Using Attentional Bias Modification as a Cognitive Vaccine Against Depression. Browning, M., Holmes, E. A., Charles, M., Cowen, P. J., & Harmer, C. J. Biological Psychiatry, 72(7):572--579, 2012. ![Using Attentional Bias Modification as a Cognitive Vaccine Against Depression [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Negative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention of the illness. However, no previous study has tested whether reducing negative attentional bias causally affects risk factors for depressive recurrence. The current experimental medicine study reports the effects of a computerized attentional bias modification (ABM) procedure on intermediate measures of the risk of depressive recurrence (residual depressive symptoms and the cortisol awakening response) in patients with recurrent depression. Methods Sixty-one patients with at least two previous episodes of depression who were currently in remission were randomized to receive either an active (positive) or placebo computer-based ABM regime. The ABM regime presented either pictures of faces or words. Residual depressive symptoms, measured using the Beck Depression Inventory and the cortisol awakening response were measured immediately before and after completion of the bias modification and then again after 4 weeks' follow-up. Results Positive, face-based ABM reduced both measures of recurrence risk (Beck Depression Inventory and cortisol awakening response). This effect occurred during the month following completion of bias modification. Word-based modification did not influence the outcome measures. Conclusions Positive face-based ABM was able to reduce intermediate measures of recurrence risk in previously depressed patients. These results suggest that ABM may provide a “cognitive vaccine” against depression and offer a useful strategy in the secondary prevention of the illness.
@article{browning_using_2012,
series = {Novel {Pharmacotherapies} for {Depression}},
title = {Using {Attentional} {Bias} {Modification} as a {Cognitive} {Vaccine} {Against} {Depression}},
volume = {72},
issn = {0006-3223},
url = {http://www.sciencedirect.com/science/article/pii/S0006322312003654},
doi = {10.1016/j.biopsych.2012.04.014},
abstract = {Background
Negative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention of the illness. However, no previous study has tested whether reducing negative attentional bias causally affects risk factors for depressive recurrence. The current experimental medicine study reports the effects of a computerized attentional bias modification (ABM) procedure on intermediate measures of the risk of depressive recurrence (residual depressive symptoms and the cortisol awakening response) in patients with recurrent depression.
Methods
Sixty-one patients with at least two previous episodes of depression who were currently in remission were randomized to receive either an active (positive) or placebo computer-based ABM regime. The ABM regime presented either pictures of faces or words. Residual depressive symptoms, measured using the Beck Depression Inventory and the cortisol awakening response were measured immediately before and after completion of the bias modification and then again after 4 weeks' follow-up.
Results
Positive, face-based ABM reduced both measures of recurrence risk (Beck Depression Inventory and cortisol awakening response). This effect occurred during the month following completion of bias modification. Word-based modification did not influence the outcome measures.
Conclusions
Positive face-based ABM was able to reduce intermediate measures of recurrence risk in previously depressed patients. These results suggest that ABM may provide a “cognitive vaccine” against depression and offer a useful strategy in the secondary prevention of the illness.},
number = {7},
urldate = {2015-08-06TZ},
journal = {Biological Psychiatry},
author = {Browning, Michael and Holmes, Emily A. and Charles, Matthew and Cowen, Philip J. and Harmer, Catherine J.},
year = {2012},
keywords = {Attention, cognitive bias, depression, experimental medicine, prevention},
pages = {572--579}
}
Downloads: 0
{"_id":"Ls393eQZ56iWtCouc","bibbaseid":"browning-holmes-charles-cowen-harmer-usingattentionalbiasmodificationasacognitivevaccineagainstdepression-2012","downloads":0,"creationDate":"2016-03-16T14:38:25.567Z","title":"Using Attentional Bias Modification as a Cognitive Vaccine Against Depression","author_short":["Browning, M.","Holmes, E. A.","Charles, M.","Cowen, P. J.","Harmer, C. J."],"year":2012,"bibtype":"article","biburl":"http://bibbase.org/zotero/hogsford","bibdata":{"bibtype":"article","type":"article","series":"Novel Pharmacotherapies for Depression","title":"Using Attentional Bias Modification as a Cognitive Vaccine Against Depression","volume":"72","issn":"0006-3223","url":"http://www.sciencedirect.com/science/article/pii/S0006322312003654","doi":"10.1016/j.biopsych.2012.04.014","abstract":"Background Negative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention of the illness. However, no previous study has tested whether reducing