Rotavirus Related Hospitalizations are Responsible for High Seasonal Peaks in All-Cause Pediatric Hospitalizations

Rotavirus Related Hospitalizations are Responsible for High Seasonal Peaks in All-Cause Pediatric Hospitalizations. Bruijning-Verhagen, P., Sankatsing, V., Kunst, A., van den Born, C., Bleeker, E., Thijsen, S., Ijzerman, E. P F, van der Velden, V. H J, & Bonten, M. J M The Pediatric infectious disease journal, July, 2012.

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BACKGROUND:: Seasonal rotavirus (RV) epidemics partly overlap with those of other common childhood infections thereby generating enormous - but poorly quantified - pressure on hospital resources during winter and spring. We assessed RV contribution to seasonal excess in all-cause pediatric hospitalizations and RV hospitalizations incidence rate in an observational study. METHODS:: The study was conducted among pediatric wards in 3 general hospitals and one pediatric tertiary care center. Numbers of RV hospitalizations were determined from 5 year data on confirmed RV hospitalizations and adjusted for RV underreporting, assessed through active surveillance for acute gastroenteritis during the 2011 RV season. Incidence rate and RV contribution to all-cause hospitalizations was determined upon hospital administrative data and population statistics. RESULTS:: RV accounted for 6.2% (95%CI: 5.3 - 7.1) of all-cause pediatric hospitalizations among general hospitals and 3.1% (95%CI: 2.9 - 3.3) at the tertiary care center, adjusted for the proportion RV underreporting among gastroenteritis patients (33%) as observed during active surveillance. Among general hospitals, there was a 30% increase in all-cause hospitalizations during the active season of common childhood infections compared with summer months. RV contributed 31% to seasonal excess in all-cause pediatric hospitalizations, representing 12.9% of hospitalizations between January and May. RV hospitalizations incidence rate in the population was 510/100,000 child-years less than 5 years (95%CI: 420-600). CONCLUSION:: RV is one of the main causes of seasonal peaks in pediatric hospitalizations, and as such contributes significantly to periodic high bed-capacity pressures and associated adverse effects. RV vaccination benefits in this respect should be considered in decision-making processes.

@article{bruijning-verhagen_rotavirus_2012,
	title = {Rotavirus {Related} {Hospitalizations} are {Responsible} for {High} {Seasonal} {Peaks} in {All}-{Cause} {Pediatric} {Hospitalizations}},
	issn = {1532-0987},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22828647},
	doi = {10.1097/INF.0b013e31826a5ba1},
	abstract = {BACKGROUND:: Seasonal rotavirus (RV) epidemics partly overlap with those of other common childhood infections thereby generating enormous - but poorly quantified - pressure on hospital resources during winter and spring. We assessed RV contribution to seasonal excess in all-cause pediatric hospitalizations and RV hospitalizations incidence rate in an observational study. METHODS:: The study was conducted among pediatric wards in 3 general hospitals and one pediatric tertiary care center. Numbers of RV hospitalizations were determined from 5 year data on confirmed RV hospitalizations and adjusted for RV underreporting, assessed through active surveillance for acute gastroenteritis during the 2011 RV season. Incidence rate and RV contribution to all-cause hospitalizations was determined upon hospital administrative data and population statistics. RESULTS:: RV accounted for 6.2\% (95\%CI: 5.3 - 7.1) of all-cause pediatric hospitalizations among general hospitals and 3.1\% (95\%CI: 2.9 - 3.3) at the tertiary care center, adjusted for the proportion RV underreporting among gastroenteritis patients (33\%) as observed during active surveillance. Among general hospitals, there was a 30\% increase in all-cause hospitalizations during the active season of common childhood infections compared with summer months. RV contributed 31\% to seasonal excess in all-cause pediatric hospitalizations, representing 12.9\% of hospitalizations between January and May. RV hospitalizations incidence rate in the population was 510/100,000 child-years less than 5 years (95\%CI: 420-600). CONCLUSION:: RV is one of the main causes of seasonal peaks in pediatric hospitalizations, and as such contributes significantly to periodic high bed-capacity pressures and associated adverse effects. RV vaccination benefits in this respect should be considered in decision-making processes.},
