Exosomes Transfer p53 between Cells and Can Suppress Growth and Proliferation of p53-Negative Cells. Burdakov, V., Kovalev, R., Pantina, R., Varfolomeeva, E., Makarov, E., & Filatov, M. Cell and Tissue Biology, 12(1):20-26, Maik Nauka-Interperiodica Publishing, 2018. cited By 2![Exosomes Transfer p53 between Cells and Can Suppress Growth and Proliferation of p53-Negative Cells [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Exosomes are nanosized vesicles that are secreted by many types of cells. We have found that exosomes secreted by HEK293 and HT-1080 can suppress growth and proliferation of p53-deficient cells. Upon overexpression of exogenous p53-GFP in HEK293 cells, we observed p53 protein in exosomes that were secreted by these cells. We also found endogenous p53 in exosomes that were secreted by HT-1080 cells with a higher level of p53 expression. We were able to detect endogenous p53 protein in exosomes that originated from human plasma and were transferred to p53-deficient cells. Our findings indicate that p53 protein can be transferred between cells and may play an important physiological role. © 2018, Pleiades Publishing, Ltd.
@ARTICLE{Burdakov201820,
author={Burdakov, V.S. and Kovalev, R.A. and Pantina, R.A. and Varfolomeeva, E.Y. and Makarov, E.M. and Filatov, M.V.},
title={Exosomes Transfer p53 between Cells and Can Suppress Growth and Proliferation of p53-Negative Cells},
journal={Cell and Tissue Biology},
year={2018},
volume={12},
number={1},
pages={20-26},
doi={10.1134/S1990519X18010030},
note={cited By 2},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042464427&doi=10.1134%2fS1990519X18010030&partnerID=40&md5=f9de8e8533842e75b6479cbae6afc729},
affiliation={Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Centre “Kurchatov Institute”, Gatchina, Leningrad oblast, 188300, Russian Federation; Department of Biophysics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, 194064, Russian Federation; College of Health and Life Sciences, Brunel University, London, Uxbridge, United Kingdom; St. Petersburg Institute of Phthisiopulmonology, St. Petersburg, 191036, Russian Federation},
abstract={Exosomes are nanosized vesicles that are secreted by many types of cells. We have found that exosomes secreted by HEK293 and HT-1080 can suppress growth and proliferation of p53-deficient cells. Upon overexpression of exogenous p53-GFP in HEK293 cells, we observed p53 protein in exosomes that were secreted by these cells. We also found endogenous p53 in exosomes that were secreted by HT-1080 cells with a higher level of p53 expression. We were able to detect endogenous p53 protein in exosomes that originated from human plasma and were transferred to p53-deficient cells. Our findings indicate that p53 protein can be transferred between cells and may play an important physiological role. © 2018, Pleiades Publishing, Ltd.},
author_keywords={cell lines; exosomes; р53},
correspondence_address1={Filatov, M.V.; Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Centre “Kurchatov Institute”Russian Federation; email: fil_53@mail.ru},
publisher={Maik Nauka-Interperiodica Publishing},
issn={1990519X},
language={English},
abbrev_source_title={Cell Tissue Biol.},
document_type={Article},
source={Scopus},
}
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