Long-term prognosis in Crohn's disease: factors that affect quality of life. Canavan, C., Abrams, K. R., Hawthorne, B., Drossman, D., & Mayberry, J. F. Alimentary Pharmacology & Therapeutics, 23(3):377–385, February, 2006.
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BACKGROUND: There are many studies investigating quality of life in recently diagnosed patients and following surgery for Crohn's disease, but there are none investigating quality of life changes with disease duration. The response shift model suggests quality of life improves with time following diagnosis. AIM: To assess how well the model applies to patients with Crohn's disease. METHODS: The Cardiff Crohn's disease database contains data on all patients diagnosed there since 1934. Three hundred and ninety four patients diagnosed before 1 January 1985 were traced and the mortality status on 31 December 2004 established. Two hundred and eleven still living were sent quality of life questionnaires. Two hundred and eighty five questionnaires were sent to patients with varying disease duration attending out-patient clinics in Leicester. RESULTS: Eighty-nine valid replies were received from Cardiff, 63 from Leicester patients diagnosed over 20 years, 69 from Leicester patients diagnosed \textless10 years. There was no difference in quality of life between newly diagnosed and established patients. Of greatest concern was possible need for ostomy, uncertain nature of disease, and lack of energy. Stepwise regression showed that increased disease severity, older age and smoking adversely affect quality of life. DISCUSSION: Quality of life is equally poor in patients with established disease as in those newly diagnosed, and directly correlates with disease severity. The response shift model may not be applicable in Crohn's disease.
@article{canavan_long-term_2006,
	title = {Long-term prognosis in {Crohn}'s disease: factors that affect quality of life},
	volume = {23},
	issn = {0269-2813},
	shorttitle = {Long-term prognosis in {Crohn}'s disease},
	doi = {10.1111/j.1365-2036.2006.02753.x},
	abstract = {BACKGROUND: There are many studies investigating quality of life in recently diagnosed patients and following surgery for Crohn's disease, but there are none investigating quality of life changes with disease duration. The response shift model suggests quality of life improves with time following diagnosis.
AIM: To assess how well the model applies to patients with Crohn's disease.
METHODS: The Cardiff Crohn's disease database contains data on all patients diagnosed there since 1934. Three hundred and ninety four patients diagnosed before 1 January 1985 were traced and the mortality status on 31 December 2004 established. Two hundred and eleven still living were sent quality of life questionnaires. Two hundred and eighty five questionnaires were sent to patients with varying disease duration attending out-patient clinics in Leicester.
RESULTS: Eighty-nine valid replies were received from Cardiff, 63 from Leicester patients diagnosed over 20 years, 69 from Leicester patients diagnosed {\textless}10 years. There was no difference in quality of life between newly diagnosed and established patients. Of greatest concern was possible need for ostomy, uncertain nature of disease, and lack of energy. Stepwise regression showed that increased disease severity, older age and smoking adversely affect quality of life.
DISCUSSION: Quality of life is equally poor in patients with established disease as in those newly diagnosed, and directly correlates with disease severity. The response shift model may not be applicable in Crohn's disease.},
	language = {eng},
	number = {3},
	journal = {Alimentary Pharmacology \& Therapeutics},
	author = {Canavan, C. and Abrams, K. R. and Hawthorne, B. and Drossman, D. and Mayberry, J. F.},
	month = feb,
	year = {2006},
	pmid = {16422997},
	keywords = {Adult, Aged, Crohn Disease, England, Female, Health Status, Humans, Male, Middle Aged, Prognosis, Quality of Life, Wales},
	pages = {377--385}
}
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