Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine. Cait, A., Mooney, A., Poyntz, H., Shortt, N., Jones, A., Gestin, A., Gell, K., Grooby, A., O’Sullivan, D., Tang, J. S., Young, W., Thayabaran, D., Sparks, J., Ostapowicz, T., Tay, A., Poppitt, S. D., Elliott, S., Wakefield, G., Parry-Strong, A., Ralston, J., Beasley, R., Weatherall, M., Braithwaite, I., Forbes-Blom, E., & Gasser, O. Frontiers in Immunology, 12:765528, November, 2021. ![Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated de novo vaccinations.
@article{cait_potential_2021,
title = {Potential {Association} {Between} {Dietary} {Fibre} and {Humoral} {Response} to the {Seasonal} {Influenza} {Vaccine}},
volume = {12},
issn = {1664-3224},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2021.765528/full},
doi = {10.3389/fimmu.2021.765528},
abstract = {Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated
de novo
vaccinations.},
urldate = {2022-03-27},
journal = {Frontiers in Immunology},
author = {Cait, Alissa and Mooney, Anna and Poyntz, Hazel and Shortt, Nick and Jones, Angela and Gestin, Aurélie and Gell, Katie and Grooby, Alix and O’Sullivan, David and Tang, Jeffry S. and Young, Wayne and Thayabaran, Darmiga and Sparks, Jenny and Ostapowicz, Tess and Tay, Audrey and Poppitt, Sally D. and Elliott, Sarah and Wakefield, Georgia and Parry-Strong, Amber and Ralston, Jacqui and Beasley, Richard and Weatherall, Mark and Braithwaite, Irene and Forbes-Blom, Elizabeth and Gasser, Olivier},
month = nov,
year = {2021},
pages = {765528},
}
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