaging (fMRI), we have explored the relationship between brain activation, functional connectivity, and cognitive functioning in a cohort of pediatric patients with FLE and healthy controls. METHODS: Thirty-two children aged 8-13 years with FLE of unknown cause and 41 healthy age-matched controls underwent neuropsychological assessment and structural and functional brain MRI. We investigated to which extent brain regions activated in response to a working memory task and assessed functional connectivity between distant brain regions. Data of patients were compared to controls, and patients were grouped as cognitively impaired or unimpaired. KEY FINDINGS: Children with FLE showed a global decrease in functional brain connectivity compared to healthy controls, whereas brain activation patterns in children with FLE remained relatively intact. Children with FLE complicated by cognitive impairment typically showed a decrease in frontal lobe connectivity. This decreased frontal lobe connectivity comprised both connections within the frontal lobe as well as connections from the frontal lobe to the parietal lobe, temporal lobe, cerebellum, and basal ganglia. 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