Synthesis of Novel bis-Triazolinedione Crosslinked Amphiphilic Polypept(o)ide Nanostructures. Brannigan, R., Kimmins, S., Bobbi, E., Caulfield, S., & Heise, A. Macromolecular Chemistry and Physics, 2019. abstract bibtex © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Owing to their wide range of inherent functionality, hydrolytic stability, biodegradability, and low toxicity, polypeptide-based materials have been increasingly exploited for controlled drug release applications. More recently, the incorporation of poly(α-peptoid)s such as poly(sarcosine) into polypeptide-based materials has been investigated owing to their potential as naturally derived “stealth polymers.” Here the synthesis of novel amphiphilic polypept(o)ide nanoparticles is described utilizing silica templates as a macroinitiator for the ring-opening copolymerization of l-tryptophan and d/l-phenylalanine NCAs and subsequent chain extension with sarcosine NCA. These particles are subsequently crosslinked utilizing the TAD-indole “click” chemistry and the silica templates are eroded via treatment with HF yielding core crosslinked amphiphilic polypept(o)ide nanostructures. This synthetic strategy offers a unique platform to yield naturally-derived degradable core-crosslinked nanostructures, which may have the potential to be utilized in the future as delivery vehicles for hydrophobic small molecules.
@article{
title = {Synthesis of Novel bis-Triazolinedione Crosslinked Amphiphilic Polypept(o)ide Nanostructures},
type = {article},
year = {2019},
identifiers = {[object Object]},
keywords = {amphiphiles,crosslinking,nanoparticles,peptides,ring-opening polymerization},
volume = {220},
id = {4d6f2b93-2dc6-3e31-95bb-08d393e7d365},
created = {2020-01-17T09:06:51.083Z},
file_attached = {false},
profile_id = {08bc4674-f202-3e3a-a4d5-6a57500ede0e},
last_modified = {2020-01-17T09:06:51.083Z},
read = {false},
starred = {false},
authored = {true},
confirmed = {false},
hidden = {false},
private_publication = {false},
abstract = {© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Owing to their wide range of inherent functionality, hydrolytic stability, biodegradability, and low toxicity, polypeptide-based materials have been increasingly exploited for controlled drug release applications. More recently, the incorporation of poly(α-peptoid)s such as poly(sarcosine) into polypeptide-based materials has been investigated owing to their potential as naturally derived “stealth polymers.” Here the synthesis of novel amphiphilic polypept(o)ide nanoparticles is described utilizing silica templates as a macroinitiator for the ring-opening copolymerization of l-tryptophan and d/l-phenylalanine NCAs and subsequent chain extension with sarcosine NCA. These particles are subsequently crosslinked utilizing the TAD-indole “click” chemistry and the silica templates are eroded via treatment with HF yielding core crosslinked amphiphilic polypept(o)ide nanostructures. This synthetic strategy offers a unique platform to yield naturally-derived degradable core-crosslinked nanostructures, which may have the potential to be utilized in the future as delivery vehicles for hydrophobic small molecules.},
bibtype = {article},
author = {Brannigan, R.P. and Kimmins, S.D. and Bobbi, E. and Caulfield, S. and Heise, A.},
journal = {Macromolecular Chemistry and Physics},
number = {11}
}
Downloads: 0
{"_id":"ttbKCnyJjmDLeBg5m","bibbaseid":"brannigan-kimmins-bobbi-caulfield-heise-synthesisofnovelbistriazolinedionecrosslinkedamphiphilicpolypeptoidenanostructures-2019","authorIDs":["u637xuZPu5iWDN4R5"],"author_short":["Brannigan, R.","Kimmins, S.","Bobbi, E.","Caulfield, S.","Heise, A."],"bibdata":{"title":"Synthesis of Novel bis-Triazolinedione Crosslinked Amphiphilic Polypept(o)ide Nanostructures","type":"article","year":"2019","identifiers":"[object Object]","keywords":"amphiphiles,crosslinking,nanoparticles,peptides,ring-opening polymerization","volume":"220","id":"4d6f2b93-2dc6-3e31-95bb-08d393e7d365","created":"2020-01-17T09:06:51.083Z","file_attached":false,"profile_id":"08bc4674-f202-3e3a-a4d5-6a57500ede0e","last_modified":"2020-01-17T09:06:51.083Z","read":false,"starred":false,"authored":"true","confirmed":false,"hidden":false,"private_publication":false,"abstract":"© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Owing