	urldate = {2012-09-03},
	journal = {The Pediatric infectious disease journal},
	author = {Bruijning-Verhagen, Patricia and Sankatsing, Valerie and Kunst, Annemieke and van den Born, Charlie and Bleeker, Esther and Thijsen, Steven and Ijzerman, Ed P F and van der Velden, Vincent H J and Bonten, Marc J M},
	month = jul,
	year = {2012},
	pmid = {22828647},
}

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{"_id":"kHscn2dBBScYkxBXM","bibbaseid":"bruijningverhagen-sankatsing-kunst-vandenborn-bleeker-thijsen-ijzerman-vandervelden-etal-rotavirusrelatedhospitalizationsareresponsibleforhighseasonalpeaksinallcausepediatrichospitalizations-2012","author_short":["Bruijning-Verhagen, P.","Sankatsing, V.","Kunst, A.","van den Born, C.","Bleeker, E.","Thijsen, S.","Ijzerman, E. P F","van der Velden, V. H J","Bonten, M. J M"],"bibdata":{"bibtype":"article","type":"article","title":"Rotavirus Related Hospitalizations are Responsible for High Seasonal Peaks in All-Cause Pediatric Hospitalizations","issn":"1532-0987","url":"http://www.ncbi.nlm.nih.gov/pubmed/22828647","doi":"10.1097/INF.0b013e31826a5ba1","abstract":"BACKGROUND:: Seasonal rotavirus (RV) epidemics partly overlap with those of other common childhood infections thereby generating enormous - but poorly quantified - pressure on hospital resources during winter and spring. We assessed RV contribution to seasonal excess in all-cause pediatric hospitalizations and RV hospitalizations incidence rate in an observational study. METHODS:: The study was conducted among pediatric wards in 3 general hospitals and one pediatric tertiary care center. Numbers of RV hospitalizations were determined from 5 year data on confirmed RV hospitalizations and adjusted for RV underreporting, assessed through active surveillance for acute gastroenteritis during the 2011 RV season. Incidence rate and RV contribution to all-cause hospitalizations was determined upon hospital administrative data and population statistics. RESULTS:: RV accounted for 6.2% (95%CI: 5.3 - 7.1) of all-cause pediatric hospitalizations among general hospitals and 3.1% (95%CI: 2.9 - 3.3) at the tertiary care center, adjusted for the proportion RV underreporting among gastroenteritis patients (33%) as observed during active surveillance. Among general hospitals, there was a 30% increase in all-cause hospitalizations during the active season of common childhood infections compared with summer months. RV contributed 31% to seasonal excess in all-cause pediatric hospitalizations, representing 12.9% of hospitalizations between January and May. RV hospitalizations incidence rate in the population was 510/100,000 child-years less than 5 years (95%CI: 420-600). CONCLUSION:: RV is one of the main causes of seasonal peaks in pediatric hospitalizations, and as such contributes significantly to periodic high bed-capacity pressures and associated adverse effects. RV vaccination benefits in this respect should be considered in decision-making processes.","urldate":"2012-09-03","journal":"The Pediatric infectious disease