@article{ Buia_Tiesinga06,
  author = {Buia, C. and Tiesinga, P.},
  title = {{{A}ttentional modulation of firing rate and synchrony in a model
	cortical network}},
  journal = {J Comput Neurosci},
  year = {2006},
  volume = {20},
  pages = {247--264},
  month = {Jun},
  abstract = {The response of a neuron in the visual cortex to stimuli of different
	contrast placed in its receptive field is commonly characterized
	using the contrast response curve. When attention is directed into
	the receptive field of a V4 neuron, its contrast response curve is
	shifted to lower contrast values (Reynolds et al., 2000). The neuron
	will thus be able to respond to weaker stimuli than it responded
	to without attention. Attention also increases the coherence between
	neurons responding to the same stimulus (Fries et al., 2001). We
	studied how the firing rate and synchrony of a densely interconnected
	cortical network varied with contrast and how they were modulated
	by attention. The changes in contrast and attention were modeled
	as changes in driving current to the network neurons.We found that
	an increased driving current to the excitatory neurons increased
	the overall firing rate of the network, whereas variation of the
	driving current to inhibitory neurons modulated the synchrony of
	the network. We explain the synchrony modulation in terms of a locking
	phenomenon during which the ratio of excitatory to inhibitory firing
	rates is approximately constant for a range of driving current values.We
	explored the hypothesis that contrast is represented primarily as
	a drive to the excitatory neurons, whereas attention corresponds
	to a reduction in driving current to the inhibitory neurons. Using
	this hypothesis, the model reproduces the following experimental
	observations: (1) the firing rate of the excitatory neurons increases
	with contrast; (2) for high contrast stimuli, the firing rate saturates
	and the network synchronizes; (3) attention shifts the contrast response
	curve to lower contrast values; (4) attention leads to stronger synchronization
	that starts at a lower value of the contrast compared with the attend-away
	condition. In addition, it predicts that attention increases the
	delay between the inhibitory and excitatory synchronous volleys produced
	by the network, allowing the stimulus to recruit more downstream
	neurons.}
}

{"_id":"kWuTcMtDmCzjRzEBY","bibbaseid":"buia-tiesinga-attentionalmodulationoffiringrateandsynchronyinamodelcorticalnetwork-2006","downloads":0,"creationDate":"2015-02-08T05:14:39.919Z","title":"Attentional modulation of firing rate and synchrony in a model cortical network","author_short":["Buia, C.","Tiesinga, P."],"year":2006,"bibtype":"article","biburl":"http://cnslab.mb.jhu.edu/niebase.bib","bibdata":{"abstract":"The response of a neuron in the visual cortex to stimuli of different contrast placed in its receptive field is commonly characterized using the contrast response curve. When attention is directed into the receptive field of a V4 neuron, its contrast response curve is shifted to lower contrast values (Reynolds et al., 2000). The neuron will thus be able to respond to weaker stimuli than it responded to without attention. Attention also increases the coherence between neurons responding to the same stimulus (Fries et al., 2001). We studied how the firing rate and synchrony of a densely interconnected cortical network varied with contrast and how they were modulated by attention. The changes in contrast and attention were modeled as changes in driving current to the network neurons.We found that an increased driving current to the excitatory neurons increased the overall firing rate of the network, whereas variation of the driving current to inhibitory neurons modulated the synchrony of the network. We explain the synchrony modulation in terms of a locking phenomenon during which the ratio of excitatory to inhibitory firing rates is approximately constant for a range of driving current values.We explored the hypothesis that contrast is represented primarily as a drive to the excitatory neurons, whereas attention corresponds to a reduction in driving current to the inhibitory neurons. Using this hypothesis, the model reproduces the following experimental observations: (1) the firing rate of the excitatory neurons increases with contrast; (2) for high contrast stimuli, the firing rate saturates and the network synchronizes; (3) attention shifts the contrast response curve to lower contrast values; (4) attention leads to stronger synchronization that starts at a lower value of the contrast compared with the attend-away condition. In addition, it predicts that attention increases the delay between the inhibitory and excitatory synchronous volleys produced by the network, allowing the stimulus to recruit more downstream neurons.","author":["Buia, C.","Tiesinga, P."],"author_short":["Buia, C.","Tiesinga, P."],"bibtex":"@article{ Buia_Tiesinga06,\n author = {Buia, C. and Tiesinga, P.},\n title = {{{A}ttentional modulation of firing rate and synchrony in a model\n\tcortical network}},\n journal = {J Comput Neurosci},\n year = {2006},\n volume = {20},\n pages = {247--264},\n month = {Jun},\n abstract = {The response of a neuron in the visual cortex to stimuli of different\n\tcontrast placed in its receptive field is commonly characterized\n\tusing the contrast response curve. When attention is directed into\n\tthe receptive field of a V4 neuron, its contrast response curve is\n\tshifted to lower contrast values (Reynolds et al., 2000). The neuron\n\twill thus be able to respond to weaker stimuli than it responded\n\tto without attention. Attention also increases the coherence between\n\tneurons responding to the same stimulus (Fries et al., 2001). We\n\tstudied how the firing rate and synchrony of a densely interconnected\n\tcortical network varied with contrast and how they were modulated\n\tby attention. The changes in contrast and attention were modeled\n\tas changes in driving current to the network neurons.We found that\n\tan increased driving current to the excitatory neurons increased\n\tthe overall firing rate of the network, whereas variation of the\n\tdriving current to inhibitory neurons modulated the synchrony of\n\tthe network. We explain the synchrony modulation in terms of a locking\n\tphenomenon during which the ratio of excitatory to inhibitory firing\n\trates is approximately constant for a range of driving current values.We\n\texplored the hypothesis that contrast is represented primarily as\n\ta drive to the excitatory neurons, whereas attention corresponds\n\tto a reduction in driving current to the inhibitory neurons. Using\n\tthis hypothesis, the model reproduces the following experimental\n\tobservations: (1) the firing rate of the excitatory neurons increases\n\twith contrast; (2) for high contrast stimuli, the firing rate saturates\n\tand the network synchronizes; (3) attention shifts the contrast response\n\tcurve to lower contrast values; (4) attention leads to stronger synchronization\n\tthat starts at a lower value of the contrast compared with the attend-away\n\tcondition. In addition, it predicts that attention increases the\n\tdelay between the inhibitory and excitatory synchronous volleys produced\n\tby the network, allowing the stimulus to recruit more downstream\n\tneurons.}\n}","bibtype":"article","id":"Buia_Tiesinga06","journal":"J Comput Neurosci","key":"Buia_Tiesinga06","month":"Jun","pages":"247--264","title":"Attentional modulation of firing rate and synchrony in a model cortical network","type":"article","volume":"20","year":"2006","bibbaseid":"buia-tiesinga-attentionalmodulationoffiringrateandsynchronyinamodelcorticalnetwork-2006","role":"author","urls":{},"downloads":0},"search_terms":["attentional","modulation","firing","rate","synchrony","model","cortical","network","buia","tiesinga"],"keywords":[],"authorIDs":[],"dataSources":["ErLXoH8mqSjESnrN5"]}