@ARTICLE{Bultje2009-tx,
  title    = "Mammalian Par3 regulates progenitor cell asymmetric division via
              notch signaling in the developing neocortex",
  author   = "Bultje, Ronald S and Castaneda-Castellanos, David R and Jan, Lily
              Yeh and Jan, Yuh-Nung and Kriegstein, Arnold R and Shi, Song-Hai",
  abstract = "Asymmetric cell division of radial glial progenitors produces
              neurons while allowing self-renewal; however, little is known
              about the mechanism that generates asymmetry in daughter cell
              fate specification. Here, we found that mammalian partition
              defective protein 3 (mPar3), a key cell polarity determinant,
              exhibits dynamic distribution in radial glial progenitors. While
              it is enriched at the lateral membrane domain in the ventricular
              endfeet during interphase, mPar3 becomes dispersed and shows
              asymmetric localization as cell cycle progresses. Either removal
              or ectopic expression of mPar3 prevents radial glial progenitors
              from dividing asymmetrically yet generates different outcomes in
              daughter cell fate specification. Furthermore, the expression
              level of mPar3 affects Notch signaling, and manipulations of
              Notch signaling or Numb expression suppress mPar3 regulation of
              radial glial cell division and daughter cell fate specification.
              These results reveal a critical molecular pathway underlying
              asymmetric cell division of radial glial progenitors in the
              mammalian neocortex.",
  journal  = "Neuron",
  volume   =  63,
  number   =  2,
  pages    = "189--202",
  month    =  jul,
  year     =  2009,
  language = "en"
}

{"_id":"aMGCZbrBaCT5HuWpz","bibbaseid":"bultje-castanedacastellanos-jan-jan-kriegstein-shi-mammalianpar3regulatesprogenitorcellasymmetricdivisionvianotchsignalinginthedevelopingneocortex-2009","author_short":["Bultje, R. S","Castaneda-Castellanos, D. R","Jan, L. Y.","Jan, Y.","Kriegstein, A. R","Shi, S."],"bibdata":{"bibtype":"article","type":"article","title":"Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex","author":[{"propositions":[],"lastnames":["Bultje"],"firstnames":["Ronald","S"],"suffixes":[]},{"propositions":[],"lastnames":["Castaneda-Castellanos"],"firstnames":["David","R"],"suffixes":[]},{"propositions":[],"lastnames":["Jan"],"firstnames":["Lily","Yeh"],"suffixes":[]},{"propositions":[],"lastnames":["Jan"],"firstnames":["Yuh-Nung"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Shi"],"firstnames":["Song-Hai"],"suffixes":[]}],"abstract":"Asymmetric cell division of radial glial progenitors produces neurons while allowing self-renewal; however, little is known about the mechanism that generates asymmetry in daughter cell fate specification. Here, we found that mammalian partition defective protein 3 (mPar3), a key cell polarity determinant, exhibits dynamic distribution in radial glial progenitors. While it is enriched at the lateral membrane domain in the ventricular endfeet during interphase, mPar3 becomes dispersed and shows asymmetric localization as cell cycle progresses. Either removal or ectopic expression of mPar3 prevents radial glial progenitors from dividing asymmetrically yet generates different outcomes in daughter cell fate specification. Furthermore, the expression level of mPar3 affects Notch signaling, and manipulations of Notch signaling or Numb expression suppress mPar3 regulation of radial glial cell division and daughter cell fate specification. These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex.","journal":"Neuron","volume":"63","number":"2","pages":"189–202","month":"July","year":"2009","language":"en","bibtex":"@ARTICLE{Bultje2009-tx,\n title = \"Mammalian Par3 regulates progenitor cell asymmetric division via\n notch signaling in the developing neocortex\",\n author = \"Bultje, Ronald S and Castaneda-Castellanos, David R and Jan, Lily\n Yeh and Jan, Yuh-Nung and Kriegstein, Arnold R and Shi, Song-Hai\",\n abstract = \"Asymmetric cell division of radial glial progenitors produces\n neurons while allowing self-renewal; however, little is known\n about the mechanism that generates asymmetry in daughter cell\n fate specification. Here, we found that mammalian partition\n defective protein 3 (mPar3), a key cell polarity determinant,\n exhibits dynamic distribution in radial glial progenitors. While\n it is enriched at the lateral membrane domain in the ventricular\n endfeet during interphase, mPar3 becomes dispersed and shows\n asymmetric localization as cell cycle progresses. Either removal\n or ectopic expression of mPar3 prevents radial glial progenitors\n from dividing asymmetrically yet generates different outcomes in\n daughter cell fate specification. Furthermore, the expression\n level of mPar3 affects Notch signaling, and manipulations of\n Notch signaling or Numb expression suppress mPar3 regulation of\n radial glial cell division and daughter cell fate specification.\n These results reveal a critical molecular pathway underlying\n asymmetric cell division of radial glial progenitors in the\n mammalian neocortex.\",\n journal = \"Neuron\",\n volume = 63,\n number = 2,\n pages = \"189--202\",\n month = jul,\n year = 2009,\n language = \"en\"\n}\n\n","author_short":["Bultje, R. S","Castaneda-Castellanos, D. R","Jan, L. Y.","Jan, Y.","Kriegstein, A. R","Shi, S."],"key":"Bultje2009-tx","id":"Bultje2009-tx","bibbaseid":"bultje-castanedacastellanos-jan-jan-kriegstein-shi-mammalianpar3regulatesprogenitorcellasymmetricdivisionvianotchsignalinginthedevelopingneocortex-2009","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["mammalian","par3","regulates","progenitor","cell","asymmetric","division","via","notch","signaling","developing","neocortex","bultje","castaneda-castellanos","jan","jan","kriegstein","shi"],"title":"Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex","year":2009}