Novel electrocardiographic screening criterion for hypertrophic cardiomyopathy in children. Brothers, M., Oster, M., Ehrlich, A, Strieper, M., & Mahle, W. Am J Cardiol, 113(7):1246–1249, April, 2014. ![Novel electrocardiographic screening criterion for hypertrophic cardiomyopathy in children. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Electrocardiography is often advocated as a screening tool in children for hypertrophic cardiomyopathy (HC). We sought to establish an electrocardiographic screening tool to identify children with HC. We hypothesized that a pediatric-specific electrocardiographic criterion would perform better than the popular criteria used for screening children for left ventricular hypertrophy and HC. The earliest available electrocardiogram for children (n=108) with HC (ages 7 to 21 yrs) was reviewed. We sought to compare the diagnostic accuracy of 4 screening algorithms: (1) Sokolow-Lyon criterion (SV1+RV5/RV6\textgreater35 mm), (2) Cornell criterion (RaVL+SV3\textgreater28 mm in men, 20 mm in women), (3) total 12-lead voltage criterion (R wave to the nadir of Q/S wave\textgreater175 mm), and (4) pediatric-specific criterion (RaVL+SV2\textgreater23 mm). The same criteria were applied to a cohort of age-matched and gender-matched controls without cardiac disease. Statistically significant correlations were found between children with HC and positive screen using all 4 criteria. However, comparison of receiver operating characteristic demonstrated an area under the curve of 0.67 for Sokolow-Lyon criterion, 0.70 for Cornell criterion, 0.83 for total 12-lead criterion, and 0.82 for pediatric-specific criterion. Pediatric-specific criterion had superior sensitivity in gene-positive children and superior overall specificity than total 12-lead criterion. In conclusion, our study demonstrates that the pediatric-specific criterion employing leads RaVL+SV2 is more accurate in identifying children with HC in comparison with other popular screening criteria.
@article{brothers_novel_2014,
title = {Novel electrocardiographic screening criterion for hypertrophic cardiomyopathy in children.},
volume = {113},
url = {https://www.ncbi.nlm.nih.gov/pubmed/24513471},
doi = {10.1016/j.amjcard.2013.12.039},
abstract = {Electrocardiography is often advocated as a screening tool in children for hypertrophic cardiomyopathy (HC). We sought to establish an electrocardiographic screening tool to identify children with HC. We hypothesized that a pediatric-specific electrocardiographic criterion would perform better than the popular criteria used for screening children for left ventricular hypertrophy and HC. The earliest available electrocardiogram for children (n=108) with HC (ages 7 to 21 yrs) was reviewed. We sought to compare the diagnostic accuracy of 4 screening algorithms: (1) Sokolow-Lyon criterion (SV1+RV5/RV6{\textgreater}35 mm), (2) Cornell criterion (RaVL+SV3{\textgreater}28 mm in men, 20 mm in women), (3) total 12-lead voltage criterion (R wave to the nadir of Q/S wave{\textgreater}175 mm), and (4) pediatric-specific criterion (RaVL+SV2{\textgreater}23 mm). The same criteria were applied to a cohort of age-matched and gender-matched controls without cardiac disease. Statistically significant correlations were found between children with HC and positive screen using all 4 criteria. However, comparison of receiver operating characteristic demonstrated an area under the curve of 0.67 for Sokolow-Lyon criterion, 0.70 for Cornell criterion, 0.83 for total 12-lead criterion, and 0.82 for pediatric-specific criterion. Pediatric-specific criterion had superior sensitivity in gene-positive children and superior overall specificity than total 12-lead criterion. In conclusion, our study demonstrates that the pediatric-specific criterion employing leads RaVL+SV2 is more accurate in identifying children with HC in comparison with other popular screening criteria.},
language = {eng},
number = {7},
journal = {Am J Cardiol},
author = {Brothers, MB and Oster, ME and Ehrlich, A and Strieper, MJ and Mahle, WT},
month = apr,
year = {2014},
keywords = {Young Adult},
pages = {1246--1249}
}
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We sought to establish an electrocardiographic screening tool to identify children with HC. We hypothesized that a pediatric-specific electrocardiographic criterion would perform better than the popular criteria used for screening children for left ventricular hypertrophy and HC. The earliest available electrocardiogram for children (n=108) with HC (ages 7 to 21 yrs) was reviewed. We sought to compare the diagnostic accuracy of 4 screening algorithms: (1) Sokolow-Lyon criterion (SV1+RV5/RV6\\textgreater35 mm), (2) Cornell criterion (RaVL+SV3\\textgreater28 mm in men, 20 mm in women), (3) total 12-lead voltage criterion (R wave to the nadir of Q/S wave\\textgreater175 mm), and (4) pediatric-specific criterion (RaVL+SV2\\textgreater23 mm). The same criteria were applied to a cohort of age-matched and gender-matched controls without cardiac disease. Statistically significant correlations were found between children with HC and positive screen using all 4 criteria. However, comparison of receiver operating characteristic demonstrated an area under the curve of 0.67 for Sokolow-Lyon criterion, 0.70 for Cornell criterion, 0.83 for total 12-lead criterion, and 0.82 for pediatric-specific criterion. Pediatric-specific criterion had superior sensitivity in gene-positive children and superior overall specificity than total 12-lead criterion. 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