@article{brandt_control_2013,
	series = {Developmental plasticity and adaptation in plants},
	title = {Control of stem cell homeostasis via interlocking {microRNA} and {microProtein} feedback loops},
	volume = {130},
	issn = {0925-4773},
	url = {https://www.sciencedirect.com/science/article/pii/S0925477312000603},
	doi = {10.1016/j.mod.2012.06.007},
	abstract = {Stem cells in the shoot apex of plants produce cells required for the formation of new leaves. Adult leaves are composed of multiple tissue layers arranged along the dorso-ventral (adaxial/abaxial) axis. Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play an important role in the set-up of leaf polarity in plants. Loss of HD-ZIPIII function results in strongly misshapen leaves and in severe cases fosters the consumption of the apical stem cells, thus causing a growth arrest in mutant plants. HD-ZIPIII mRNA is under tight control by microRNAs 165/166. In addition to the microRNA-action a second layer of regulation is established by LITTLE ZIPPER (ZPR)-type microProteins, which can interact with HD-ZIPIII proteins, forming attenuated protein complexes. Here we show that REVOLUTA (REV, a member of the HD-ZIPIII family) directly regulates the expression of ARGONAUTE10 (AGO10), ZPR1 and ZPR3. Because AGO10 was shown to dampen microRNA165/6 function, REV establishes a positive feedback loop on its own activity. Since ZPR-type microProteins are known to reduce HD-ZIPIII protein activity, REV concomitantly establishes a negative feedback loop. We propose that the interconnection of these microRNA/microProtein feedback loops regulates polarity set-up and stem cell activity in plants.},
	language = {en},
	number = {1},
	urldate = {2022-11-30},
	journal = {Mechanisms of Development},
	author = {Brandt, Ronny and Xie, Yakun and Musielak, Thomas and Graeff, Moritz and Stierhof, York-Dieter and Huang, Hai and Liu, Chun-Ming and Wenkel, Stephan},
	month = jan,
	year = {2013},
	keywords = {AGO10, HD-ZIPIII transcription factors, LITTLE ZIPPER, Shoot apical meristem, microProteins, microRNAs},
	pages = {25--33},
}

{"_id":"wb3jHFyqs5r6KEqwc","bibbaseid":"brandt-xie-musielak-graeff-stierhof-huang-liu-wenkel-controlofstemcellhomeostasisviainterlockingmicrornaandmicroproteinfeedbackloops-2013","author_short":["Brandt, R.","Xie, Y.","Musielak, T.","Graeff, M.","Stierhof, Y.","Huang, H.","Liu, C.","Wenkel, S."],"bibdata":{"bibtype":"article","type":"article","series":"Developmental plasticity and adaptation in plants","title":"Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops","volume":"130","issn":"0925-4773","url":"https://www.sciencedirect.com/science/article/pii/S0925477312000603","doi":"10.1016/j.mod.2012.06.007","abstract":"Stem cells in the shoot apex of plants produce cells required for the formation of new leaves. Adult leaves are composed of multiple tissue layers arranged along the dorso-ventral (adaxial/abaxial) axis. Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play an important role in the set-up of leaf polarity in plants. Loss of HD-ZIPIII function results in strongly misshapen leaves and in severe cases fosters the consumption of the apical stem cells, thus causing a growth arrest in mutant plants. HD-ZIPIII mRNA is under tight control by microRNAs 165/166. In addition to the microRNA-action a second layer of regulation is established by LITTLE ZIPPER (ZPR)-type microProteins, which can interact with HD-ZIPIII proteins, forming attenuated protein complexes. Here we show that REVOLUTA (REV, a member of the HD-ZIPIII family) directly regulates the expression of ARGONAUTE10 (AGO10), ZPR1 and ZPR3. Because AGO10 was shown to dampen microRNA165/6 function, REV establishes a positive feedback loop on its own activity. Since ZPR-type microProteins are known to reduce HD-ZIPIII protein activity, REV concomitantly establishes a negative feedback loop. We propose that the interconnection of these microRNA/microProtein feedback loops regulates polarity set-up and stem