Mitochondrial genetic effects on reproductive success: Signatures of positive intrasexual, but negative intersexual pleiotropy. Camus, M. & Dowling, D. Proceedings of the Royal Society B: Biological Sciences, 2018. abstract bibtex © 2018 The Author(s) Published by the Royal Society. All rights reserved. Theory predicts that maternal inheritance of mitochondria will facilitate the accumulation of mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there are many reported cases of mtDNA mutations conferring cytoplasmic male sterility in plants, historically it was assumed such mutations would not persist in the streamlined mitochondrial genomes of bilaterian metazoans. Intriguingly, recent cases of mitochondrial variants exerting male biases in effect have come to light in bilaterians. These cases aside, it remains unknown whether the mitochondrial genetic variation affecting phenotypic expression, and in particular reproductive performance, in bilaterians is routinely composed of sex-biased or sex-specific variation. If selection consistently favours mtDNA variants that augment female fitness, but at cost to males, this could shape patterns of pleiotropy and lead to negative intersexual correlations across mtDNA haplotypes. Here, we show that genetic variation across naturally occurring mitochondrial haplotypes affects components of reproductive success in both sexes, in the fruit fly Drosophila melanogaster. We find that intrasexual correlations across mitochondrial haplotypes, for components of reproductive success, are generally positive, while intersexual correlations are negative. These results accord with theoretical predictions, suggesting that maternal inheritance has led to the fixation of numerous mutations of sexually antagonistic effect.
@article{
title = {Mitochondrial genetic effects on reproductive success: Signatures of positive intrasexual, but negative intersexual pleiotropy},
type = {article},
year = {2018},
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keywords = {Life history,Maternal inheritance,Mitochondria,Reproduction,Sexual antagonism,Sexual conflict},
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abstract = {© 2018 The Author(s) Published by the Royal Society. All rights reserved. Theory predicts that maternal inheritance of mitochondria will facilitate the accumulation of mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there are many reported cases of mtDNA mutations conferring cytoplasmic male sterility in plants, historically it was assumed such mutations would not persist in the streamlined mitochondrial genomes of bilaterian metazoans. Intriguingly, recent cases of mitochondrial variants exerting male biases in effect have come to light in bilaterians. These cases aside, it remains unknown whether the mitochondrial genetic variation affecting phenotypic expression, and in particular reproductive performance, in bilaterians is routinely composed of sex-biased or sex-specific variation. If selection consistently favours mtDNA variants that augment female fitness, but at cost to males, this could shape patterns of pleiotropy and lead to negative intersexual correlations across mtDNA haplotypes. Here, we show that genetic variation across naturally occurring mitochondrial haplotypes affects components of reproductive success in both sexes, in the fruit fly Drosophila melanogaster. We find that intrasexual correlations across mitochondrial haplotypes, for components of reproductive success, are generally positive, while intersexual correlations are negative. These results accord with theoretical predictions, suggesting that maternal inheritance has led to the fixation of numerous mutations of sexually antagonistic effect.},
bibtype = {article},
author = {Camus, M.F. and Dowling, D.K.},
journal = {Proceedings of the Royal Society B: Biological Sciences},
number = {1879}
}
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Theory predicts that maternal inheritance of mitochondria will facilitate the accumulation of mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there are many reported cases of mtDNA mutations conferring cytoplasmic male sterility in plants, historically it was assumed such mutations would not persist in the streamlined mitochondrial genomes of bilaterian metazoans. Intriguingly, recent cases of mitochondrial variants exerting male biases in effect have come to light in bilaterians. These cases aside, it remains unknown whether the mitochondrial genetic variation affecting phenotypic expression, and in particular reproductive performance, in bilaterians is routinely composed of sex-biased or sex-specific variation. If selection consistently favours mtDNA variants that augment female fitness, but at cost to males, this could shape patterns of pleiotropy and lead to negative intersexual correlations across mtDNA haplotypes. Here, we show that genetic variation across naturally occurring mitochondrial haplotypes affects components of reproductive success in both sexes, in the fruit fly Drosophila melanogaster. We find that intrasexual correlations across mitochondrial haplotypes, for components of reproductive success, are generally positive, while intersexual correlations are negative. These results accord with theoretical predictions, suggesting that maternal inheritance has led to the fixation of numerous mutations of sexually antagonistic effect.","bibtype":"article","author":"Camus, M.F. and Dowling, D.K.","journal":"Proceedings of the Royal Society B: Biological Sciences","number":"1879","bibtex":"@article{\n title = {Mitochondrial genetic effects on reproductive success: Signatures of positive intrasexual, but negative intersexual pleiotropy},\n type = {article},\n year = {2018},\n identifiers = {[object Object]},\n keywords = {Life history,Maternal inheritance,Mitochondria,Reproduction,Sexual antagonism,Sexual conflict},\n volume = {285},\n id = {f2e23750-7ee1-3b42-ab58-e56d4860d55a},\n created = {2018-06-05T22:34:16.797Z},\n file_attached = {false},\n profile_id = {546abfaf-1ae6-3bfb-801c-e676c4427313},\n last_modified = {2018-06-05T22:34:16.797Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {© 2018 The Author(s) Published by the Royal Society. 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