negative attentional bias causally affects risk factors for depressive recurrence. The current experimental medicine study reports the effects of a computerized attentional bias modification (ABM) procedure on intermediate measures of the risk of depressive recurrence (residual depressive symptoms and the cortisol awakening response) in patients with recurrent depression. Methods Sixty-one patients with at least two previous episodes of depression who were currently in remission were randomized to receive either an active (positive) or placebo computer-based ABM regime. The ABM regime presented either pictures of faces or words. Residual depressive symptoms, measured using the Beck Depression Inventory and the cortisol awakening response were measured immediately before and after completion of the bias modification and then again after 4 weeks' follow-up. Results Positive, face-based ABM reduced both measures of recurrence risk (Beck Depression Inventory and cortisol awakening response). This effect occurred during the month following completion of bias modification. Word-based modification did not influence the outcome measures. Conclusions Positive face-based ABM was able to reduce intermediate measures of recurrence risk in previously depressed patients. These results suggest that ABM may provide a “cognitive vaccine” against depression and offer a useful strategy in the secondary prevention of the illness.","number":"7","urldate":"2015-08-06TZ","journal":"Biological Psychiatry","author":[{"propositions":[],"lastnames":["Browning"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["Holmes"],"firstnames":["Emily","A."],"suffixes":[]},{"propositions":[],"lastnames":["Charles"],"firstnames":["Matthew"],"suffixes":[]},{"propositions":[],"lastnames":["Cowen"],"firstnames":["Philip","J."],"suffixes":[]},{"propositions":[],"lastnames":["Harmer"],"firstnames":["Catherine","J."],"suffixes":[]}],"year":"2012","keywords":"Attention, cognitive bias, depression, experimental medicine, prevention","pages":"572--579","bibtex":"@article{browning_using_2012,\n\tseries = {Novel {Pharmacotherapies} for {Depression}},\n\ttitle = {Using {Attentional} {Bias} {Modification} as a {Cognitive} {Vaccine} {Against} {Depression}},\n\tvolume = {72},\n\tissn = {0006-3223},\n\turl = {http://www.sciencedirect.com/science/article/pii/S0006322312003654},\n\tdoi = {10.1016/j.biopsych.2012.04.014},\n\tabstract = {Background\nNegative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention of the illness. However, no previous study has tested whether reducing negative attentional bias causally affects risk factors for depressive recurrence. The current experimental medicine study reports the effects of a computerized attentional bias modification (ABM) procedure on intermediate measures of the risk of depressive recurrence (residual depressive symptoms and the cortisol awakening response) in patients with recurrent depression.\nMethods\nSixty-one patients with at least two previous episodes of depression who were currently in remission were randomized to receive either an active (positive) or placebo computer-based ABM regime. The ABM regime presented either pictures of faces or words. Residual depressive symptoms, measured using the Beck Depression Inventory and the cortisol awakening response were measured immediately before and after completion of the bias modification and then again after 4 weeks' follow-up.\nResults\nPositive, face-based ABM reduced both measures of recurrence risk (Beck Depression Inventory and cortisol awakening response). This effect occurred during the month following completion of bias modification. Word-based modification did not influence the outcome measures.\nConclusions\nPositive face-based ABM was able to reduce intermediate measures of recurrence risk in previously depressed patients. These results suggest that ABM may provide a “cognitive vaccine” against depression and offer a useful strategy in the secondary prevention of the illness.},\n\tnumber = {7},\n\turldate = {2015-08-06TZ},\n\tjournal = {Biological Psychiatry},\n\tauthor = {Browning, Michael and Holmes, Emily A. and Charles, Matthew and Cowen, Philip J. and Harmer, Catherine J.},\n\tyear = {2012},\n\tkeywords = {Attention, cognitive bias, depression, experimental medicine, prevention},\n\tpages = {572--579}\n}\n\n","author_short":["Browning, M.","Holmes, E. A.","Charles, M.","Cowen, P. J.","Harmer, C. J."],"key":"browning_using_2012","id":"browning_using_2012","bibbaseid":"browning-holmes-charles-cowen-harmer-usingattentionalbiasmodificationasacognitivevaccineagainstdepression-2012","role":"author","urls":{"Paper":"http://www.sciencedirect.com/science/article/pii/S0006322312003654"},"keyword":["Attention","cognitive bias","depression","experimental medicine","prevention"],"downloads":0},"search_terms":["using","attentional","bias","modification","cognitive","vaccine","against","depression","browning","holmes","charles","cowen","harmer"],"keywords":["attention","cognitive bias","depression","experimental medicine","prevention"],"authorIDs":[],"dataSources":["v98BPm7u4WMoReKPh"]}