@article{
 title = {Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 pages = {1622-1627},
 volume = {312},
 websites = {http://www.sciencemag.org/content/312/5780/1622.abstract},
 id = {50f175a6-a1f8-3349-93dc-01e6e717efc8},
 created = {2015-02-26T19:47:58.000Z},
 file_attached = {false},
 profile_id = {624218fb-8957-3e79-afb5-27cca967200e},
 group_id = {ac791549-4a16-3252-8de1-0fdef1a59e25},
 last_modified = {2015-03-10T17:06:18.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bruno:2006aa},
 source_type = {article},
 folder_uuids = {886c64ff-fda7-4525-b6b0-c7319eef9f2d,db2540d2-49f3-4068-8c93-f82b72c33309},
 abstract = {Sensory stimuli reach the brain via the thalamocortical projection, a group of axons thought to be among the most powerful in the neocortex. Surprisingly, these axons account for only ∼15% of synapses onto cortical neurons. The thalamocortical pathway might thus achieve its effectiveness via high-efficacy thalamocortical synapses or via amplification within cortical layer 4. In rat somatosensory cortex, we measured in vivo the excitatory postsynaptic potential evoked by a single synaptic connection and found that thalamocortical synapses have low efficacy. Convergent inputs, however, are both numerous and synchronous, and intracortical amplification is not required. Our results suggest a mechanism of cortical activation by which thalamic input alone can drive cortex.},
 bibtype = {article},
 author = {Bruno, Randy M and Sakmann, Bert},
 journal = {Science},
 number = {5780}
}

{"_id":"mERLHPY82Kx2Ndxrf","bibbaseid":"bruno-sakmann-cortexisdrivenbyweakbutsynchronouslyactivethalamocorticalsynapses-2006","downloads":0,"creationDate":"2017-01-19T16:34:22.179Z","title":"Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses","author_short":["Bruno, R., M.","Sakmann, B."],"year":2006,"bibtype":"article","biburl":null,"bibdata":{"title":"Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses","type":"article","year":"2006","identifiers":"[object Object]","pages":"1622-1627","volume":"312","websites":"http://www.sciencemag.org/content/312/5780/1622.abstract","id":"50f175a6-a1f8-3349-93dc-01e6e717efc8","created":"2015-02-26T19:47:58.000Z","file_attached":false,"profile_id":"624218fb-8957-3e79-afb5-27cca967200e","group_id":"ac791549-4a16-3252-8de1-0fdef1a59e25","last_modified":"2015-03-10T17:06:18.000Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"citation_key":"Bruno:2006aa","source_type":"article","folder_uuids":"886c64ff-fda7-4525-b6b0-c7319eef9f2d,db2540d2-49f3-4068-8c93-f82b72c33309","abstract":"Sensory stimuli reach the brain via the thalamocortical projection, a group of axons thought to be among the most powerful in the neocortex. Surprisingly, these axons account for only ∼15% of synapses onto cortical neurons. The thalamocortical pathway might thus achieve its effectiveness via high-efficacy thalamocortical synapses or via amplification within cortical layer 4. In rat somatosensory cortex, we measured in vivo the excitatory postsynaptic potential evoked by a single synaptic connection and found that thalamocortical synapses have low efficacy. Convergent inputs, however, are both numerous and synchronous, and intracortical amplification is not required. Our results suggest a mechanism of cortical activation by which thalamic input alone can drive cortex.","bibtype":"article","author":"Bruno, Randy M and Sakmann, Bert","journal":"Science","number":"5780","bibtex":"@article{\n title = {Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses},\n type = {article},\n year = {2006},\n identifiers = {[object Object]},\n pages = {1622-1627},\n volume = {312},\n websites = {http://www.sciencemag.org/content/312/5780/1622.abstract},\n id = {50f175a6-a1f8-3349-93dc-01e6e717efc8},\n created = {2015-02-26T19:47:58.000Z},\n file_attached = {false},\n profile_id = {624218fb-8957-3e79-afb5-27cca967200e},\n group_id = {ac791549-4a16-3252-8de1-0fdef1a59e25},\n last_modified = {2015-03-10T17:06:18.000Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Bruno:2006aa},\n source_type = {article},\n folder_uuids = {886c64ff-fda7-4525-b6b0-c7319eef9f2d,db2540d2-49f3-4068-8c93-f82b72c33309},\n abstract = {Sensory stimuli reach the brain via the thalamocortical projection, a group of axons thought to be among the most powerful in the neocortex. Surprisingly, these axons account for only ∼15% of synapses onto cortical neurons. The thalamocortical pathway might thus achieve its effectiveness via high-efficacy thalamocortical synapses or via amplification within cortical layer 4. In rat somatosensory cortex, we measured in vivo the excitatory postsynaptic potential evoked by a single synaptic connection and found that thalamocortical synapses have low efficacy. Convergent inputs, however, are both numerous and synchronous, and intracortical amplification is not required. Our results suggest a mechanism of cortical activation by which thalamic input alone can drive cortex.},\n bibtype = {article},\n author = {Bruno, Randy M and Sakmann, Bert},\n journal = {Science},\n number = {5780}\n}","author_short":["Bruno, R., M.","Sakmann, B."],"urls":{"Website":"http://www.sciencemag.org/content/312/5780/1622.abstract"},"bibbaseid":"bruno-sakmann-cortexisdrivenbyweakbutsynchronouslyactivethalamocorticalsynapses-2006","role":"author","downloads":0},"search_terms":["cortex","driven","weak","synchronously","active","thalamocortical","synapses","bruno","sakmann"],"keywords":[],"authorIDs":[]}