Towards a needle-free diagnosis of malaria: in vivo identification and classification of red and white blood cells containing haemozoin. Burnett, J. L., Carns, J. L., & Richards-Kortum, R. Malaria Journal, 16:447, November, 2017.
Paper doi abstract bibtex Optical detection of circulating haemozoin has been suggested as a needle free method to diagnose malaria using in vivo microscopy. Haemozoin is generated within infected red blood cells by the malaria parasite, serving as a highly specific, endogenous biomarker of malaria. However, phagocytosis of haemozoin by white blood cells which persist after the infection is resolved presents the potential for false positive diagnosis; therefore, the focus of this work is to identify a feature of the haemozoin signal to discriminate between infected red blood cells and haemozoin-containing white blood cells.
@article{burnett_towards_2017,
title = {Towards a needle-free diagnosis of malaria: in vivo identification and classification of red and white blood cells containing haemozoin},
volume = {16},
issn = {1475-2875},
shorttitle = {Towards a needle-free diagnosis of malaria},
url = {https://doi.org/10.1186/s12936-017-2096-1},
doi = {10.1186/s12936-017-2096-1},
abstract = {Optical detection of circulating haemozoin has been suggested as a needle free method to diagnose malaria using in vivo microscopy. Haemozoin is generated within infected red blood cells by the malaria parasite, serving as a highly specific, endogenous biomarker of malaria. However, phagocytosis of haemozoin by white blood cells which persist after the infection is resolved presents the potential for false positive diagnosis; therefore, the focus of this work is to identify a feature of the haemozoin signal to discriminate between infected red blood cells and haemozoin-containing white blood cells.},
urldate = {2017-11-14},
journal = {Malaria Journal},
author = {Burnett, Jennifer L. and Carns, Jennifer L. and Richards-Kortum, Rebecca},
month = nov,
year = {2017},
keywords = {Haemozoin, In vivo, Malaria diagnostics, Microscopy, Pigment-containing white blood cells},
pages = {447}
}
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