@article{
 title = {Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {*Exercise,Choline/*blood,Female,Humans,Male,Oxygen Consumption,Reference Values},
 pages = {e42330},
 volume = {7},
 edition = {2012/08/04},
 id = {22d7fea2-45d3-33a2-bd5b-1497aaea350f},
 created = {2020-04-08T11:14:58.018Z},
 file_attached = {false},
 profile_id = {35256b02-5c01-377d-987f-c976bbd9b2b3},
 last_modified = {2020-04-08T11:17:05.394Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {1932-6203
Bye, Anja
Vettukattil, Riyas
Aspenes, Stian T
Giskeodegard, Guro F
Gribbestad, Ingrid S
Wisloff, Ulrik
Bathen, Tone F
Journal Article
Research Support, Non-U.S. Gov't
United States
PLoS One. 2012;7(7):e42330. doi: 10.1371/journal.pone.0042330. Epub 2012 Jul 30.},
 private_publication = {false},
 abstract = {BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention strategies before the individuals are diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen uptake (VO(2max)), is the single best predictor of future CVD mortality in healthy people. Based on this, we wanted to study differences between healthy individuals with a large difference in VO(2max)-level to identify new biomarkers of low aerobic fitness that may also have potential as early biomarkers of CVD risk. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples from 218 healthy individuals with a low VO(2max) (n = 108, 63 women) or high VO(2max) (n = 110, 64 women) were analysed with MR metabolomics. In addition, standard clinical-chemical analyses for glucose, lipids, liver enzymes, micro-CRP, and colorimetric analysis on circulating choline were performed. Individuals in the low VO(2max)-group had increased serum levels of free choline, decreased phosphatidylcholine, increased glucose and decreased unsaturated fatty acids compared to the individuals in the high VO(2max)-group. CONCLUSIONS/SIGNIFICANCE: Aerobic fitness dependent differences in serum levels of free choline and phosphatidylcholine are observed. They should be further studied as potential early markers of CVD risk.},
 bibtype = {article},
 author = {Bye, A and Vettukattil, R and Aspenes, S T and Giskeodegard, G F and Gribbestad, I S and Wisloff, U and Bathen, T F},
 journal = {PLoS One},
 number = {7}
}

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Epub 2012 Jul 30.","private_publication":false,"abstract":"BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention strategies before the individuals are diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen uptake (VO(2max)), is the single best predictor of future CVD mortality in healthy people. Based on this, we wanted to study differences between healthy individuals with a large difference in VO(2max)-level to identify new biomarkers of low aerobic fitness that may also have potential as early biomarkers of CVD risk. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples from 218 healthy individuals with a low VO(2max) (n = 108, 63 women) or high VO(2max) (n = 110, 64 women) were analysed with MR metabolomics. In addition, standard clinical-chemical analyses for glucose, lipids, liver enzymes, micro-CRP, and colorimetric analysis on circulating choline were performed. Individuals in the low VO(2max)-group had increased serum levels of free choline, decreased phosphatidylcholine, increased glucose and decreased unsaturated fatty acids compared to the individuals in the high VO(2max)-group. CONCLUSIONS/SIGNIFICANCE: Aerobic fitness dependent differences in serum levels of free choline and phosphatidylcholine are observed. They should be further studied as potential early markers of CVD risk.","bibtype":"article","author":"Bye, A and Vettukattil, R and Aspenes, S T and Giskeodegard, G F and Gribbestad, I S and Wisloff, U and Bathen, T F","journal":"PLoS One","number":"7","bibtex":"@article{\n title = {Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study},\n type = {article},\n year = {2012},\n identifiers = {[object Object]},\n keywords = {*Exercise,Choline/*blood,Female,Humans,Male,Oxygen Consumption,Reference Values},\n pages = {e42330},\n volume = {7},\n edition = {2012/08/04},\n id = {22d7fea2-45d3-33a2-bd5b-1497aaea350f},\n created = {2020-04-08T11:14:58.018Z},\n file_attached = {false},\n profile_id = {35256b02-5c01-377d-987f-c976bbd9b2b3},\n last_modified = {2020-04-08T11:17:05.394Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n source_type = {Journal Article},\n language = {eng},\n notes = {1932-6203\rBye, Anja\rVettukattil, Riyas\rAspenes, Stian T\rGiskeodegard, Guro F\rGribbestad, Ingrid S\rWisloff, Ulrik\rBathen, Tone F\rJournal Article\rResearch Support, Non-U.S. Gov't\rUnited States\rPLoS One. 2012;7(7):e42330. doi: 10.1371/journal.pone.0042330. Epub 2012 Jul 30.},\n private_publication = {false},\n abstract = {BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention strategies before the individuals are diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen uptake (VO(2max)), is the single best predictor of future CVD mortality in healthy people. Based on this, we wanted to study differences between healthy individuals with a large difference in VO(2max)-level to identify new biomarkers of low aerobic fitness that may also have potential as early biomarkers of CVD risk. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples from 218 healthy individuals with a low VO(2max) (n = 108, 63 women) or high VO(2max) (n = 110, 64 women) were analysed with MR metabolomics. In addition, standard clinical-chemical analyses for glucose, lipids, liver enzymes, micro-CRP, and colorimetric analysis on circulating choline were performed. Individuals in the low VO(2max)-group had increased serum levels of free choline, decreased phosphatidylcholine, increased glucose and decreased unsaturated fatty acids compared to the individuals in the high VO(2max)-group. CONCLUSIONS/SIGNIFICANCE: Aerobic fitness dependent differences in serum levels of free choline and phosphatidylcholine are observed. They should be further studied as potential early markers of CVD risk.},\n bibtype = {article},\n author = {Bye, A and Vettukattil, R and Aspenes, S T and Giskeodegard, G F and Gribbestad, I S and Wisloff, U and Bathen, T F},\n journal = {PLoS One},\n number = {7}\n}","author_short":["Bye, A.","Vettukattil, R.","Aspenes, S., T.","Giskeodegard, G., F.","Gribbestad, I., S.","Wisloff, U.","Bathen, T., F."],"bibbaseid":"bye-vettukattil-aspenes-giskeodegard-gribbestad-wisloff-bathen-serumlevelsofcholinecontainingcompoundsareassociatedwithaerobicfitnesslevelthehuntstudy-2012","role":"author","urls":{},"keyword":["*Exercise","Choline/*blood","Female","Humans","Male","Oxygen Consumption","Reference Values"],"downloads":0,"html":""},"bibtype":"article","creationDate":"2020-04-08T11:17:22.355Z","downloads":0,"keywords":["*exercise","choline/*blood","female","humans","male","oxygen consumption","reference values"],"search_terms":["serum","levels","choline","containing","compounds","associated","aerobic","fitness","level","hunt","study","bye","vettukattil","aspenes","giskeodegard","gribbestad","wisloff","bathen"],"title":"Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study","year":2012}