journal","author":[{"propositions":[],"lastnames":["Bruijning-Verhagen"],"firstnames":["Patricia"],"suffixes":[]},{"propositions":[],"lastnames":["Sankatsing"],"firstnames":["Valerie"],"suffixes":[]},{"propositions":[],"lastnames":["Kunst"],"firstnames":["Annemieke"],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Born"],"firstnames":["Charlie"],"suffixes":[]},{"propositions":[],"lastnames":["Bleeker"],"firstnames":["Esther"],"suffixes":[]},{"propositions":[],"lastnames":["Thijsen"],"firstnames":["Steven"],"suffixes":[]},{"propositions":[],"lastnames":["Ijzerman"],"firstnames":["Ed","P","F"],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Velden"],"firstnames":["Vincent","H","J"],"suffixes":[]},{"propositions":[],"lastnames":["Bonten"],"firstnames":["Marc","J","M"],"suffixes":[]}],"month":"July","year":"2012","pmid":"22828647","bibtex":"@article{bruijning-verhagen_rotavirus_2012,\n\ttitle = {Rotavirus {Related} {Hospitalizations} are {Responsible} for {High} {Seasonal} {Peaks} in {All}-{Cause} {Pediatric} {Hospitalizations}},\n\tissn = {1532-0987},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/22828647},\n\tdoi = {10.1097/INF.0b013e31826a5ba1},\n\tabstract = {BACKGROUND:: Seasonal rotavirus (RV) epidemics partly overlap with those of other common childhood infections thereby generating enormous - but poorly quantified - pressure on hospital resources during winter and spring. We assessed RV contribution to seasonal excess in all-cause pediatric hospitalizations and RV hospitalizations incidence rate in an observational study. METHODS:: The study was conducted among pediatric wards in 3 general hospitals and one pediatric tertiary care center. Numbers of RV hospitalizations were determined from 5 year data on confirmed RV hospitalizations and adjusted for RV underreporting, assessed through active surveillance for acute gastroenteritis during the 2011 RV season. Incidence rate and RV contribution to all-cause hospitalizations was determined upon hospital administrative data and population statistics. RESULTS:: RV accounted for 6.2\\% (95\\%CI: 5.3 - 7.1) of all-cause pediatric hospitalizations among general hospitals and 3.1\\% (95\\%CI: 2.9 - 3.3) at the tertiary care center, adjusted for the proportion RV underreporting among gastroenteritis patients (33\\%) as observed during active surveillance. Among general hospitals, there was a 30\\% increase in all-cause hospitalizations during the active season of common childhood infections compared with summer months. RV contributed 31\\% to seasonal excess in all-cause pediatric hospitalizations, representing 12.9\\% of hospitalizations between January and May. RV hospitalizations incidence rate in the population was 510/100,000 child-years less than 5 years (95\\%CI: 420-600). CONCLUSION:: RV is one of the main causes of seasonal peaks in pediatric hospitalizations, and as such contributes significantly to periodic high bed-capacity pressures and associated adverse effects. RV vaccination benefits in this respect should be considered in decision-making processes.},\n\turldate = {2012-09-03},\n\tjournal = {The Pediatric infectious disease journal},\n\tauthor = {Bruijning-Verhagen, Patricia and Sankatsing, Valerie and Kunst, Annemieke and van den Born, Charlie and Bleeker, Esther and Thijsen, Steven and Ijzerman, Ed P F and van der Velden, Vincent H J and Bonten, Marc J M},\n\tmonth = jul,\n\tyear = {2012},\n\tpmid = {22828647},\n}\n\n","author_short":["Bruijning-Verhagen, P.","Sankatsing, V.","Kunst, A.","van den Born, C.","Bleeker, E.","Thijsen, S.","Ijzerman, E. P F","van der Velden, V. H J","Bonten, M. J M"],"key":"bruijning-verhagen_rotavirus_2012","id":"bruijning-verhagen_rotavirus_2012","bibbaseid":"bruijningverhagen-sankatsing-kunst-vandenborn-bleeker-thijsen-ijzerman-vandervelden-etal-rotavirusrelatedhospitalizationsareresponsibleforhighseasonalpeaksinallcausepediatrichospitalizations-2012","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/22828647"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":[],"search_terms":["rotavirus","related","hospitalizations","responsible","high","seasonal","peaks","cause","pediatric","hospitalizations","bruijning-verhagen","sankatsing","kunst","van den born","bleeker","thijsen","ijzerman","van der velden","bonten"],"title":"Rotavirus Related Hospitalizations are Responsible for High Seasonal Peaks in All-Cause Pediatric Hospitalizations","year":2012}