@article{RN352,
   author = {Brandt, Y. and Alers, R. J. and Canjels, L. P. W. and Jorissen, L. M. and Jansen, G. and Janssen, Ebnj and van Kuijk, S. and Went, T. M. and Koehn, D. and Gerretsen, S. C. and Jansen, J. and Backes, W. and Hurks, P. P. M. and van de Ven, V. and Kooi, M. E. and Spaanderman, M. E. A. and Ghossein-Doha, C.},
   title = {DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot study},
   journal = {BMJ Open},
   volume = {14},
   number = {3},
   pages = {e077534},
   note = {Brandt, Yentl
Alers, Robert-Jan
Canjels, Lisanne P W
Jorissen, Laura M
Jansen, Gwyneth
Janssen, Emma B N J
van Kuijk, Sander
Went, Tamara Michelle
Koehn, Dennis
Gerretsen, Suzanne C
Jansen, Jacobus
Backes, Walter
Hurks, Petra P M
van de Ven, Vincent
Kooi, M Eline
Spaanderman, Marc E A
Ghossein-Doha, Chahinda
eng
England
2024/03/06
BMJ Open. 2024 Mar 4;14(3):e077534. doi: 10.1136/bmjopen-2023-077534.},
   abstract = {INTRODUCTION: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between women after pre-eclampsia and women after normotensive gestation. We hypothesise that pre-eclampsia alters cerebral and myocardial microvascular functions, which in turn are related to diminished cognitive and cardiac performance. METHODS AND ANALYSIS: The cross-sectional 'DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia' (DECONNECT) pilot study includes women after pre-eclampsia and controls after normotensive pregnancy between 6 months and 20 years after gestation. We recruit women from the Queen of Hearts study, a study investigating subclinical heart failure after pre-eclampsia. Neuropsychological tests are employed to assess different cognitive domains, including attention, processing speed, and cognitive control. Cerebral images are recorded using a 7 Tesla MRI to assess blood-brain barrier integrity, perfusion, blood flow, functional and structural networks, and anatomical dimensions. Cardiac images are recorded using a 3 Tesla MRI to assess cardiac perfusion, strain, dimensions, mass, and degree of fibrosis. We assess the effect of a history of pre-eclampsia using multivariable regression analyses. ETHICS AND DISSEMINATION: This study is approved by the Ethics Committee of Maastricht University Medical Centre (METC azM/UM, NL47252.068.14). Knowledge dissemination will include scientific publications, presentations at conferences and public forums, and social media. TRIAL REGISTRATION NUMBER: NCT02347540.},
   keywords = {Cardiology
Cardiovascular imaging
Head & neck imaging
Maternal medicine
Neurology
Obstetrics},
   ISSN = {2044-6055 (Electronic)
2044-6055 (Linking)},
   DOI = {10.1136/bmjopen-2023-077534},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/38443087},
   year = {2024},
   type = {Journal Article}
}

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A.","Ghossein-Doha, C."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Brandt"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Alers"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Canjels"],"firstnames":["L.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Jorissen"],"firstnames":["L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Janssen"],"firstnames":["Ebnj"],"suffixes":[]},{"propositions":["van"],"lastnames":["Kuijk"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Went"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Koehn"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Gerretsen"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W."],"suffixes":[]},{"propositions":[],"lastnames":["Hurks"],"firstnames":["P.","P.","M."],"suffixes":[]},{"propositions":["van","de"],"lastnames":["Ven"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Kooi"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Spaanderman"],"firstnames":["M.","E.