Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Burgard, A. P, Pharkya, P., & Maranas, C. D Biotechnology and bioengineering, 84(6):647–657, Wiley Online Library, 2003.
bibtex   
@article{burgard2003optknock,
  title={Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization},
  author={Burgard, Anthony P and Pharkya, Priti and Maranas, Costas D},
  journal={Biotechnology and bioengineering},
  volume={84},
  number={6},
  pages={647--657},
  year={2003},
  publisher={Wiley Online Library}
}

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