Circadian desynchronization of core body temperature and sleep stages in the rat.

Circadian desynchronization of core body temperature and sleep stages in the rat. Cambras, T., Weller, J. R, Anglès-Pujoràs, M., Lee, M. L, Christopher, A., Díez-Noguera, A., Krueger, J. M, & de la Iglesia, H. O Proc Natl Acad Sci U S A, 104(18):7634-9, 2007.
doi abstract bibtex

Proper functioning of the human circadian timing system is crucial to physical and mental health. Much of what we know about this system is based on experimental protocols that induce the desynchronization of behavioral and physiological rhythms within individual subjects, but the neural (or extraneural) substrates for such desynchronization are unknown. We have developed an animal model of human internal desynchrony in which rats are exposed to artificially short (22-h) light-dark cycles. Under these conditions, locomotor activity, sleep-wake, and slow-wave sleep (SWS) exhibit two rhythms within individual animals, one entrained to the 22-h light-dark cycle and the other free-running with a period >24 h (tau(>24 h)). Whereas core body temperature showed two rhythms as well, further analysis indicates this variable oscillates more according to the tau(>24 h) rhythm than to the 22-h rhythm, and that this oscillation is due to an activity-independent circadian regulation. Paradoxical sleep (PS), on the other hand, shows only one free-running rhythm. Our results show that, similarly to humans, (i) circadian rhythms can be internally dissociated in a controlled and predictable manner in the rat and (ii) the circadian rhythms of sleep-wake and SWS can be desynchronized from the rhythms of PS and core body temperature within individual animals. This model now allows for a deeper understanding of the human timekeeping mechanism, for testing potential therapies for circadian dysrhythmias, and for studying the biology of PS and SWS states in a neurologically intact model.

@Article{Cambras2007,
  author   = {Trinitat Cambras and John R Weller and Montserrat Angl\`es-Pujor\`as and Michael L Lee and Andrea Christopher and Antoni D\'iez-Noguera and James M Krueger and Horacio O de la Iglesia},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Circadian desynchronization of core body temperature and sleep stages in the rat.},
  year     = {2007},
  number   = {18},
  pages    = {7634-9},
  volume   = {104},
  abstract = {Proper functioning of the human circadian timing system is crucial
	to physical and mental health. Much of what we know about this system
	is based on experimental protocols that induce the desynchronization
	of behavioral and physiological rhythms within individual subjects,
	but the neural (or extraneural) substrates for such desynchronization
	are unknown. We have developed an animal model of human internal
	desynchrony in which rats are exposed to artificially short (22-h)
	light-dark cycles. Under these conditions, locomotor activity, sleep-wake,
	and slow-wave sleep (SWS) exhibit two rhythms within individual animals,
	one entrained to the 22-h light-dark cycle and the other free-running
	with a period >24 h (tau(>24 h)). Whereas core body temperature showed
	two rhythms as well, further analysis indicates this variable oscillates
	more according to the tau(>24 h) rhythm than to the 22-h rhythm,
	and that this oscillation is due to an activity-independent circadian
	regulation. Paradoxical sleep (PS), on the other hand, shows only
	one free-running rhythm. Our results show that, similarly to humans,
	(i) circadian rhythms can be internally dissociated in a controlled
	and predictable manner in the rat and (ii) the circadian rhythms
	of sleep-wake and SWS can be desynchronized from the rhythms of PS
	and core body temperature within individual animals. This model now
	allows for a deeper understanding of the human timekeeping mechanism,
	for testing potential therapies for circadian dysrhythmias, and for
	studying the biology of PS and SWS states in a neurologically intact
	model.},
  doi      = {10.1073/pnas.0702424104},
  keywords = {Animals, Body Temperature, Circadian Rhythm, Male, Rats, Sleep Stages, Wistar, 17452631},
}

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Much of what we know about this system is based on experimental protocols that induce the desynchronization of behavioral and physiological rhythms within individual subjects, but the neural (or extraneural) substrates for such desynchronization are unknown. We have developed an animal model of human internal desynchrony in which rats are exposed to artificially short (22-h) light-dark cycles. Under these conditions, locomotor activity, sleep-wake, and slow-wave sleep (SWS) exhibit two rhythms within individual animals, one entrained to the 22-h light-dark cycle and the other free-running with a period >24 h (tau(>24 h)). Whereas core body temperature showed two rhythms as well, further analysis indicates this variable oscillates more according to the tau(>24 h) rhythm than to the 22-h rhythm, and that this oscillation is due to an activity-independent circadian regulation. Paradoxical sleep (PS), on the other hand, shows only one free-running rhythm. 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