@article{cachay_herpes_2007,
	title = {Herpes simplex virus type 2 infection does not influence viral dynamics during early {HIV}-1 infection},
	volume = {195},
	issn = {0022-1899},
	doi = {10.1086/513568},
	abstract = {OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California.
DESIGN: The study was a retrospective cohort analysis.
METHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry.
RESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5\%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection.
CONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.},
	language = {eng},
	number = {9},
	journal = {The Journal of Infectious Diseases},
	author = {Cachay, Edward R. and Frost, Simon D. W. and Richman, Douglas D. and Smith, Davey M. and Little, Susan J.},
	month = may,
	year = {2007},
	pmid = {17396995},
	keywords = {Adult, California, Cohort Studies, HIV Infections, HIV-1, Herpes Simplex, Herpesvirus 2, Human, Humans, Longitudinal Studies, Male, Prevalence, Retrospective Studies, Viral Load},
	pages = {1270--1277},
}

{"_id":"4MGCowioCiLGq32CY","bibbaseid":"cachay-frost-richman-smith-little-herpessimplexvirustype2infectiondoesnotinfluenceviraldynamicsduringearlyhiv1infection-2007","downloads":0,"creationDate":"2019-04-11T18:03:36.128Z","title":"Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection","author_short":["Cachay, E. R.","Frost, S. D. W.","Richman, D. D.","Smith, D. M.","Little, S. J."],"year":2007,"bibtype":"article","biburl":"https://bibbase.org/zotero/ucsdpirc","bibdata":{"bibtype":"article","type":"article","title":"Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection","volume":"195","issn":"0022-1899","doi":"10.1086/513568","abstract":"OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California. DESIGN: The study was a retrospective cohort analysis. METHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry. RESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection. CONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.","language":"eng","number":"9","journal":"The Journal of Infectious Diseases","author":[{"propositions":[],"lastnames":["Cachay"],"firstnames":["Edward","R."],"suffixes":[]},{"propositions":[],"lastnames":["Frost"],"firstnames":["Simon","D.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Richman"],"firstnames":["Douglas","D."],"suffixes":[]},{"propositions":[],"lastnames":["Smith"],"firstnames":["Davey","M."],"suffixes":[]},{"propositions":[],"lastnames":["Little"],"firstnames":["Susan","J."],"suffixes":[]}],"month":"May","year":"2007","pmid":"17396995","keywords":"Adult, California, Cohort Studies, HIV Infections, HIV-1, Herpes Simplex, Herpesvirus 2, Human, Humans, Longitudinal Studies, Male, Prevalence, Retrospective Studies, Viral Load","pages":"1270–1277","bibtex":"@article{cachay_herpes_2007,\n\ttitle = {Herpes simplex virus type 2 infection does not influence viral dynamics during early {HIV}-1 infection},\n\tvolume = {195},\n\tissn = {0022-1899},\n\tdoi = {10.1086/513568},\n\tabstract = {OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California.\nDESIGN: The study was a retrospective cohort analysis.\nMETHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry.\nRESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5\\%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection.\nCONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Cachay, Edward R. and Frost, Simon D. W. and Richman, Douglas D. and Smith, Davey M. and Little, Susan J.},\n\tmonth = may,\n\tyear = {2007},\n\tpmid = {17396995},\n\tkeywords = {Adult, California, Cohort Studies, HIV Infections, HIV-1, Herpes Simplex, Herpesvirus 2, Human, Humans, Longitudinal Studies, Male, Prevalence, Retrospective Studies, Viral Load},\n\tpages = {1270--1277},\n}\n\n","author_short":["Cachay, E. R.","Frost, S. D. W.","Richman, D. D.","Smith, D. M.","Little, S. J."],"key":"cachay_herpes_2007","id":"cachay_herpes_2007","bibbaseid":"cachay-frost-richman-smith-little-herpessimplexvirustype2infectiondoesnotinfluenceviraldynamicsduringearlyhiv1infection-2007","role":"author","urls":{},"keyword":["Adult","California","Cohort Studies","HIV Infections","HIV-1","Herpes Simplex","Herpesvirus 2","Human","Humans","Longitudinal Studies","Male","Prevalence","Retrospective Studies","Viral Load"],"metadata":{"authorlinks":{}}},"search_terms":["herpes","simplex","virus","type","infection","influence","viral","dynamics","during","early","hiv","infection","cachay","frost","richman","smith","little"],"keywords":["adult","california","cohort studies","hiv infections","hiv-1","herpes simplex","herpesvirus 2","human","humans","longitudinal studies","male","prevalence","retrospective studies","viral load"],"authorIDs":[],"dataSources":["q7QJpHKwWD5taSmia"]}