@inproceedings{ mendeley_5328713411,
  isauthor = {1},
  isbn = {9781457717871},
  abstract = {Heart rate variability (HRV) may provide anesthesiologists with a noninvasive tool for monitoring nociception during general anesthesia. A novel real-time cardiorespiratory coherence (CRC) algorithm has been developed to analyze the strength of linear coupling between heart rate (HR) and respiration. CRC values range from 0 (low coherence, strong nociception) to 1 (high coherence, no nociception). The algorithm uses specially designed filters to operate in real-time, minimizing computational complexity and time delay. In the standard HRV high frequency band of 0.15 - 0.4 Hz, the real-time delay is only 5.25 - 3.25 s. We have assessed the algorithm's response to 60 anesthetic bolus events (a large dose of anesthetics given over a short time; strongly antinociceptive) recorded in 47 pediatric patients receiving general anesthesia. Real-time CRC responded strongly to bolus events, changing by an average of 30%. For comparison, three traditional measures of HRV (LF/HF ratio, SDNN, and RMSSD) responded on average by only 3.8%, 14%, and 3.9%, respectively. Finally, two traditional clinical measures of nociception (HR and blood pressure) responded on average by only 3.9% and 0.91%, respectively. CRC may thus be used as a real-time nociception monitor during general anesthesia.},
  month = {1},
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  year = {2012},
  isstarred = {0},
  id = {5328713411},
  discipline = {Medicine},
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  title = {Real-time cardiorespiratory coherence detects antinociception during general anesthesia.},
  series = {Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  version = {1392489909},
  pmid = {23366759},
  folders_ids = {33032201, 33032671},
  type = {Conference Proceedings},
  url_pdf_0 = {http://www.mendeley.com/download/public/14667/5328713411/d3677a8d5fb6ab9e44b705c67c496a6c699cc707/dl.pdf},
  url_mendeley = {http://www.mendeley.com/catalog/realtime-cardiorespiratory-coherence-detects-antinociception-during-general-anesthesia/},
  volume = {2012},
  isread = {0},
  author = {Chris J {Brouse} and Walter {Karlen} and Guy a {Dumont} and Dorothy {Myers} and Erin {Cooke} and Jonathan {Stinson} and Joanne {Lim} and J Mark {Ansermino}},
  pages = {3813-6},
  doi = {10.1109/EMBC.2012.6346798},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/23366759},
  issn = {1557-170X},
  modified = {1392489909},
  citation_key = {Brouse2012b},
  booktitle = {Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  subdiscipline = {Biomedical Engineering}
}

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A novel real-time cardiorespiratory coherence (CRC) algorithm has been developed to analyze the strength of linear coupling between heart rate (HR) and respiration. CRC values range from 0 (low coherence, strong nociception) to 1 (high coherence, no nociception). The algorithm uses specially designed filters to operate in real-time, minimizing computational complexity and time delay. In the standard HRV high frequency band of 0.15 - 0.4 Hz, the real-time delay is only 5.25 - 3.25 s. We have assessed the algorithm's response to 60 anesthetic bolus events (a large dose of anesthetics given over a short time; strongly antinociceptive) recorded in 47 pediatric patients receiving general anesthesia. Real-time CRC responded strongly to bolus events, changing by an average of 30%. For comparison, three traditional measures of HRV (LF/HF ratio, SDNN, and RMSSD) responded on average by only 3.8%, 14%, and 3.9%, respectively. Finally, two traditional clinical measures of nociception (HR and blood pressure) responded on average by only 3.9% and 0.91%, respectively. 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A novel real-time cardiorespiratory coherence (CRC) algorithm has been developed to analyze the strength of linear coupling between heart rate (HR) and respiration. CRC values range from 0 (low coherence, strong nociception) to 1 (high coherence, no nociception). The algorithm uses specially designed filters to operate in real-time, minimizing computational complexity and time delay. In the standard HRV high frequency band of 0.15 - 0.4 Hz, the real-time delay is only 5.25 - 3.25 s. We have assessed the algorithm's response to 60 anesthetic bolus events (a large dose of anesthetics given over a short time; strongly antinociceptive) recorded in 47 pediatric patients receiving general anesthesia. Real-time CRC responded strongly to bolus events, changing by an average of 30%. For comparison, three traditional measures of HRV (LF/HF ratio, SDNN, and RMSSD) responded on average by only 3.8%, 14%, and 3.9%, respectively. Finally, two traditional clinical measures of nociception (HR and blood pressure) responded on average by only 3.9% and 0.91%, respectively. CRC may thus be used as a real-time nociception monitor during general anesthesia."},"bibtype":"inproceedings","biburl":"http://www.bibbase.org/mendeley/cf8d5c89d9","downloads":0,"keywords":[],"search_terms":["real","time","cardiorespiratory","coherence","detects","antinociception","during","general","anesthesia","brouse","karlen","a<nbsp>dumont","myers","cooke","stinson","lim","ansermino"],"title":"Real-time cardiorespiratory coherence detects antinociception during general anesthesia.","year":2012,"dataSources":["FerxM5S9yDpX5t5AF"]}