to their wide range of inherent functionality, hydrolytic stability, biodegradability, and low toxicity, polypeptide-based materials have been increasingly exploited for controlled drug release applications. More recently, the incorporation of poly(α-peptoid)s such as poly(sarcosine) into polypeptide-based materials has been investigated owing to their potential as naturally derived “stealth polymers.” Here the synthesis of novel amphiphilic polypept(o)ide nanoparticles is described utilizing silica templates as a macroinitiator for the ring-opening copolymerization of l-tryptophan and d/l-phenylalanine NCAs and subsequent chain extension with sarcosine NCA. These particles are subsequently crosslinked utilizing the TAD-indole “click” chemistry and the silica templates are eroded via treatment with HF yielding core crosslinked amphiphilic polypept(o)ide nanostructures. This synthetic strategy offers a unique platform to yield naturally-derived degradable core-crosslinked nanostructures, which may have the potential to be utilized in the future as delivery vehicles for hydrophobic small molecules.","bibtype":"article","author":"Brannigan, R.P. and Kimmins, S.D. and Bobbi, E. and Caulfield, S. and Heise, A.","journal":"Macromolecular Chemistry and Physics","number":"11","bibtex":"@article{\n title = {Synthesis of Novel bis-Triazolinedione Crosslinked Amphiphilic Polypept(o)ide Nanostructures},\n type = {article},\n year = {2019},\n identifiers = {[object Object]},\n keywords = {amphiphiles,crosslinking,nanoparticles,peptides,ring-opening polymerization},\n volume = {220},\n id = {4d6f2b93-2dc6-3e31-95bb-08d393e7d365},\n created = {2020-01-17T09:06:51.083Z},\n file_attached = {false},\n profile_id = {08bc4674-f202-3e3a-a4d5-6a57500ede0e},\n last_modified = {2020-01-17T09:06:51.083Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Owing to their wide range of inherent functionality, hydrolytic stability, biodegradability, and low toxicity, polypeptide-based materials have been increasingly exploited for controlled drug release applications. More recently, the incorporation of poly(α-peptoid)s such as poly(sarcosine) into polypeptide-based materials has been investigated owing to their potential as naturally derived “stealth polymers.” Here the synthesis of novel amphiphilic polypept(o)ide nanoparticles is described utilizing silica templates as a macroinitiator for the ring-opening copolymerization of l-tryptophan and d/l-phenylalanine NCAs and subsequent chain extension with sarcosine NCA. These particles are subsequently crosslinked utilizing the TAD-indole “click” chemistry and the silica templates are eroded via treatment with HF yielding core crosslinked amphiphilic polypept(o)ide nanostructures. This synthetic strategy offers a unique platform to yield naturally-derived degradable core-crosslinked nanostructures, which may have the potential to be utilized in the future as delivery vehicles for hydrophobic small molecules.},\n bibtype = {article},\n author = {Brannigan, R.P. and Kimmins, S.D. and Bobbi, E. and Caulfield, S. and Heise, A.},\n journal = {Macromolecular Chemistry and Physics},\n number = {11}\n}","author_short":["Brannigan, R.","Kimmins, S.","Bobbi, E.","Caulfield, S.","Heise, A."],"bibbaseid":"brannigan-kimmins-bobbi-caulfield-heise-synthesisofnovelbistriazolinedionecrosslinkedamphiphilicpolypeptoidenanostructures-2019","role":"author","urls":{},"keyword":["amphiphiles","crosslinking","nanoparticles","peptides","ring-opening polymerization"],"downloads":0},"bibtype":"article","creationDate":"2020-04-25T15:46:44.410Z","downloads":0,"keywords":["amphiphiles","crosslinking","nanoparticles","peptides","ring-opening polymerization"],"search_terms":["synthesis","novel","bis","triazolinedione","crosslinked","amphiphilic","polypept","ide","nanostructures","brannigan","kimmins","bobbi","caulfield","heise"],"title":"Synthesis of Novel bis-Triazolinedione Crosslinked Amphiphilic Polypept(o)ide Nanostructures","year":2019}