cell activity in plants.","language":"en","number":"1","urldate":"2022-11-30","journal":"Mechanisms of Development","author":[{"propositions":[],"lastnames":["Brandt"],"firstnames":["Ronny"],"suffixes":[]},{"propositions":[],"lastnames":["Xie"],"firstnames":["Yakun"],"suffixes":[]},{"propositions":[],"lastnames":["Musielak"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Graeff"],"firstnames":["Moritz"],"suffixes":[]},{"propositions":[],"lastnames":["Stierhof"],"firstnames":["York-Dieter"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Hai"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Chun-Ming"],"suffixes":[]},{"propositions":[],"lastnames":["Wenkel"],"firstnames":["Stephan"],"suffixes":[]}],"month":"January","year":"2013","keywords":"AGO10, HD-ZIPIII transcription factors, LITTLE ZIPPER, Shoot apical meristem, microProteins, microRNAs","pages":"25–33","bibtex":"@article{brandt_control_2013,\n\tseries = {Developmental plasticity and adaptation in plants},\n\ttitle = {Control of stem cell homeostasis via interlocking {microRNA} and {microProtein} feedback loops},\n\tvolume = {130},\n\tissn = {0925-4773},\n\turl = {https://www.sciencedirect.com/science/article/pii/S0925477312000603},\n\tdoi = {10.1016/j.mod.2012.06.007},\n\tabstract = {Stem cells in the shoot apex of plants produce cells required for the formation of new leaves. Adult leaves are composed of multiple tissue layers arranged along the dorso-ventral (adaxial/abaxial) axis. Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play an important role in the set-up of leaf polarity in plants. Loss of HD-ZIPIII function results in strongly misshapen leaves and in severe cases fosters the consumption of the apical stem cells, thus causing a growth arrest in mutant plants. HD-ZIPIII mRNA is under tight control by microRNAs 165/166. In addition to the microRNA-action a second layer of regulation is established by LITTLE ZIPPER (ZPR)-type microProteins, which can interact with HD-ZIPIII proteins, forming attenuated protein complexes. Here we show that REVOLUTA (REV, a member of the HD-ZIPIII family) directly regulates the expression of ARGONAUTE10 (AGO10), ZPR1 and ZPR3. Because AGO10 was shown to dampen microRNA165/6 function, REV establishes a positive feedback loop on its own activity. Since ZPR-type microProteins are known to reduce HD-ZIPIII protein activity, REV concomitantly establishes a negative feedback loop. We propose that the interconnection of these microRNA/microProtein feedback loops regulates polarity set-up and stem cell activity in plants.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-11-30},\n\tjournal = {Mechanisms of Development},\n\tauthor = {Brandt, Ronny and Xie, Yakun and Musielak, Thomas and Graeff, Moritz and Stierhof, York-Dieter and Huang, Hai and Liu, Chun-Ming and Wenkel, Stephan},\n\tmonth = jan,\n\tyear = {2013},\n\tkeywords = {AGO10, HD-ZIPIII transcription factors, LITTLE ZIPPER, Shoot apical meristem, microProteins, microRNAs},\n\tpages = {25--33},\n}\n\n","author_short":["Brandt, R.","Xie, Y.","Musielak, T.","Graeff, M.","Stierhof, Y.","Huang, H.","Liu, C.","Wenkel, S."],"key":"brandt_control_2013","id":"brandt_control_2013","bibbaseid":"brandt-xie-musielak-graeff-stierhof-huang-liu-wenkel-controlofstemcellhomeostasisviainterlockingmicrornaandmicroproteinfeedbackloops-2013","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S0925477312000603"},"keyword":["AGO10","HD-ZIPIII transcription factors","LITTLE ZIPPER","Shoot apical meristem","microProteins","microRNAs"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["9cGcv2t8pRzC92kzs"],"keywords":["ago10","hd-zipiii transcription factors","little zipper","shoot apical meristem","microproteins","micrornas"],"search_terms":["control","stem","cell","homeostasis","via","interlocking","microrna","microprotein","feedback","loops","brandt","xie","musielak","graeff","stierhof","huang","liu","wenkel"],"title":"Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops","year":2013}