{"_id":"DCzAJEpjqr45yeFMW","bibbaseid":"burgoyne-patel-eden-calciumsignalingatermembranecontactsites-2015","authorIDs":["Gey9oRHLtcLaE43Di","Rm8AoJCrsyoSAqbJK","raAJz4GZgRogkJRLA","wrBGYyeRcAYsk9Gqp"],"author_short":["Burgoyne, T.","Patel, S.","Eden, E. R."],"bibdata":{"bibtype":"article","type":"article","title":"Calcium signaling at ER membrane contact sites","volume":"1853","issn":"0006-3002","doi":"10.1016/j.bbamcr.2015.01.022","abstract":"Communication between organelles is a necessary consequence of intracellular compartmentalization. Membrane contact sites (MCSs) are regions where the membranes of two organelles come into close apposition allowing exchange of small molecules and ions including Ca²⁺. The ER, the cell's major Ca²⁺ store, forms an extensive and dynamic network of contacts with multiple organelles. Here we review established and emerging roles of ER contacts as platforms for Ca²⁺ exchange and further consider a potential role for Ca²⁺ in the regulation of MCS formation. We additionally discuss the challenges associated with the study of MCS biology and highlight advances in microscopy-based solutions. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.","language":"eng","number":"9","journal":"Biochimica Et Biophysica Acta","author":[{"propositions":[],"lastnames":["Burgoyne"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Sandip"],"suffixes":[]},{"propositions":[],"lastnames":["Eden"],"firstnames":["Emily","R."],"suffixes":[]}],"month":"September","year":"2015","pmid":"25662816","keywords":"Animals, Ca2+ exchange, Calcium, Calcium Signaling, ER, Endoplasmic Reticulum, Humans, Intracellular Membranes, Membrane contact sites (MCSs)","pages":"2012–2017","bibtex":"@article{burgoyne_calcium_2015,\n\ttitle = {Calcium signaling at {ER} membrane contact sites},\n\tvolume = {1853},\n\tissn = {0006-3002},\n\tdoi = {10.1016/j.bbamcr.2015.01.022},\n\tabstract = {Communication between organelles is a necessary consequence of intracellular compartmentalization. Membrane contact sites (MCSs) are regions where the membranes of two organelles come into close apposition allowing exchange of small molecules and ions including Ca²⁺. The ER, the cell's major Ca²⁺ store, forms an extensive and dynamic network of contacts with multiple organelles. Here we review established and emerging roles of ER contacts as platforms for Ca²⁺ exchange and further consider a potential role for Ca²⁺ in the regulation of MCS formation. We additionally discuss the challenges associated with the study of MCS biology and highlight advances in microscopy-based solutions. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Biochimica Et Biophysica Acta},\n\tauthor = {Burgoyne, Thomas and Patel, Sandip and Eden, Emily R.},\n\tmonth = sep,\n\tyear = {2015},\n\tpmid = {25662816},\n\tkeywords = {Animals, Ca2+ exchange, Calcium, Calcium Signaling, ER, Endoplasmic Reticulum, Humans, Intracellular Membranes, Membrane contact sites (MCSs)},\n\tpages = {2012--2017}\n}\n\n","author_short":["Burgoyne, T.","Patel, S.","Eden, E. R."],"key":"burgoyne_calcium_2015","id":"burgoyne_calcium_2015","bibbaseid":"burgoyne-patel-eden-calciumsignalingatermembranecontactsites-2015","role":"author","urls":{},"keyword":["Animals","Ca2+ exchange","Calcium","Calcium Signaling","ER","Endoplasmic Reticulum","Humans","Intracellular Membranes","Membrane contact sites (MCSs)"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/3194591/collections/KWI4VFRQ/items?key=MIxmcGdU3NyPX8sp3hKDuJKx&format=bibtex&limit=100","creationDate":"2020-07-21T21:46:27.393Z","downloads":0,"keywords":["animals","ca2+ exchange","calcium","calcium signaling","er","endoplasmic reticulum","humans","intracellular membranes","membrane contact sites (mcss)"],"search_terms":["calcium","signaling","membrane","contact","sites","burgoyne","patel","eden"],"title":"Calcium signaling at ER membrane contact sites","year":2015,"dataSources":["Xw3EWd4x4rWTkCjFo"]}