{"_id":"6pGBtNZ6X2xtcjj9u","bibbaseid":"breitling-pitt-barrett-precisionmappingofthemetabolome-2006","authorIDs":[],"author_short":["Breitling, R.","Pitt, A. R","Barrett, M. P"],"bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["Rainer"],"propositions":[],"lastnames":["Breitling"],"suffixes":[]},{"firstnames":["Andrew","R"],"propositions":[],"lastnames":["Pitt"],"suffixes":[]},{"firstnames":["Michael","P"],"propositions":[],"lastnames":["Barrett"],"suffixes":[]}],"title":"Precision mapping of the metabolome","journal":"Trends Biotechnol","year":"2006","volume":"24","number":"12","pages":"543–548","abstract":"The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism.","doi":"10.1016/j.tibtech.2006.10.006","file":"BreitlingEtAl_PrecisionMappingMetabolome_TrendsBiotech_2006.pdf:2006/BreitlingEtAl_PrecisionMappingMetabolome_TrendsBiotech_2006.pdf:PDF","keywords":"metabolite ms","owner":"rasche","pmid":"17064801","timestamp":"11.09.2008","bibtex":"@Article{breitling06precision,\n author = {Rainer Breitling and Andrew R Pitt and Michael P Barrett},\n title = {Precision mapping of the metabolome},\n journal = {Trends Biotechnol},\n year = {2006},\n volume = {24},\n number = {12},\n pages = {543--548},\n abstract = {The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism.},\n doi = {10.1016/j.tibtech.2006.10.006},\n file = {BreitlingEtAl_PrecisionMappingMetabolome_TrendsBiotech_2006.pdf:2006/BreitlingEtAl_PrecisionMappingMetabolome_TrendsBiotech_2006.pdf:PDF},\n keywords = {metabolite ms},\n owner = {rasche},\n pmid = {17064801},\n timestamp = {11.09.2008},\n}\n\n","author_short":["Breitling, R.","Pitt, A. R","Barrett, M. P"],"key":"breitling06precision","id":"breitling06precision","bibbaseid":"breitling-pitt-barrett-precisionmappingofthemetabolome-2006","role":"author","urls":{},"keyword":["metabolite ms"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://git.bio.informatik.uni-jena.de/fleisch/literature/raw/master/group-literature.bib","creationDate":"2019-11-19T16:50:41.665Z","downloads":0,"keywords":["metabolite ms"],"search_terms":["precision","mapping","metabolome","breitling","pitt","barrett"],"title":"Precision mapping of the metabolome","year":2006,"dataSources":["C5FtkvWWggFfMJTFX"]}