@article{
 title = {The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD<inf>3</inf>},
 type = {article},
 year = {2017},
 identifiers = {[object Object]},
 keywords = {Blood,Gene expression,MiRNA expression,Solar ultraviolet radiation,Vitamin D},
 volume = {159},
 id = {3b58885d-ccc2-3637-b23a-8c8223229bc0},
 created = {2017-08-29T11:47:33.447Z},
 file_attached = {false},
 profile_id = {21752b84-a4bb-338b-9831-50cd218d6851},
 last_modified = {2017-08-29T11:47:33.447Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {© 2017 Elsevier Inc. The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D 3  [25OHD 3 ] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 25OHD 3  levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 25OHD 3  and blood cell subpopulations.},
 bibtype = {article},
 author = {Bustamante, M. and Hernandez-Ferrer, C. and Sarria, Y. and Harrison, G.I. and Nonell, L. and Kang, W. and Friedländer, M.R. and Estivill, X. and González, J.R. and Nieuwenhuijsen, M. and Young, A.R.},
 journal = {Environmental Research}
}

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The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D 3 [25OHD 3 ] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 25OHD 3 levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 25OHD 3 and blood cell subpopulations.","bibtype":"article","author":"Bustamante, M. and Hernandez-Ferrer, C. and Sarria, Y. and Harrison, G.I. and Nonell, L. and Kang, W. and Friedländer, M.R. and Estivill, X. and González, J.R. and Nieuwenhuijsen, M. and Young, A.R.","journal":"Environmental Research","bibtex":"@article{\n title = {The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD<inf>3</inf>},\n type = {article},\n year = {2017},\n identifiers = {[object Object]},\n keywords = {Blood,Gene expression,MiRNA expression,Solar ultraviolet radiation,Vitamin D},\n volume = {159},\n id = {3b58885d-ccc2-3637-b23a-8c8223229bc0},\n created = {2017-08-29T11:47:33.447Z},\n file_attached = {false},\n profile_id = {21752b84-a4bb-338b-9831-50cd218d6851},\n last_modified = {2017-08-29T11:47:33.447Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {© 2017 Elsevier Inc. The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D 3 [25OHD 3 ] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 25OHD 3 levels. 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