@article{cairnesPlantAnticancerAgents1980,
  title = {Plant {{Anticancer Agents}}. {{X}}. {{Lignans From Juniperus}} Phoenicea},
  author = {Cairnes, David A. and Ekundayo, Olusegun and Kingston, David G. I.},
  date = {1980-07},
  journaltitle = {Journal of Natural Products},
  volume = {43},
  pages = {495--497},
  issn = {1520-6025},
  doi = {10.1021/np50010a010},
  url = {http://mfkp.org/INRMM/article/13699777},
  abstract = {Desoxypodophyllotoxin and fhpeltatin-A methyl ether have been identified as the major cytotoxic components of Juniperus phoenicea. 

[Excerpt] Recent work on Juniperns phoenicea has revealed the presence of a variety of diterpenes and diterpene acids in this plant (1, 2), but no antileukemic or cytotoxic compounds have been reported from it, although the presence of desoxypodo-phyllotoxin in J. bermudiana (3) and J. siliciola (4) has been reported. In a continuation of our search for anticancer compounds of plant origin, we have examined etbanolie extracts of J. phoenicea for cytotoxic and antileukemic con-stituents. 

[] Extraction of twigs and leaves of J. phoenicea with ethanol yielded an extract which showed cytotoxicity in the KB cell culture system. This extract was subjected to repeated chromatography on silica gel to give an active fraction which consisted of a mixture of closely related compounds, inseparable by further normal phase chromatography. Separation was effected readily, however, by reverse phase high performance liquid chromatography (hplc) (5) and yielded two pure cytotoxic compounds. Compound 1 was identified as desoxypodophyllotoxin on the basis of its spectroscopic properties; the identification was confirmed by comparison with an authentic sample. Compound 2 was identified as i9-peltatin-A methyl ether on the basis of its spectroscopic properties and by comparison with an authentic sample (6). [...]},
  keywords = {*imported-from-citeulike-INRMM,~INRMM-MiD:c-13699777,~to-add-doi-URL,forest-resources,juniperus-phoenicea,medicinal-plants},
  number = {4}
}

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[Excerpt] Recent work on Juniperns phoenicea has revealed the presence of a variety of diterpenes and diterpene acids in this plant (1, 2), but no antileukemic or cytotoxic compounds have been reported from it, although the presence of desoxypodo-phyllotoxin in J. bermudiana (3) and J. siliciola (4) has been reported. In a continuation of our search for anticancer compounds of plant origin, we have examined etbanolie extracts of J. phoenicea for cytotoxic and antileukemic con-stituents. [] Extraction of twigs and leaves of J. phoenicea with ethanol yielded an extract which showed cytotoxicity in the KB cell culture system. This extract was subjected to repeated chromatography on silica gel to give an active fraction which consisted of a mixture of closely related compounds, inseparable by further normal phase chromatography. Separation was effected readily, however, by reverse phase high performance liquid chromatography (hplc) (5) and yielded two pure cytotoxic compounds. Compound 1 was identified as desoxypodophyllotoxin on the basis of its spectroscopic properties; the identification was confirmed by comparison with an authentic sample. Compound 2 was identified as i9-peltatin-A methyl ether on the basis of its spectroscopic properties and by comparison with an authentic sample (6). [...]","keywords":"*imported-from-citeulike-INRMM,~INRMM-MiD:c-13699777,~to-add-doi-URL,forest-resources,juniperus-phoenicea,medicinal-plants","number":"4","bibtex":"@article{cairnesPlantAnticancerAgents1980,\n title = {Plant {{Anticancer Agents}}. {{X}}. {{Lignans From Juniperus}} Phoenicea},\n author = {Cairnes, David A. and Ekundayo, Olusegun and Kingston, David G. I.},\n date = {1980-07},\n journaltitle = {Journal of Natural Products},\n volume = {43},\n pages = {495--497},\n issn = {1520-6025},\n doi = {10.1021/np50010a010},\n url = {http://mfkp.org/INRMM/article/13699777},\n abstract = {Desoxypodophyllotoxin and fhpeltatin-A methyl ether have been identified as the major cytotoxic components of Juniperus phoenicea. \n\n[Excerpt] Recent work on Juniperns phoenicea has revealed the presence of a variety of diterpenes and diterpene acids in this plant (1, 2), but no antileukemic or cytotoxic compounds have been reported from it, although the presence of desoxypodo-phyllotoxin in J. bermudiana (3) and J. siliciola (4) has been reported. In a continuation of our search for anticancer compounds of plant origin, we have examined etbanolie extracts of J. phoenicea for cytotoxic and antileukemic con-stituents. \n\n[] Extraction of twigs and leaves of J. phoenicea with ethanol yielded an extract which showed cytotoxicity in the KB cell culture system. This extract was subjected to repeated chromatography on silica gel to give an active fraction which consisted of a mixture of closely related compounds, inseparable by further normal phase chromatography. Separation was effected readily, however, by reverse phase high performance liquid chromatography (hplc) (5) and yielded two pure cytotoxic compounds. Compound 1 was identified as desoxypodophyllotoxin on the basis of its spectroscopic properties; the identification was confirmed by comparison with an authentic sample. Compound 2 was identified as i9-peltatin-A methyl ether on the basis of its spectroscopic properties and by comparison with an authentic sample (6). [...]},\n keywords = {*imported-from-citeulike-INRMM,~INRMM-MiD:c-13699777,~to-add-doi-URL,forest-resources,juniperus-phoenicea,medicinal-plants},\n number = {4}\n}\n\n","author_short":["Cairnes, D. A.","Ekundayo, O.","Kingston, D. G. 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