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Ghossein-Doha"],"firstnames":["C."],"suffixes":[]}],"title":"DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot study","journal":"BMJ Open","volume":"14","number":"3","pages":"e077534","note":"Brandt, Yentl Alers, Robert-Jan Canjels, Lisanne P W Jorissen, Laura M Jansen, Gwyneth Janssen, Emma B N J van Kuijk, Sander Went, Tamara Michelle Koehn, Dennis Gerretsen, Suzanne C Jansen, Jacobus Backes, Walter Hurks, Petra P M van de Ven, Vincent Kooi, M Eline Spaanderman, Marc E A Ghossein-Doha, Chahinda eng England 2024/03/06 BMJ Open. 2024 Mar 4;14(3):e077534. doi: 10.1136/bmjopen-2023-077534.","abstract":"INTRODUCTION: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between women after pre-eclampsia and women after normotensive gestation. We hypothesise that pre-eclampsia alters cerebral and myocardial microvascular functions, which in turn are related to diminished cognitive and cardiac performance. METHODS AND ANALYSIS: The cross-sectional 'DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia' (DECONNECT) pilot study includes women after pre-eclampsia and controls after normotensive pregnancy between 6 months and 20 years after gestation. We recruit women from the Queen of Hearts study, a study investigating subclinical heart failure after pre-eclampsia. Neuropsychological tests are employed to assess different cognitive domains, including attention, processing speed, and cognitive control. Cerebral images are recorded using a 7 Tesla MRI to assess blood-brain barrier integrity, perfusion, blood flow, functional and structural networks, and anatomical dimensions. Cardiac images are recorded using a 3 Tesla MRI to assess cardiac perfusion, strain, dimensions, mass, and degree of fibrosis. We assess the effect of a history of pre-eclampsia using multivariable regression analyses. ETHICS AND DISSEMINATION: This study is approved by the Ethics Committee of Maastricht University Medical Centre (METC azM/UM, NL47252.068.14). Knowledge dissemination will include scientific publications, presentations at conferences and public forums, and social media. TRIAL REGISTRATION NUMBER: NCT02347540.","keywords":"Cardiology Cardiovascular imaging Head & neck imaging Maternal medicine Neurology Obstetrics","issn":"2044-6055 (Electronic) 2044-6055 (Linking)","doi":"10.1136/bmjopen-2023-077534","url":"https://www.ncbi.nlm.nih.gov/pubmed/38443087","year":"2024","bibtex":"@article{RN352,\n author = {Brandt, Y. and Alers, R. J. and Canjels, L. P. W. and Jorissen, L. M. and Jansen, G. and Janssen, Ebnj and van Kuijk, S. and Went, T. M. and Koehn, D. and Gerretsen, S. C. and Jansen, J. and Backes, W. and Hurks, P. P. M. and van de Ven, V. and Kooi, M. E. and Spaanderman, M. E. A. and Ghossein-Doha, C.},\n title = {DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot study},\n journal = {BMJ Open},\n volume = {14},\n number = {3},\n pages = {e077534},\n note = {Brandt, Yentl\nAlers, Robert-Jan\nCanjels, Lisanne P W\nJorissen, Laura M\nJansen, Gwyneth\nJanssen, Emma B N J\nvan Kuijk, Sander\nWent, Tamara Michelle\nKoehn, Dennis\nGerretsen, Suzanne C\nJansen, Jacobus\nBackes, Walter\nHurks, Petra P M\nvan de Ven, Vincent\nKooi, M Eline\nSpaanderman, Marc E A\nGhossein-Doha, Chahinda\neng\nEngland\n2024/03/06\nBMJ Open. 2024 Mar 4;14(3):e077534. doi: 10.1136/bmjopen-2023-077534.},\n abstract = {INTRODUCTION: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between women after pre-eclampsia and women after normotensive gestation. We hypothesise that pre-eclampsia alters cerebral and myocardial microvascular functions, which in turn are related to diminished cognitive and cardiac performance. METHODS AND ANALYSIS: The cross-sectional 'DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia' (DECONNECT) pilot study includes women after pre-eclampsia and controls after normotensive pregnancy between 6 months and 20 years after gestation. We recruit women from the Queen of Hearts study, a study investigating subclinical heart failure after pre-eclampsia. Neuropsychological tests are employed to assess different cognitive domains, including attention, processing speed, and cognitive control. Cerebral images are recorded using a 7 Tesla MRI to assess blood-brain barrier integrity, perfusion, blood flow, functional and structural networks, and anatomical dimensions. Cardiac images are recorded using a 3 Tesla MRI to assess cardiac perfusion, strain, dimensions, mass, and degree of fibrosis. We assess the effect of a history of pre-eclampsia using multivariable regression analyses. ETHICS AND DISSEMINATION: This study is approved by the Ethics Committee of Maastricht University Medical Centre (METC azM/UM, NL47252.068.14). Knowledge dissemination will include scientific publications, presentations at conferences and public forums, and social media. 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