In vitro fertilization and childhood retinoblastoma. Bradbury, B. D. & Jick, H. British Journal of Clinical Pharmacology, 58(2):209--211, August, 2004. doi abstract bibtex AIMS: To estimate the frequency of childhood retinoblastoma among children conceived by in vitro fertilization (IVF). METHODS: Using the United Kingdom-based General Practice Research Database (GPRD), we identified all live births, cases of retinoblastoma and IVF procedures occurring between January 1989 and December 2001. RESULTS: We identified 0 cases of retinoblastoma among 176 children conceived by IVF (Risk = 0/176, one-sided 97.5% CI 0, 0.02) and 24 cases of retinoblastoma diagnosed before age 5 years among 358,094 children not conceived by IVF (6.7 cases per 100,000 births [95% CI 4.5, 10]). CONCLUSIONS: These data provide some reassurance that children born as a result of IVF are not at markedly increased risk of retinoblastoma.
@article{bradbury_vitro_2004,
title = {In vitro fertilization and childhood retinoblastoma},
volume = {58},
issn = {0306-5251},
doi = {10.1111/j.1365-2125.2004.02109.x},
abstract = {AIMS: To estimate the frequency of childhood retinoblastoma among children conceived by in vitro fertilization (IVF).
METHODS: Using the United Kingdom-based General Practice Research Database (GPRD), we identified all live births, cases of retinoblastoma and IVF procedures occurring between January 1989 and December 2001.
RESULTS: We identified 0 cases of retinoblastoma among 176 children conceived by IVF (Risk = 0/176, one-sided 97.5\% CI 0, 0.02) and 24 cases of retinoblastoma diagnosed before age 5 years among 358,094 children not conceived by IVF (6.7 cases per 100,000 births [95\% CI 4.5, 10]).
CONCLUSIONS: These data provide some reassurance that children born as a result of IVF are not at markedly increased risk of retinoblastoma.},
language = {eng},
number = {2},
journal = {British Journal of Clinical Pharmacology},
author = {Bradbury, Brian D. and Jick, Hershel},
month = aug,
year = {2004},
pmid = {15255804},
pmcid = {PMC1884583},
keywords = {Adult, Child, Female, Fertilization in Vitro, Great Britain, Humans, Male, Maternal Age, Retinal Neoplasms, Retinoblastoma, pregnancy},
pages = {209--211}
}
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