@article{Brombacher2020,
abstract = {Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared.},
author = {Brombacher, T M and Berkiks, I and Pillay, S and Scibiorek, Martyna and Moses, B O and Brombacher, Frank},
doi = {10.1038/s41598-020-73574-3},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Brombacher et al. - 2020 - IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory.pdf:pdf},
issn = {2045-2322},
journal = {Scientific Reports},
keywords = {Behavioural methods,Immunological techniques,Immunology,Molecular biology,Neuroscience,OA,Psychology,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {dec},
pages = {16506},
pmid = {33020569},
publisher = {Nature Publishing Group},
title = {{IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory}},
url = {http://www.nature.com/articles/s41598-020-73574-3},
volume = {10},
year = {2020}
}

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